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Stereoselective Sequential [4+2]/[2+2] Cycloadditions Involving 2-Alkenylindolenines: An Approach to Densely Functionalized Benzo[ b]indolizidines.

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Indexed by:期刊论文

Date of Publication:2018-01-01

Journal:The Journal of organic chemistry

Included Journals:PubMed、SCIE、Scopus

Volume:83

Issue:9

Page Number:5044-5051

ISSN No.:1520-6904

Abstract:A stereoselective sequential [4+2]/[2+2] cycloaddition process involving 2-alkenylindolenines has been developed. This unprecedented protocol allows a rapid access to densely functionalized benzo[ b]indolizidines containing a fully substituted piperidine ring with five contiguous stereogenic centers in good yields with excellent diastereoselectivities. This finding demonstrated the unique synthetic utility of the 2-alkenylindolenine species in the construction of complex polycyclic N-heterocycles.

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