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    刘海龙

    • 副教授       硕士生导师
    • 性别:男
    • 毕业院校:西安交通大学
    • 学位:博士
    • 所在单位:生物医学工程学院
    • 办公地点:大连理工大学创新园大厦A1213
    • 电子邮箱:hlliu@dlut.edu.cn

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    个人简介

    刘海龙,博士,大连理工大学生物医学工程学院副教授,研究方向包括:1)神经功能调控与损伤康复电刺激技术研究;2)细胞网络数学建模;3)生物医学信号处理与分析。2000年7月本科毕业于吉林大学电子工程系生物医学工程专业,2006年12月博士毕业(硕博连读)于西安交通大学生物医学工程研究所。2007年2月到2009年6月在美国匹兹堡大学医学院从事博士后工作。2009年7月至今就职于大连理工大学电子信息与电气工程学部生物医学工程学院。博士期间从事脑机接口技术中意识任务分类的研究。博士后期间从事神经功能电刺激方面的研究,包括以神经电刺激计算机仿真的方法研究基于高频双向电流的神经传导阻断和神经兴奋性调制,以及以麻醉猫为模型研究神经电刺激调制泌尿系统功能和下肢运动功能。在IEEE Transaction on Biomedical Engineering、Journal of Neural Engineering、Scientific Reports等国内外期刊上发表论文30余篇。主持国家自然科学青年基金项目和留学回国人员科研启动基金各1项,参加国家自然科学基金面上项目3项、国家科技支撑计划项目1项、国家重点研发计划重点专项项目1项。


    ● 研究方向:

    1) 神经功能调控与损伤康复电磁刺激技术研究

    (2) 细胞网络建模

    (3) 生物医学信号处理与分析


    ● 讲授课程:

    1) 医学电生理(2009-)

    (2) 数学建模(2021-)

    (3) 生物医学工程仿真实验(2015-2023)

    (4) 数据库技术(2009-2022)

    (5) 生物医学工程原理I(硕士生课部分课时)(2015-)

    (6) 生物医学工程原理II(博士生课部分课时)(2014-)

    (7) 科技英语(2009-2015)


    ● 科研项目:

    (1) “大连理工大学-辽宁省肿瘤医院医工交叉联合基金”重大项目(大连理工大学基本科研业务费项目重大项目科研专题重大科研项目群),胶质瘤患者人脑/脊髓磁共振成像全新诊断方法与治疗设计,DUT20YG121,2020/06-2021/12,30万元,已结题,参与(6/57)

    (2) 科技创新2030—“新一代人工智能”重大项目,2018AAA0100300,新一代神经网络模,2019/12-2024/12,903万/20万元,在研,参加

    (3) 国家自然科学基金面上项目,61573079,基于决策模型和预备电位的运动想象BCI研究,2016/01-2016/12,19.2万元,已结题,参加

    (4) 国家自然科学基金面上项目,31370835,红外弱激光诱发可兴奋细胞动作电位的离子机制研究,2014/01-2017/12,70万元/7万元,已结题,参加

    (5) 国家自然科学基金面上项目,11172060,定量调控干细胞钙信号的剪应力和生化因子实现途径,2012/01-2015/12,68万,已结题,参加

    (6) 国家科技支撑计划项目,2012BAJ18B06,农村数字医疗仪器应用关键技术研究子课题,2012/01-2014/12,60万,已结题,参加

    (7) 国家自然科学青年基金项目,81101165,高频阻断电流对神经的损伤及其离子机制,2012/01-2014/12,23万元,已结题,主持 

    (8) 留学回国人员科研启动基金,高频(kHz)双向电流刺激损伤神经研究,2010/07-2012/12,5万元,已结题,主持

    (9) 大连理工大学基本科研业务费项目重大项目科研专题重大科研项目群,医学与健康工程,DUT18ZD301,2018/01-2019/12,45万元,已结题,参与(6/57)

    (10) 大连理工大学基本科研业务费项目重大项目科研专题重点类项目,促进干细胞培养的膜电位可控电刺激新方法与系统,DUT17ZD222, 2017/01-2018/12,30万元,已结题,主持

    (11) 大连理工大学基本科研业务费专项项目前沿探索与学科交叉科研专题(综合交叉),DUT15QY13,低损伤高频神经电刺激方案设计,2015/01-2016/12,10万元,主持

    (12) 大连理工大学基本科研业务费专项项目学科交叉前沿科研专题(生命+X),高频电流损伤神经及其机制研究,2011/01-2012/12,10万元,主持

    (13) 大连理工大学基本科研业务费专项项目引进人才科研专题,高频(kHz)双向电流诱发轴突膜电位变化中直流分量问题研究,2010/01-2011/12,12万元,主持

    (14)国家重点实验室开放课题,ZX20180025,人大脑及/或心脏芯片相关材料与方法研究,2018.05.25-2020.03.31,20万元,在研,参加3/3

     

    ● 发表论文:

    [1] 孙伟皓, 马建立, 刘海龙, 吴承伟, 张伟, Pengpat K. 细胞力学特性对电刺激响应的研究进展 [J]. 科学通报, 2020, 38(22): 114-122.

