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论文类型：期刊论文

发表时间：2018-12-15

发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录刊物：SCIE、PubMed、Scopus

卷号：28

期号：23-24

页面范围：3665-3669

ISSN号：0960-894X

关键字：N-chlorohydantoins; Zwitterionic compounds; Chemical synthesis; Antibacterial application

摘要：Two novel zwitterionic N-chlorohydantoin biocides, containing an N-chlorohydantoin unit and a sulfobetaine unit or a carboxybetaine unit, were chemically synthesized and characterized. Using the quaternary ammonium N-chlorohydantoin as control, the antibacterial activity of synthetic zwitterionic N-chlorohydantoins was challenged and the antibacterial data showed that carboxybetaine N-chlorohydantoin exhibited distinctively higher biocidal efficacy than QA counterpart, while sulfobetaine N-chlorohydantoin displayed slightly inferior antimicrobial efficacy. Our results may inspire further exploration of more zwitterionic N-chlorohydantoin analogs for antibacterial application.