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覃开蓉,教授,博士生导师。分别于1991年和1996年获复旦大学力学学士和流体力学博士学位。毕业后任复旦大学讲师、副教授;2002 年-2004年任日本东京大学医学院博士后;2005 年-2007年任上海交通大学副教授;2007年-2010年任新加坡国立大学研究员;2010年起任大连理工大学教授。中国生物医学工程学会康复工程分会副主任委员;中国生物医学工程学会第十一届理事会科普工作委员会副主任委员;中国生物医学工程学会类器官与器官芯片分会常务委员;中国医工整合联盟常务理事;中国材料学会材料生物力学分会委员;辽宁省医学信息与健康工程学会副理事长;辽宁省医疗器械专家委员会第一届执行委员会委员。主要致力于多尺度血流动力学建模与仿真、生物微流控芯片、医学信息测量及智能控制等领域的科研工作。先后主持或参加国家自然科学基金、科技部、教育部以及企业委托项目30余项。在国内外学术期刊上发表论文150余篇,授权发明专利35件。
代表性科研项目
1.国家重点研发计划项目《基于反搏技术平台的循环系统智能化康复辅具研发》课题“缺血性脑血管疾病智能化康复辅具研发”(Grant No.2020YFC2004400,课题负责人,2020.07-2023.06)
2.国家自然科学基金面上项目《脉动剪应力通过钙-ROS信号互作修复血糖波动引起的内皮细胞损伤》(Grant No.12372304, 负责人,2024.01.01-2027.12.31)
3.国家自然科学基金面上项目《运动引起的血流动力学信号调控内皮损伤修复的体外模型研究》(Grant No.31971243,负责人,2020.01-2023.12)
4.国家自然科学基金面上项目《基于边界效应和驻点流的微流控单细胞捕获与动力学分析》(Grant No.11672065,负责人,2017.01-2020.12)
5.国家自然科学基金面上项目《振荡切应力在运动定量调控颈总动脉内皮功能中的作用》(Grant No.31370948,负责人,2014.01-2017.12)
6.国家自然科学基金面上项目《定量调控干细胞钙信号的剪应力和生化因子实现途径》(Grant No.11172060,负责人, 2012.01-2015.12)
7.国家自然科学基金面上项目《用Hilbert-Huang变换和蛋白质组学技术研究非平稳脉动应力与血管重建》(Grant No. 30670511,负责人,2007-2009)
8.国家自然科学基金面上项目《切应力、周向应力及其协同作用对血管内皮细胞内钙信号的影响》(Grant No. 10472027, 负责人,2005-2007)
9.国家自然科学青年基金项目《高血压引起血管重建过程的血液动力学研究》(Grant No. 19702002, 负责人,1998-2000)
10.国家自然科学基金重点项目《血管重建的生物力学研究》(2002-2005)子课题(Grant No. 10132020, 子课题负责人,2002-2005)
代表性专利
1.覃开蓉,崔祥辰,许颖,王志远,王一腾. 一种临床点滴输液加温与流速监控装置及系统,发明专利,申请号:ZL202210776851.X,申请日:2022.07.04,授权公告号:CN115252961B,授权公告日:2022.11.03
2.覃开蓉,曾效,薛春东,李泳江,刘琨,于苗,吴斯达,杨雨浓,那景童. 一种基于物质浓度的时空梯度分布确定微尺度下变截面扁平微通道高度方向平均流速的方法,发明专利,申请号:ZL202110171127.X,申请日:2021.02.08,授权公告号:CN112964484B,授权公告日:2022.02.15
3.覃开蓉, 杨雨浓, 李泳江, 薛春东, 王宇, 于苗, 王艳霞, 吴斯达, 胡思毓, 赵家铭. 一种研究剪切力和生化因子梯度调控细胞划痕修复的微流控系统及方法,发明专利,申请号:ZL202011278907.6, 申请日:2020.11.16,授权公告号:CN 112964684B,授权公告日:2022.02.15
4.覃开蓉,李泳江,于苗,高树华,王艳霞,于洪建,杨雨浓,薛春东,向程,邵金雨. 用于剪应力与趋化因子定量调控细胞修复实验的微流控系统及方法,发明专利,申请号:ZL201810714997.5, 申请日:2018.07.03,授权公告号:CN108795759B,授权公告日:2021.08.26
5. 覃开蓉,那景童,王宇,李泳江,薛春东. 一种用于血管内皮细胞力学生物学研究的微流控芯片级体外循环系统, 发明专利,申请号: ZL20201021049.1, 申请日:2020.03.24,授权公告号:CN111426821B,授权公告日:2021.07.06
6.覃开蓉,曾德培,于苗,陈宗正,李星汉. 一种基于惠斯通电桥实现高通量单细胞微管吸吮的微流控芯片,发明专利,申请号:ZL201710674698.9,申请日:2017.08.10,授权公告号:CN107574222B,授权公告日:2020.05.19
