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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东北大学
学位：博士
所在单位：化工学院盘锦分院
办公地点：精细化工国家重点实验室E504
电子邮箱：mingbao@dlut.edu.cn
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Isoquinolone Synthesis through SNAr Reaction of 2-Halobenzonitriles with Ketones Followed by Cyclization
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论文类型：期刊论文
发表时间：2015-04-17
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、EI、PubMed、Scopus
卷号：80
期号：8
页面范围：3998-4002
ISSN号：0022-3263
摘要：An efficient method for the synthesis of isoquinolones through base (KOBu)-Bu-t-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)(2)-catalyzed cyclization is described. Isoquinolone derivatives were obtained in satisfactory to good yields.