吴成伟

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研究员

博士生导师

硕士生导师

性别:男

毕业院校:清华大学

学位:博士

所在单位:力学与航空航天学院

学科:工程力学. 生物与纳米力学

办公地点:力学楼306

联系方式:0411-84706353 13332292398 cwwu@dlut.edu.cn

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Microneedle, bio-microneedle and bio-inspired microneedle: A review

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论文类型:期刊论文

第一作者:Ma, Guojun

通讯作者:Wu, CW (reprint author), Dalian Univ Technol, State Key Lab Struct Anal Ind Equipment, Dept Engn Mech, Int Ctr Computat Mech,Fac Vehicle Engn & Mech, Dalian 116024, Peoples R China.

合写作者:Wu, Chengwei

发表时间:2017-04-10

发表刊物:JOURNAL OF CONTROLLED RELEASE

收录刊物:SCIE、EI、PubMed、ESI高被引论文

卷号:251

页面范围:11-23

ISSN号:0168-3659

关键字:Microneedle; Bio-microneedle; Transdermal drug delivery; Insertion force

摘要:Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows themwith many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs. Secondly, researches on inserting behavior and mechanical performances of MNs are discussed. Thirdly, literatures on the drug delivery and the pain resulted from the insertion of MNs are overviewed. Finally, some bio-microneedles and bio-inspired MNs are introduced. (C) 2017 Elsevier B.V. All rights reserved.