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博士生导师

硕士生导师

性别:男

毕业院校:大连理工大学

学位:博士

所在单位:化工学院

办公地点:大连理工大学西部校区E座421室

联系方式:手机:13998430917

电子邮箱:jubenzhi@dlut.edu.cn

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Thermo-responsive behavior of propynyl-containing hydroxyethyl starch

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论文类型:期刊论文

第一作者:Jong, Kwanghyok

通讯作者:Jong, K (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Liaoning, Peoples R China.; Jong, K (reprint author), KimChaek Univ Technol, Dept Applicat Chem, Kimchaek, North Korea.

合写作者:Ju, Benzhi

发表时间:2017-02-01

发表刊物:COLLOID AND POLYMER SCIENCE

收录刊物:SCIE、EI、Scopus

卷号:295

期号:2

页面范围:307-315

ISSN号:0303-402X

关键字:Hydroxyethyl starch; Propynylation; Thermo-responsive; Hydrophobic modification

摘要:Thermo-responsive polymers present great advantages in the targeted delivery and release of drugs. In this study, a novel type of thermo-responsive polymer called 2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES) was synthesized via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with 2- propynylglycidyl ether (PGE). Aqueous PyHES solutions with an appropriate degree of substitution (DS) of hydrophobic propynyl groups exhibited strong thermo-responsive properties as well as a cloud point temperature (Tcp) that could be tuned within a range of 31 to 48 A degrees C by changing the DS or PyHES concentrations. Moreover, the Tcp decreased with increases in the DS or the concentration of PyHES. The Tcp of PyHES had a linear relationship with DS, and DLS characterizations indicated that PyHES can form thermo-responsive micellar nanoparticles in aqueous solutions. In addition, PyHES can be further functionalized via click reaction of the propynyl group.