李淑晶 博士 硕士生导师，荣获大连市青年科技之星以及星海骨干等称号。主要研究方向为恶性肿瘤发生发展分子机制及肿瘤治疗过程中耐药性研究。目前发表研究性论文30余篇，荣获包括辽宁省自然科学二等奖、辽宁省医学科技一等奖等多个奖项，主持项目经费累计近100万元。

研究方向：

       蛋白质化学修饰对恶性肿瘤发生发展的调控作用

       周期节律紊乱与恶性肿瘤发生发展间关系

       肿瘤标志物筛选及在诊疗中应用

       肿瘤耐药机制研究

常年招收生物学、生物工程、生物化工、生物与医药方向研究生，联系方式lsj@dlut.edu.cn

√ 代表性论文（*为通讯作者）

1.       Yang Yangyang, Binggong Zhao, Linlin Lv, Yuxi Yang, and Shujing Li*, Huijian Wu,  FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1, Cell Death Discovery, 2021, 7:328

2.       Sattout Aman, Yanan Li, Yunmeng Cheng, Yuxi Yang, Linlin Lv, bowen li, Kangkai Xia, Shujing Li*, Huijian Wu, DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9, Cell Death Discovery, 2021, 7: 351

3.       Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu. P300-mediated acetylation of the transcriptional factor ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1, Npj Precision Oncology, 2021, 5(1):20.

4.       Yangyang Yang, Shujing Li, Bowen Li, Yanan Li, Kangkai Xia, Aman Sattout, Yuxi Yang, Bashir Ahmad, Binggong Zhao, Huijian Wu. FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα, CANCER LETTER, 2021, 502: 108-119

5.       Bowen Li, Liying Mu, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Bashir Ahmad, Shujing Li*, Huijian Wu*. TIMELESS inhibits breast cancer cell invasion and metastasis by down-regulating the expression of MMP9, Cancer Cell Int., 2021, 21:38

6.       Shujing Li, Wanping Guo, Huijian Wu*, The role of post-translational modifications in the regulation of MCL1, Cellular Signalling, 2021, 81: 109933

7.       Shujing Li, Jin Wang, Gaolei Hu, Sattout Aman, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Miao Wang, Huijian Wu. SUMOylation of MCL1 Protein Enhances Its Stability by Regulating the Ubiquitin-Proteasome Pathway, Cellular Signalling, 2020, 73:109686.

8.       Wang Jian, Li Shujing（并1）, Li Xiahui, Li Bowen, Li Yanan, Xia Kangkai, Yang Yuxi, Aman Satman, Wang Miao, Wu Huijian. Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression. Cancer Cell Int. 2019, 19:182

9.       Shujing Li, Miao Wang, Xinjian Qu, Zhaowei Xu, Yangyang Yang, Qiming Su, Huijian Wu*, SUMOylation of PES1 Upregulates its Stability and Function via Inhibiting its Ubiquitination, Oncotarget, 2016, 7(31): 50507-50519

10.    Xiao Jiang, Mei Zhang, Xiaoyan Bai, Shujing Li*, Huijian Wu. Association between 17q25.3-rs6465657 polymorphism and prostate cancer susceptibility: a meta-analysis based on 19 studies, Onco Targets and Therapy, 2016, 9: 4491-4503.

11.    Xiang Ao, Shujing Li, Zhaowei Xu, Yangyang Yang, Min Chen, Xiao Jiang, Hujian Wu*, Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha, Oncotarget, 2016, 7(18): 26220-26234

12.    Hailian Bi， Shujing Li（并1）， Xinjian Qu， Miao Wang， Xiaoyan Bai， Zhaowei Xu， Xiang Ao， Zhaojun Jia， Yangyang Yang， Hujian Wu*，DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase，Cell Death and Disease，2015, 6: e1891

13.    Hailian Bi, Shujing Li（并1）, Miao Wang, Zhaojun Jia, Alan K. Chang, Pengsha Pang, and Huijian Wu*. SUMOylation of GPS2 protein regulates its transcription-suppressing function, Mol. Bio. Cell, 2014, 25(16): 2499-2508.

14.    Shujing Li, Xiang Ao, Huijian Wu*. The role of circadian rhythm in breast cancer. Chin J Cancer Res, 2013;25(4):442-450

15.    Shujing Li, Miao Wang, Xiang Ao, Alan K. Chang, Chunhua Yang, Feng Zhao, Hailian Bi, Ying Liu, Liyun Xiao, Huijian Wu*. CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptorα. Oncogene, 2013, 32(41): 4883-4891