7.覃开蓉,于苗,陈宗正,于洪建,许政佳. 一种实时精准控制观测点动态生化因子浓度的微流控芯片,发明专利,专利号:ZL201710535360.5,申请日:2017.07.05, 授权公告号:CN107271706B,授权公告日:2018.11.06
8.覃开蓉,高争鸣,陈宗正,王艳霞,于苗,曾德培. 一种基于动态荧光粉浓度确定均匀扁平微通道平均流速和剪切力的方法,发明专利,专利号:ZL201610139388.2,申请日:2016.03.11,授权公告号: CN105628666B,授权公告日: 2018.04.10
9.覃开蓉,陈宗正,于苗,陈燕. 一种基于微流控技术的细胞捕获阵列,发明专利,专利号:ZL201410123036.9,申请日:2014.03.28,授权公告号:CN103923816B,授权公告日:2016.05.25
10.覃开蓉,侯杰,郑晓旭,朱亚冰. 一种模拟振荡血流剪切应力环境的平行平板流动腔系统,发明专利,专利号:ZL201410117574.7,申请日:2014.03.27,授权公告号:CN103881899B,授权公告日:2015.11.18
11.覃开蓉,侯杰,张子威,陈英. 一种颈动脉系统血流动力学与信号分析系统及方法,发明专利,专利号:ZL201210420642.8,申请日:2012.10.29,授权公告号:CN102940486B,授权公告日:2015.01.21
代表性论文
1. Liang LX, Wang XY, Chen D, Sethu P, Giridharan GA, Wang YX, Wang Y*, Qin KR*. Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively. Lab on a Chip, 2024, 24(9): 2428-2439, May 2024 (*Corresponding Author).
2. Wang Y, Gao ZQ, Li YJ*, Mei SH, Tian S, Wu GF, Qin KR*. Double closed-loop feedback control strategy for enhanced external counterpulsation to regulate hemodynamic response of human common carotid artery. Biomedical Signal Processing and Control, 2024, 91: 105914, May 2024 (*Corresponding Author).
3. Liao SF#, Li YJ#, Cao S, Xue CD, Tian S, Wu GF, Chen XM, Chen D, Qin KR*. Hemodynamics of ventricular-arterial coupling under enhanced external counterpulsation: An optimized dual-source lumped parameter model. Computer Methods and Programs in Biomedicine, 2024, 250: 108191, April 2024 (*Corresponding Author).
4. Yu M, Li YJ*, Yang YN, Xue CD, Xin GY, Liu B, Qin KR*. A microfluidic array enabling generation of identical biochemical stimulating signals to trapped biological cells for single-cell dynamics. Talanta, 2024, 267(15): 125172, Jan. 2024 (*Corresponding Author).
5. Zeng X, Xue CD, Li YJ*, Qin KR*. A mathematical model for intracellular NO and ROS dynamics in vascular endothelial cells activated by exercise-induced wall shear stress. Mathematical Biosciences, 2023, 359: 09009, 20 April 2023(*Corresponding Author).
6. Yu M, Li YJ*, Liu SX, Xue CD,Qin KR*. Simplifying biochemical signal transport in steady flows within a single-cell-trapping microchannel by linear low order systems, Microfluidics and Nanofluidics, 2023, 27(2):17, Jan., 2023 (*Corresponding Author).
