何成

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:南京大学

学位:博士

所在单位:化工学院

电子邮箱:hecheng@dlut.edu.cn

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Binding of anions in triply interlocked coordination catenanes and dynamic allostery for dehalogenation reactions

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论文类型:期刊论文

发表时间:2018-01-28

发表刊物:CHEMICAL SCIENCE

收录刊物:PubMed、SCIE、EI

卷号:9

期号:4

页面范围:1050-1057

ISSN号:2041-6520

摘要:By synergistic combination of multicomponent self-assembly and template-directed approaches, triply interlocked metal organic catenanes that consist of two isolated chirally identical tetrahedrons were constructed and stabilized as thermodynamic minima. In the presence of suitable template anions, the structural conversion from the isolated tetrahedral conformers into locked catenanes occurred via the cleavage of an intrinsically reversible coordination bond in each of the tetrahedrons, followed by the reengineering and interlocking of two fragments with the regeneration of the broken coordination bonds. The presence of several kinds of individual pocket that were attributed to the triply interlocked patterns enabled the possibility of encapsulating different anions, allowing the dynamic allostery between the unlocked/locked conformers to promote the dehalogenation reaction of 3-bromo-cyclohexene efficiently, as with the use of dehalogenase enzymes. The interlocked structures could be unlocked into two individual tetrahedrons through removal of the well-matched anion templates. The stability and reversibility of the locked/unlocked structures were further confirmed by the catching/releasing process that accompanied emission switching, providing opportunities for the system to be a dynamic molecular logic system.