点击次数：

论文类型：期刊论文

发表时间：2017-01-01

发表刊物：INORGANIC AND NANO-METAL CHEMISTRY

收录刊物：SCIE

卷号：47

期号：11

页面范围：1509-1519

ISSN号：2470-1556

关键字：Mn(II) complex; Derivative; DNA binding; DNA damage

摘要：The novel metal coordination polymer [Mn(L)(2)(H2O)(2)]n, was synthesized and characterized. Fluorescence and UV absorption spectroscopy indicates that the ligand and Mn(II) comploud can bind to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the ligand and Mn(II) complex to cleave the HL-60 plasmid DNA. Apoptotic study shows the complexes exhibited significant cancer cell (JEKO-1 and KB) inhibitory rate. The results indicate that the complexe and the ligand bound to DNA with different binding affinity, in the order the Mn(II) complex > the ligand. Oxygen and nitrogen atoms which chelated with Mn(II) forming hydrogen bonds with N6 atom of adenine and O4 atom of thymine to affect the stability of DNA from Molecular docking study.