7. Xue CD*, Qu HC, Zheng GS, Qin KR*, Zhao DW*. Understanding the diffusive transport of nanoparticles in agarose hydrogels. Physics of Fluids, 2022, 34(12): 122001, Dec., 2022 (*Corresponding Author).
8. Na JT#, Xue CD#, Wang YX, Li YJ, Wang Y, Liu B,Qin KR*. Fabricating a multi-component microfluidic system for exercise-induced endothelial cell mechanobiology guided by hemodynamic similarity. Talanta, 2022, 253:123933, Sep., 2022(*Corresponding Author).
9. Xue CD, Zheng ZY, Zheng GS, Zhao DW*, Qin KR*. Vortex evolution patterns for flow of dilute polymer solutions in confined microfluidic cavities, Soft Matter, 2022, 18, 3867-3877, May 2022 (*Corresponding Author).
10. Zeng X, Xue CD*, Chen KJ, Li YJ, Qin KR*. Deep-learning-assisted extraction of height-averaged velocity from scalar signal transport in a shallow microfluidic channel, Microfluidics and Nanofluidics, 2022, 26(5):36, April, 2022 (*Corresponding Author).
11. Chen KJ, Qin KR*. Microbial transport and dispersion in heterogeneous flows created by pillar arrays, Physics of Fluids, 2022, 34(2): 023308, Feb, 2022(*Corresponding Author).
12. Na JT, Hu SY, Xue CD*, Wang YX, Chen KJ, Li YJ, Wang Y, Qin KR*. A microfluidic system for precisely reproducing physiological blood pressure and wall shear stress to endothelial cells, Analyst, 2021,146: 5913- 5922, Aug., 2021(*Corresponding Author).
13. Yuan WM, Xue CD*, Qin KR *.The intracellular calcium dynamics in a single vascular endothelial cell being squeezed through a narrow microfluidic channel, Biomechanics and Modeling in Mechanobiology, 2021, 20(1): 55-67, Feb., 2021(*Corresponding Author).
14. Shen H, Li SQ, Wang Y, Qin KR*. Effects of the arterial radius and the center-line velocity on the conductivity and electrical impedance of pulsatile flow in the human common carotid artery. Medical & Biological Engineering & Computing, 2019, 57(2): 441-451, Feb., 2019 (*Corresponding Author).
15. Chen ZZ, Yuan WM, Xiang C, Zeng DP, Liu B, Qin KR*. A microfluidic device with spatiotemporal wall shear stress and ATP signals to investigate the intracellular calcium dynamics in vascular endothelial cells. Biomechanics and Modeling in Mechanobiology, 2019, 18(1): 189-202, Feb., 2019 (*Corresponding Author).
16. Wang YX, Liu HB, Li PS, Yuan WX, Liu B, Liu ST, Qin KR(*). ROS and NO dynamics in endothelial cells exposed to exercise-induced wall shear stress. Cellular and Molecular Bioengineering, 2019, 12(1): 107-120, Feb., 2019 (*Corresponding Author)
17. Li YJ, Cao T*, Qin KR*. Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow, Microfluidics and Nanofluidics, 2018, 22(8):81, Aug 1, 2018(*Corresponding Author)
18. Li LF, Xiang C, QIN KR*. Modeling of TRPV4-C1-mediated calcium signaling in vascular endothelial cells induced by fluid shear stress and ATP, Biomechanics and Modeling in Mechanobiology, 2015, 14(5): 979-993(*Corresponding Author).
19. Qin KR, Xiang C*, Cao LL. Dynamic modeling for flow-activated Chloride-selective membrane current in vascular endothelial cells. Biomechanics and Modeling in Mechanobiology, 2011, 10(5): 743-754(*Corresponding Author).
20.Qin KR*, Xiang C, Xu Z, Cao LL, Ge SS, Jiang ZL. Dynamic modeling for shear stress induced ATP release from vascular endothelial cells, Biomechanics and Modeling in Mechanobiology, 2008, 7(5): 345-353(*Corresponding Author).
Educational Experience
Work ExperienceMore>>
Research Focus
Multiscale Modeling and Simulation in Hemodynamics
Biomicrofluidics
Medical Information Measurement and Intelligent Control