王静

个人信息Personal Information

高级工程师

性别:女

毕业院校:北京科技大学

学位:硕士

所在单位:化工学院

办公地点:西部校区化工实验楼F504

电子邮箱:wangjing2009@dlut.edu.cn

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Selective imaging of Co2+ in live cells with a "turn-on" fluorescent probe

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论文类型:期刊论文

发表时间:2017-02-01

发表刊物:SENSORS AND ACTUATORS B-CHEMICAL

收录刊物:SCIE、EI、Scopus

卷号:239

页面范围:1237-1242

ISSN号:0925-4005

关键字:Fluorescence; High selectivity; pH independent; Cobalt ions; Live cells

摘要:Co2+ fluorescent probes have been scarcely developed in recent years because it is difficult to selectively sense cobalt ions in presence of competitive divalent ions. Herein, is an account of synthesis and characterization of reasonably designed turn-on fluorescent probe SGPB1 with Salicylhydrazide as binding site based on BODIPY adapted fluorophore. It was capable to operate in CHEF mechanism toward Co2+ and showed high sensitivity and remarkable selectivity for Co2+ with 10-fold fluorescence enhancement. Furthermore, cell imaging experiments proved that SGPB1 was suitable for detecting Co2+ in biological environment. (C) 2016 Elsevier B.V. All rights reserved.