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    武素丽

    • 教授     博士生导师   硕士生导师
    • 性别:女
    • 毕业院校:大连理工大学
    • 学位:博士
    • 所在单位:化工学院
    • 学科:应用化学. 精细化工
    • 办公地点:西部校区实验楼E-422
    • 联系方式:13842603107
    • 电子邮箱:wusuli@dlut.edu.cn

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    Mitochondria specific oxidative injury by near-infrared energy transfer nanoclusters for amplified photodynamic potency

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    论文类型:期刊论文

    第一作者:Xia, Jing

    通讯作者:Chen, QX; Wang, JY (reprint author), Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Dalian 116024, Peoples R China.

    合写作者:Chen, Qixian,Wang, Jingyun,Peng, Xiaojun,Li, Jiaxin,Yao, Qichao,Meng, Zhipeng,Qian, Ming,Cui, Hongyan,Zhang, Liuwei,Li, Yachen,Wu, Suli

    发表时间:2019-12-01

    发表刊物:JOURNAL OF COLLOID AND INTERFACE SCIENCE

    收录刊物:EI、PubMed、SCIE

    卷号:557

    页面范围:45-54

    ISSN号:0021-9797

    关键字:Infrared photosensitizers; Photodynamic therapy; Upconversion nanoparticles; Chlorin e6; Mitochondrion-targeting

    摘要:To promote practical applications of photodynamic therapy, near-infrared (NIR) photosensitizers are manufactured based on fluorescence resonance energy transfer (FRET) between donors of anti-stoke NIR upconversion nanoparticles and acceptors of photodynamic chlorin e6. The manufactured FRET constructs displayed deep tissue penetration and FRET activation under 980 nm irradiation. Furthermore, surface decoration with mitochondria-targeting (4-marboxybutyl) triphenyl phosphonium bromide (TPP) led to mitochondrion-targeted accumulation of singlet oxygen resulting in potent cell apoptosis. Notably, in vivo anti-tumor test validates the complete ablation of intractable solid tumors based on single-dose treatment of our proposed photodynamic constructs. Therefore, the obtained results herald the tempting perspective of our carefully engineered photodynamic constructs, which could have broad utilities in clinical treatment of intractable premalignancies. (C) 2019 Elsevier Inc. All rights reserved.