Our research comprises of recognition and visualization of bioactive molecules or ions which are associated with serious diseases, and smart nano-biomaterials for the targeting delivery of gene and drug. At present, we are focusing on the recognition of bioactive molecules in mitochondria of cells, selective labeling of mitochondria, design of bio-degradable nano drug delivery system regulated by the microenvironments of tumor, such as low pH, high reductive activity in tumor cells, and nano-delivery system of gene or siRNA for cancer therapy, multiple functional nano co-delivery system for combined therapy of cancer. We have secured two funding from Natural Science Foundation of China. More than 50 research papers have been published, 10 invention patents have been authorized in our group