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Indexed by:期刊论文

Date of Publication:2009-08-01

Journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals:SCIE、PubMed、Scopus

Volume:19

Issue:15

Page Number:4139-4142

ISSN No.:0960-894X

Key Words:Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease

Abstract:Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.