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Indexed by:期刊论文

Date of Publication:2013-11-11

Journal:TETRAHEDRON

Included Journals:SCIE、Scopus

Volume:69

Issue:45

Page Number:9422-9427

ISSN No.:0040-4020

Key Words:ortho-Nitration; Aromatic amines; Bismuth nitrate; Regioselectivity; Synthetic methods

Abstract:An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions. (C) 2013 Elsevier Ltd. All rights reserved.