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Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

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Indexed by:期刊论文

Date of Publication:2016-09-14

Journal:PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Included Journals:SCIE、PubMed、Scopus

Volume:18

Issue:34

Page Number:23458-23461

ISSN No.:1463-9076

Abstract:GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.

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