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    王丽丽

    • 副教授     硕士生导师
    • 主要任职:无
    • 性别:女
    • 毕业院校:大阪市立大学
    • 学位:博士
    • 在职信息:在职
    • 所在单位:生物工程学院
    • 学科:生物工程与技术 微生物学
    • 办公地点:生物工程学院405
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    Hypolipidemic Activity of Camellia euphlebia Flower Extract in High-fat-fed Mice

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    论文类型:期刊论文

    第一作者:He, Dongye

    通讯作者:Xu, YP (reprint author), Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China.; Xu, YP (reprint author), Dalian Univ Technol, Minist Educ, Ctr Food Safety Anim Origin, Dalian 116620, Peoples R China.

    合写作者:Zhang, Ping,Sai, Xuan,Li, Xiaoyu,Wang, Lili,Xu, Yongping

    发表时间:2017-12-01

    发表刊物:PLANT FOODS FOR HUMAN NUTRITION

    收录刊物:SCIE、PubMed、Scopus

    卷号:72

    期号:4

    页面范围:372-379

    ISSN号:0921-9668

    关键字:Camellia euphlebia flowers; Hyperlipidemia; Antioxidant; Lipid accumulation; Phytochemicals

    摘要:Camellia euphlebia (family, Theaceae) has been used for the prevention and treatment of cardiovascular diseases in Southern China. However, there has been no report on the hypolipidemic activity of Camellia euphlebia flower. This study evaluated the hypolipidemic activity of different preparation of Camellia euphlebia flower extracts using in vivo models. Mice intragastrically administered aqueous extract at 400 mg/kg dose or ethanol extract at 100 and 400 mg/kg doses of Camellia euphlebia flower for 28 days exhibited significant decreases in the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol, while displaying increased level of high-density lipoprotein cholesterol in the serum. The Camellia euphlebia flower extracts also improved the antioxidant ability of hyperlipidemic mice as well as protecting the animals against liver damage by lowering the level of glutamic-pyruvic transaminase activity. Furthermore, 400 mg/kg ethanol extract effectively down-regulated the mRNA levels of fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and glycerol-3-phosphate acyl transferase, suggesting that Camellia euphlebia flower extract may potentially inhibit lipid accumulation in the liver by regulating the expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and glycerol-3-phosphate acyl transferase. These results provided support for the potential hypolipidemic activity of Camellia euphlebia flower and could partly explain the basis of using Camellia euphlebia for the treatment of hyperlipidemia.