刘宇博,教授,博士生导师,入选国家级青年人才项目,兴辽英才“青年拔尖”项目,主要研究方向为糖生物学和糖化学生物学。
糖链是继核酸、蛋白质之后的“第三条生命之链”,与癌症等重大疾病发生发展息息相关。针对生物体O-GlcNAc糖链特异性标记和功能解析这一科学问题,构建了整套活细胞染色质糖蛋白标记的化学基因组学策略。实现了糖蛋白生物正交标记与高通量活性分析,组学水平揭示了染色质O-GlcNAc特征糖基化作为新的表观密码(糖密码)的重要功能,发现了多个肿瘤治疗新靶点。创制了特定O-GlcNAc糖基化的高效抑制剂分子,成功干预肿瘤异常O-GlcNAc糖基化,抑制多种类型肿瘤进展。研究工作在领域内形成鲜明特色,开辟了利用化学标记跨维度研究染色质糖密码功能的新途径,为糖生物学研究提供新范式和新策略。
发表高水平论文50余篇,包括中科院一区10篇,自然指数期刊3篇,主持国家自然科学基金等项目十余项,参与国家重大科技专项等。
代表性研究论文:
1. Liu, Yubo; Chen, Qiushi; Zhang, Nana; Zhang, Keren; Dou, Tongyi; Cao, Yu; Liu, Yimin; Li, Kun; Hao, Xinya; Xie, Xueqin; Li, Wenli; Ren, Yan*; Zhang, Jianing*; Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response, Nature Communications, 2020, 11, 5898.
2. Liu, Yajie; Yu, Kairan; Kong, Xiaotian; Zhang, Keren; Wang, Lingyan; Zhang, Nana; Chen, Qiushi; Niu, Mingshan; Li, Wenli; Zhong, Xiaomin; Wu, Sijin*; Zhang Jianing*; Liu, Yubo*; FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer. Science Advances, 2023, 9, eadg7112.
3. Wang, Lingyan; Li, Guofang; Zhou, Ziyu; Ge, Chang; Chen, Qiushi; Liu, Yajie; Zhang, Nana; Zhang, Keren; Niu, Mingshan; Li, Wenli; Zhong, Xiaomin; Wu, Sijin*; Zhang Jianing*; Liu, Yubo*; Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263. Oncogene, 2023, 42, 2329-2346.
4. Liu, Yangzhi; Yu, Kairan; Zhang, Keren; Niu, Mingshan; Chen, Qiushi; Liu, Yajie; Wang Lingyan; Zhang, Nana; Li, Wenli; Zhong, Xiaomin; Li, Guohui; Wu Sijin*; Zhang Jianing*; Liu, Yubo*; O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance. EMBO Reports, 2023, 24, e56458.
5. Wu, Qiong; Zhang, Cheng; Zhang, Keren; Chen, Qiushi; Wu, Sijin; Huang, Huang; Huang, Tianmiao; Zhang, Nana; Wang, Xue; Li, Wenli; Liu, Yubo*; Zhang, Jianing*; ppGalNAc-T4-catalyzed O-Glycosylation of TGF-β type II receptor regulates breast cancer cells metastasis potential, Journal of Biological Chemistry, 2021, 296, 100119.
Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Title : 智能生物制造教育部重点实验室
Gender:Male
Alma Mater:大连理工大学
Degree:Doctoral Degree
School/Department:化工海洋与生命学院
Discipline:Biochemistry and Molecular Biolog. Biochemical Engineering. Chemical Biology
Business Address:大连理工大学 智能生物制造教育部重点实验室 生命科学与药学系
Contact Information:liuyubo@dlut.edu.cn
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