Title of Paper:Nickel-catalyzed C-H direct amination of benzoxazoles with secondary amines

Hits:

Date of Publication:2012-05-14

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:SCIE、EI、PubMed、Scopus

Volume:10

Issue:18

Page Number:3715-3720

ISSN No.:1477-0520

Abstract:In this article, a facile, efficient and practical method for Ni-catalyzed direct C-H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)(2)center dot 4H(2)O as catalyst, TBHP as oxidant and acid as the additive. Avariety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.