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论文类型：期刊论文

发表时间：2017-09-22

发表刊物：JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

收录刊物：SCIE、EI、PubMed、Scopus

卷号：28

期号：14

页面范围：1525-1537

ISSN号：0920-5063

关键字：Word; hydroxyethyl starch; N-acetyl-cysteine; pH-responsive; oral delivery; drug release

摘要：In this study, a novel type of pH-responsive polymer PyHES-NAC (2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) - (N-acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions. 10.0% DOX was released under artificial gastric fluid after 2h, whereas an immediate release (above 80%) was observed under artificial intestinal fluid. Drug loading capacity of PyHES-NAC was increased by the increase of degree of substitution (DS) of hydrophobic propynyl groups in PyHES, and 41 wt% DOX Loading capacity was the highest value in our study area.