Title of Paper:Water-soluble adsorbent beta-cyclodextrin-grafted polyethyleneimine for removing bilirubin from plasma

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Date of Publication:2012-10-01

Journal:TRANSFUSION AND APHERESIS SCIENCE

Included Journals:SCIE、PubMed、Scopus

Volume:47

Issue:2

Page Number:159-165

ISSN No.:1473-0502

Key Words:Bilirubin; beta-Cyclodextrin; Polyethyleneimine; Water-soluble adsorbent

Abstract:A water-soluble adsorbent was developed for removing bilirubin from the plasma of hyper-bilirubinemia patient. The adsorbent was synthesized by grafting beta-cyclodextrin (beta-CD) to branched polyethyleneimine (PEI) matrix. The resulting beta-CD-PEI polymer had an average molecular weight of 163.7 kD, and it contained 56.3 beta-CD functional groups. In beta-CD-PEI-spiked dialysis, 35.8% of plasma bilirubin was removed, which was higher than that removed by the same concentration of bovine serum albumin. beta-CD-PEI also removed aromatic amino acids and bile acids. The results indicated that beta-CD-PEI could be an effective adsorbent for blood purification application aiming at the removal of toxins. (C) 2012 Published by Elsevier Ltd.