史美云，大连理工大学，生命科学与药学学院，副教授

教育经历
2010/09-2015/06，吉林大学，药理学，博士，导师：顾景凯
2006/09-2010/06，吉林大学，生命科学与技术基地班（生物药学），学士

工作经历
2015/07-2020/12，大连理工大学，生命与医药学院，讲师

2021/01-至今，大连理工大学，生命科学与药学学院，副教授

研究方向
药物代谢与药物动力学；液相色谱串联质谱技术在药代动力学中的应用；纳米制剂药代动力学研究

主持科研项目
1.国家自然科学基金青年基金，81703607，基于Massall技术的从亚细胞到整体水平的PEG化吉西他滨药代动力学研究，2018/01-2020/12，20.1万，已结题，主持。
2.辽宁省自然科学基金指导计划（博士启动基金），20170520115，多尺度PEG化吉西他滨HPLC-HR-MS/MS分析方法建立及其纳米药代动力学研究，2017/09-2019/09，3万，已结题，主持。

3.辽宁省科技计划联合基金面上项目，2023/12-2025/11，8万，在研，主持。

4.辽宁省肿瘤医院“肿瘤学+”开放课题，2024/01-2026/12，60万，在研，主持。

发表文章

1. Meiyun Shi, Xinyue Zheng, Ning Zhang, Yufeng Guo, Meichen Liu, Lei Yin. Overview of sixteen green analytical chemistry metrics for evaluation of the greenness of analytical methods. TrAC Trends in Analytical Chemistry.2023,166, 117211. 一作，中科院1区TOP，IF=13.1

2.Meiyun Shi, Xinyue Zheng, Hui Jiang, Yuncheng Ge, Ning Zhang, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin. Unraveling the in vivo biological fate of mPEG2000-PDLLA2500-COOH diblock copolymers by LC-MS/MS based on CID in source technique. Anal Chim Acta. 2023, 1267:341375. 一作，中科院1区TOP，IF=6.2 

3. Lei Yin, Tianming Ren, Shiying Zhao, Meiyun Shi*, Jingkai Gu*. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MS^ALL technique. Talanta. 2020, 206:120184. （SCI, IF= 6.556, 中科院2区，JCR1区）

4. Meiyun Shi, Lei Yin, Yantong Sun, Can Wang, Lanlan Cai, Tinglan Zhang, J.Paul Fawcett, Xiaoli Gao*, Jingkai Gu*.Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC–MS/MS Method, Clinical Pharmacokinetics, 2022, 61(11):1571-1583.（SCI, IF=5.577 , 中科院1区，JCR1区）

6. Xiangyi Xu, Xuanxi Jiang, Meiyun Shi*, Lei Yin*. Mass spectrometry-based techniques for single-cell analysis. Analyst. 2023, 148(16):3690-3707. 通讯，中科院2区，IF=4.2

6. Meiyun Shi, Qiuhong Jiang, Di Lu, Xinyue Zheng, Xujian Duan, Xiangyi Xu, Yajun Liu, Hongyu Xue, Lei Yin*. Quantitative analysis of polypropylene glycol polymers by liquid chromatography tandem mass spectrometry based on collision induced dissociation technique. J Chromatogr A. 2022, 1676:463214. （SCI, IF= 4.601, 中科院2区，JCR1区）

7. Meiyun Shi, Qiuhong Jiang, Qiushi Lyu, Zhengting Yuan, Lili Deng, Lei Yin*. A LC-MS³ strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity. Anal Methods. 2021, 13(38):4478-4484. （SCI, IF= 3.532, 中科院2区，JCR1区）

8. Meiyun Shi, Mengyao Xu, Lei Yin*, Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats. J Pharm Pharmacol. 2020, 72(8):1061-1071. (SCI, IF= 4.81, 中科院2区，JCR2区）

9. Meiyun Shi, Xinyue Zheng, Di Lu, Xujian Duan, Yongqi Wang, Yajun Liu, Hongyu Xue, Lei Yin*. Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects. J Pharm Biomed Anal. 2022, 214:114751. （SCI, IF= 3.571, 中科院2区，JCR2区）

10. Xujian Duan, Di Lu, Xinyue Zheng, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin^#, Meiyun Shi^#. Development and validation of an LC-MS/MS assay with multiple stage fragmentation for the quantification of alachlor in McF-7 cells. J Chromatogr B. 2023; 1214:123550. (SCI, IF= 3 中科院3区，JCR2区）

11. Xinyue Zheng, Xujian Duan, Di Lu, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin^#, Meiyun Shi^#. Cellular toxicity and pharmacokinetic study of butachlor by ultra-performance liquid chromatography-tandem mass spectrometry based on tandem mass spectrometry cubed technique. Journal of Separation Science. 2023;46(1):e2200725. (SCI, IF= 3.1, 中科院3区，JCR2区）