    [2] Sun L, Li S, Liu H, Ma X, Duan X, Guan S, Sun C, Sun C. Appropriate electrode positions improve stimulation efficacies in electrical eye stimulations [C]. 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI). 2020: 768-772.

    [3] Sun L, Li S, Liu H, Ma X, Duan X, Guan S, Sun C, Sun C. Effects of electrode sizes and positions on the induced current field in electrical eyeballs stimulations [C]. 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI). 2020: 764-767.

    [4] Zhang Y, Zhu H, Sun P, Sun CK, Huang H, Guan S, Liu H, Zhang H, Zhang C, Qin KR. Laser‐induced graphene‐based non‐enzymatic sensor for detection of hydrogen peroxide [J]. Electroanalysis, 2019, 31(7): 1334-1341.

    [5] Zhou W, Sun L, Zhang X, Chen W, Yang M, Liu H, Li S, Guan S, Sun C, Sun C. Axonal blocking and injuring responses caused by asymmetric high frequency electrical stimulations of frog’s sciatic nerve [C]. International Conference on Biological Information and Biomedical Engineering. 2018: 1-5.

    [6] Wang Y, Liu H, Lin Y, Liu G, Chu H, Zhao P, Yang X, Zheng T, Fan M, Zhou X, Meng J, Sun C. Network-based approach to identify potential targets and drugs that promote neuroprotection and neurorepair in acute ischemic stroke [J]. Scientific Reports, 2017, 7(1): 40137.

    [7] Wang S, Guan S, Wang J, Liu H, Liu T, Ma X, Cui Z. Fabrication and characterization of conductive poly (3,4-ethylenedioxythiophene) doped with hyaluronic acid/poly (l-lactic acid) composite film for biomedical application [J]. Journal of Bioscience and Bioengineering, 2017, 123(1): 116-125.

    [8] Sun L, Li S, Sun C, Liu H. An axonal model for analysis of ionic concentration alterations induced by high frequency electrical stimulations [C]. 2016 9th International Congress on Image and Signal Processing, Biomedical Engineering and Informatics (cisp-Bmei 2016). 2016: 1680-1684.

    [9] Sun L, Li S, Sheng S, Chen L, Liu H, Zhou H, Zhu L, Ren F, Sun C. Preliminary studies on the effects of laser irradiations on nerve injuries caused by high frequency electrical stimulations [C]. 2016 9th International Congress on Image and Signal Processing, Biomedical Engineering and Informatics (cisp-Bmei 2016). 2016: 1717-1721.

    [10] Sun L, Liu H. Steady state membrane potential and sodium current changes during high frequency electrical nerve stimulation [M]. 2015 seventh international conference on measuring technology and mechatronics automation (icmtma 2015). 2015: 1005-1008.

    [11] Zhou H, Sun L, Ren F, Liu H. Energy consumption efficiency at the tip of cardiac spiral waves [C]. 2014 7th International Conference on Biomedical Engineering and Informatics (bmei 2014). 2014: 431-435.

    [12] Sheng S, Sun L, Zhou H, Ren F, Liu H. Nerve injury detection by means of conducting velocity distribution [C]. 2014 7th International Conference on Biomedical Engineering and Informatics (bmei 2014). 2014: 493-497.

    [13] Sun L, Liu H. Modeling analysis of negative effects of high frequency electrical stimulation on axonal behaviors [M]. 2013 35th annual international conference of the ieee engineering in medicine and biology society (embc). 2013: 5958-5961.

    [14] Liu H, Zhu L, Sheng S, Sun L, Zhou H, Tang H, Qiu T. Post stimulus effects of high frequency biphasic electrical current on a fibre's conductibility in isolated frog nerves [J]. Journal of Neural Engineering, 2013, 10(3): 036024.

    [15] 朱林林, 刘海龙, 李林, 盛书磊, 邱天爽. 基于高频双向电流的神经选择性兴奋 [J]. 中国生物医学工程学报, 2012, 31(4): 539-544.

    [16] Tai C, Shen B, Wang J, Liu H, Subbaroyan J, Roppolo JR, de Groat WC. Inhibition of bladder overactivity by stimulation of feline pudendal nerve using transdermal amplitude-modulated signal (tams) [J]. Bju International, 2012, 109(5): 782-787.

    [17] Tai C, Shen B, Chen M, Wang J, Liu H, Roppolo JR, de Groat WC. Suppression of bladder overactivity by activation of somatic afferent nerves in the foot [J]. Bju International, 2011, 107(2): 303-309.

