包永明

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:大连理工大学

学位:博士

所在单位:生物工程学院

学科:生物化工. 生物化学与分子生物学. 生物工程与技术

办公地点:大连理工大学生物工程楼323;盘锦校区D06 302室

联系方式:E-mail:biosci@dlut.edu.cn Tel:13332280036

电子邮箱:biosci@dlut.edu.cn

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Antioxidant enzyme levels in pathogenesis of oral squamous cell carcinoma (OSCC).

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论文类型:期刊论文

发表时间:2014-11-01

发表刊物:Drug research

收录刊物:Scopus、PubMed

卷号:64

期号:11

页面范围:629-32

ISSN号:2194-9387

摘要:Increased oxidative stress and altered anti-oxidant defense systems have been implicated in the pathogenesis of several diseases including cancer. Therefore, the aim of our study is to evaluate the antioxidant enzyme levels such as superoxide dismutase (SOD) and catalase in blood samples and tissues collected from oral squamous cell carcinoma patients and compared with healthy controls.The collected blood samples and tumor tissues from the diseased individuals and the normal controls are analyzed for malondialdehyde (MDA) and nitric oxide (NO), which is the indicator of oxidative and nitrosative stress respectively. The anti-oxidant enzymes SOD and catalase levels are measured by UV visible spectrophotometer. Subsequently, immuno-histostaining for antioxidant enzymes were performed in oral squamous cell carcinoma biopsies and sections were analyzed.The levels of MDA and NO were significantly elevated in the blood and tissue samples of OSCC patients. The antioxidant enzymes SOD and catalase were significantly reduced in OSCC tissues; while in erythrocytes catalase level is reduced whereas the SOD level is increased. Further, the reduced immuno-histostaining was observed for catalase and SOD in OSCC tissues when compared to normal oral epithelium.The enhanced levels of MDA and NO revealed that increased oxidative stress in conjunction with the reduced antioxidant defense mechanism in OSCC patients, might be involved in cancer progression. Our results suggest that detection of reactive oxygen species (ROS) and antioxidant enzymes levels might be a valuable marker in cancer prognosis and for improving therapeutic strategies in oral cancer.  © Georg Thieme Verlag KG Stuttgart · New York.