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Indexed by:期刊论文
Date of Publication:2017-04-30
Journal:CHEMICAL COMMUNICATIONS
Included Journals:SCIE、PubMed
Volume:53
Issue:34
Page Number:4714-4717
ISSN No.:1359-7345
Abstract:An organocatalytic asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides and alpha,beta-ynones has been developed. This reaction afforded spiro[dihydropyrrole-2,3'-oxindole] products in high chemical yields with excellent stereoselectivities (up to 99% yields, 420 : 1 dr and > 99% ee). Notably, a series of important spiro[pyrrole-oxindole] derivatives were readily obtained via oxidation of the cycloadducts, thus extending the diversity of the products.
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