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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：光电工程与仪器科学学院院长、党委副书记
其他任职：辽宁省先进光电子技术重点实验室副主任，大连市新型功能材料与光电子器件重点实验室主任，中国超材料学会理事，中国机械工程学会极端制造分委员会委员，国际先进材料学会会士，Microsystems&Nanoengineering、chemosensors等期刊副编辑
性别：男
毕业院校：布里斯托尔大学
学位：博士
所在单位：光电工程与仪器科学学院
学科：光学工程. 电磁场与微波技术. 光学. 测试计量技术及仪器. 精密仪器及机械
办公地点：研教楼706
联系方式：0411-84706156
电子邮箱：caotun1806@dlut.edu.cn
Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y-Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion
点击次数：
论文类型：期刊论文
发表时间：2013-12-01
发表刊物：JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
收录刊物：SCIE、EI、Scopus
卷号：135
期号：12
ISSN号：0148-0731
关键字：dynamic biochemical signal; transport; steady flow; shallow Y-shaped microfluidic channel; Taylor-Aris dispersion; molecular diffusion
摘要：Dynamic biochemical signal control is important in in vitro cell studies. This work analyzes the transportation of dynamic biochemical signals in steady and mixing flow in a shallow, Y-shaped microfluidic channel. The characteristics of transportation of different signals are investigated, and the combined effect of transverse diffusion and longitudinal dispersion is studied. A method is presented to control the widths of two steady flows in the mixing channel from two inlets. The transfer function and the cutoff frequency of the mixing channel as a transmission system are presented by analytically solving the governing equations for the time-dependent Taylor-Aris dispersion and molecular diffusion. The amplitude and phase spectra show that the mixing Y-shaped microfluidic channel acts as a low-pass filter due to the longitudinal dispersion. With transverse molecular diffusion, the magnitudes of the output dynamic signal are reduced compared to those without transverse molecular diffusion. The inverse problem of signal transportation for signal control is also solved and analyzed.