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Indexed by:期刊论文
First Author:Zhang, Xitao
Correspondence Author:Feng, XJ; Bao, M (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Liaoning, Peoples R China.
Co-author:Feng, Xiujuan,Zhou, Chuancheng,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming
Date of Publication:2018-11-16
Journal:ORGANIC LETTERS
Included Journals:PubMed、SCIE、Scopus
Volume:20
Issue:22
Page Number:7095-7099
ISSN No.:1523-7060
Abstract:A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.