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论文类型：期刊论文

发表时间：2012-07-01

发表刊物：JOURNAL OF BIOMEDICAL OPTICS

收录刊物：SCIE、PubMed

卷号：17

期号：7

页面范围：070501

ISSN号：1083-3668

关键字：optical coherence tomography; fluorescence; atherogenesis; double-clad fiber; annexin V

摘要：We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070501