    [18] Tai C, Chen M, Shen B, Wang J, Liu H, Roppolo JR, de Groat WC. Plasticity of urinary bladder reflexes evoked by stimulation of pudendal afferent nerves after chronic spinal cord injury in cats [J]. Experimental Neurology, 2011, 228(1): 109-117.

    [19] Liu H, Zhu L, Tang H, Qiu T. Effects of high frequency electrical stimulation on nerve's conduction of action potentials [C]. 2011 4th International Conference on Biomedical Engineering and Informatics (BMEI). 2011: 1308-1311.

    [20] Chen ML, Shen B, Wang J, Liu H, Roppolo JR, de Groat WC, Tai C. Influence of naloxone on inhibitory pudendal-to-bladder reflex in cats [J]. Experimental Neurology, 2010, 224(1): 282-291.

    [21] Chen M, Shen B, Wang J, Liu H, Roppolo J, de Groat W, Tai C. The role of opiate receptors in the inhibitory pudendal-to-bladder reflex in cats [J]. Journal of Urology, 2010, 183(4): E616-E616.

    [22] Chen M, Shen B, Wang J, Liu H, Roppolo J, de Groat W, Tai C. Bladder overactivity suppressed by electrical stimulation of the foot [J]. Journal of Urology, 2010, 183(4): E616-E616.

    [23] Wang J, Liu H, Shen B, Roppolo JR, de Groat WC, Tai C. Bladder inhibition or excitation by electrical perianal stimulation in a cat model of chronic spinal cord injury [J]. Bju International, 2009, 103(4): 530-536.

    [24] Shen B, Wang J, Liu H, Subbaroyan J, DiUbaldi A, Wahlgren S, Roppolo J, de Groat W, Tai C. Bladder inhibition or excitation by transcutaneous pudendal neuromodulation in cats [J]. Neurourology and Urodynamics, 2009, 28(2): 113-114.

    [25] Liu H, Roppolo JR, de Groat WC, Tai C. Modulation of axonal excitability by high-frequency biphasic electrical current [J]. Ieee Transactions on Biomedical Engineering, 2009, 56(9): 2167-2176.

    [26] Liu H, Roppolo JR, de Groat WC, Tai C. The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current [J]. Ieee Transactions on Biomedical Engineering, 2009, 56(1): 137-146.

    [27] 刘海龙, 王珏, 郑崇勋, 薛建中. 基于频域信息的意识任务分类 [J]. 北京生物医学工程, 2007, 26(1): 52-56.

    [28] Wang J, Yan N, Liu H, Liu M, Tai C. Birain-computer interfaces based on attention and complex mental tasks [M]. Digital human modeling. 2007: 467-473.

    [29] Liu H, Wang J, Zheng C. Multiple mental tasks classification based on nonlinear parameter of mean period using support vector machines [J]. Academic Journal of Xi'an Jiaotong University, 2007, 19(1): 70-72.

    [30] 刘海龙, 王珏, 郑崇勋. 基于可生长自组织映射的意识任务分类 [J]. 西安交通大学学报, 2006, 40(10): 1152-1156.

    [31] 刘海龙, 王珏, 郑崇勋. 基于脑电信号的意识信息提取与表达:脑-机接口 [J]. 中国康复理论与实践, 2005, 11(3): 180-181.

    [32] 刘海龙, 王珏, 郑崇勋. 应用生长、分级的自组织映射模型进行意识任务分类 [J]. 生物物理学报, 2005, 21(6): 443-448.

    [33] 刘海龙, 王珏, 郑崇勋. 基于非线性参数的意识任务分类 [J]. 西安交通大学学报, 2005, 39(8): 900-903.

    [34] Liu HL, Wang J, Zheng CX. Mental tasks classiflcation and their eeg structures analysis by using the growing hierarchical self-organizing map [C]. 2005 First International Conference on Neural Interface and Control   Proceedings. 2005: 115-118.

    [35] Liu H, Wang J, Zheng C, He P. Study on the effect of different frequency bands of eeg signals on mental tasks classification [M]. 2005 27th annual international conference of the ieee engineering in medicine and biology society, vols 1-7. 2005: 5369-5372.

    [36] Liu H, Wang J, Zheng C. Multiple mental tasks classification based on a novel neural network-the evolving tree [J]. Polish Journal of Medical Physics and Engineering, 2005, 11(2): 95-101.

    [37] Liu H, Wang J, Zheng C. Using self-organizing map for mental tasks classification in brain-computer interface [M]. Advances in neural networks – isnn 2005. Berlin / Heidelberg. 2005: 327-332.




    教育经历

    2000.9 -- 2006.12
    西安交通大学       生物医学工程       博士

    1996.9 -- 2000.7
    吉林大学       生物医学工程       学士

    1993.9 -- 1996.7
    吉林省榆树市实验高中       无

    工作经历

    2009.7 -- 至今

    大连理工大学电信学院      高校教师

    2007.3 -- 2009.6

    美国匹茨堡大学      博士后