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Indexed by:期刊论文

Date of Publication:2018-12-13

Journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE、Scopus

Volume:2018

Issue:46

Page Number:6469-6473

ISSN No.:1434-193X

Key Words:Pyrazolone; Allenamide; Asymmetric catalysis; Chiral phosphoric acid; Heterocycles

Abstract:We describe a new asymmetric allylic alkylation of pyrazolones, in which an all-carbon quaternary stereocenter with broad substrate scope and good enantioselectivity was generated. The asymmetric addition of pyrazolones to allenamides could be carried out under mild conditions in excellent yields with a relatively low catalyst loading. The allylic products with an enamide structure can be easily transformed to the pyrazolones with other functional groups, which provides a new approach for the asymmetric introduction of new functional groups into the pyrazolone skeleton.