贾凌云

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教授

博士生导师

硕士生导师

主要任职:生物工程学院院长、党委副书记

性别:女

毕业院校:大连理工大学

学位:博士

所在单位:生物工程学院

学科:生物工程与技术. 生物化工

办公地点:知微楼519房间

电子邮箱:lyjia@dlut.edu.cn

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Functionalized Magnetic Fe3O4-beta-Cyclodextran Nanoparticles for Efficient Removal of Bilirubin

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论文类型:期刊论文

发表时间:2016-06-01

发表刊物:JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

收录刊物:SCIE、EI

卷号:16

期号:6

页面范围:5537-5545

ISSN号:1533-4880

关键字:Magnetic Nanoparticles; beta-Cyclodextran; Bilirubin; Adsorbent; Removal

摘要:Bilirubin (BR), as a lipophilic toxin, can binds and deposits in various tissues, especially the brain tissue, leading to hepatic coma and even death. Magnetic nanoparticles adsorbent modified by beta-cyclodextran (Fe3O4-beta-CD) was developed to remove the BR from the plasma. Fe3O4-beta-CD nanoparticles was prepared through Schiff base reaction between the polyethylenimine (PEI)modified Fe3O4 and aldehyde-functionalized beta-CD, and characterized by Fourier transform infrared (FTIR) spectra, X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and dynamic light scattering (DLS). Under optimized conditions, the Fe3O4-beta-CD adsorbent could adsorb 225.6 mg/g free BR in PBS and reach the adsorption equilibrium within 90 min mainly through hydrophobic interaction. Moreover, the adsorbent displayed better adsorption capability in a dialysis system for BSA-bound bilirubin, plasma bilirubin and total bile acid, and the removal rates of those were 66%, 31% and 41% respectively. Because of the advantages of fast separation and purification process, low preparation cost, good adsorption capability for plasma bilirubin, Fe3O4-beta-CD may become an economical and promising absorbent of BR for clinical applications.