12. Meiyun Shi, Xujian Duan, Xinyue Zheng, Di Lu, Yuncheng Ge, Ning Zhang, Yajun Liu, Jiansong You, Hongyu Xue*, Lei Yin*, Quantification of human serum albumin by combining chymotrypsin/ trypsin digestion coupled with LC-MS/MS technique. Analytical Biochemistry, 2023, 680: 115316. (SCI, IF= 2.9, 中科院3区）

13. Meiyun Shi*, Jiang H, Yin L, Liu Y, Xu M. Development of an UPLC-MS/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats. J Chromatogr B 2019, 1125:121716. (SCI, IF= 3, 中科院3区，JCR2区）

14. Meiyun Shi, Yan Yang, Jingkai Gu, et al., Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study. Journal of Separation Science. 2015, 38, 1351-1357 (SCI, IF= 3.614, 中科院3区，JCR2区）

15. Meiyun Shi, Yan Yang, Jingkai Gu, et al. Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography-tandem mass spectrometry, Journal of chromatography B, 2014,951-952,129-134 (SCI, IF= 3.318, 中科院3区，JCR2区）

16. Shi Meiyun , Lei Yin, Cai Lanlan, Wang Can，Liu Xidong，Zhao Sen，Sun Yantong，Fawcett J. Paul，Zhao Limei，Yang Yan*，Gu Jingkai*，LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study，Chemical Research in Chinese Universities, 2014, 30(6):900-904. (SCI, IF= 2.726, 中科院3区，JCR3区）

17. Shi Meiyun, Zhao Xiaojun, Wang Tingting, Yin Lei, Li Yanyan. A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma. J Chromatogr Sci. 2018, 10; 1;56(9):828-834. (SCI, IF= 1.555, 中科院4区，JCR4区）

18. Lei Yin^#, Tingting Wang^#, Meiyun Shi^#, Ying Zhang, Xiaojun Zhao, Yan Yang*, Jingkai Gu*, Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring, J. Sep. Sci. 2016,03;39(5):964-72. (SCI, IF= 3.614, 中科院3区，JCR2区）

19. Lei Yin^#, Meiyun Shi^#, Tingting Wang, Miaomin Zhang, Xiaojun Zhao, Ying Zhang, Jingkai Gu*, A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring, Chromatographia, 2017,01,137-143. SCI：000392315400017, IF：2.213, 他引：6次，JCR:Q3（CHEMISTRY, ANALYTICAL）

20. Lei Yin, Meiyun Shi, Yantong Sun, Xiaocheng Sun, Huan Meng, J.Paul Fawcett, Yan Yang*, Jingkai Gu*. A liquid chromatography–tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B, 2013,06; 931,12–16. (SCI, IF= 3.318, 中科院3区，JCR2区）

21. Zhang Tinglan, Shi Meiyun, Di Xin*, Gu Jingkai. Fragmentation pathways of five estrogens using electrospray ionization quadrupole time-of-flight mass spectrometry. Acta pharmaceutica Sinica, 2014, 49,507-512.

22. Nana Zhang, Tong Zhu, Kairan Yu, Meiyun Shi, Xue Wang, Lingyan Wang, Tianmiao Huang, Wenli Li, Yubo Liu* and Jianing Zhang*, Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells, Cell Death and Disease, 2019, 10:343 

23. Lei Yin, Yun-hui Zhang, Sen Zhao, Long-mei Cheng, Mei-yun Shi, Yan Yang*, Yan-tong Sun*, Xi-dong Liu, J.Paul Fawcett. Rapid quantification of astilbin in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Chemical Research in Chinese Universities. 2013,12; 29,1078-1082.

24. Yin Lei, Su Chong, Ren Tianming, Meng Xiangjun, Shi Meiyun, Paul Fawcett J, Zhang Mengliang, Hu Wei, Gu Jingkai*. MS^All strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. 2017,11, 142(22):4279-4288.

25. Shasha Liu, Xiaoxia Liu, Xun Zhang, Meiyun Shi, Hecheng Wang, Yajun Liu*. Identification and biological evaluation of glycol diaryl ethers as novel anti-cancer agents through structure-based optimization of crizotinib. Chemical Biology & Drug Design, 2018,92,1972-1980.

26. Yubo Liu, Yu Cao, Xiaoqing Pan, Meiyun Shi, Qiong Wu, Tianmiao Huang, Hui Jiang, Wenli Li & Jianing Zhang*. O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance. Cell Death & Disease, 2018,485.

27. Lei Yin, Meiyun Shi, Jingkai Gu*, et al. A liquid chromatography-tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study, Journal of chromatography B, 2013,931,12-16

28. Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J. Paul Fawcett, Jingkai Gu*, Limei Zhao. Determination of landiolol, an ultra-short-acting beta(1)-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography B, 2012,891,7-11

29. Man Yang, Chenyao Li, Yajing Li, Chen Cheng, Meiyun Shi, Lei Yin, Hongyu Xue, Yajun Liu. Design, synthesis, biological evaluation and molecular docking study of 2,4-diarylimidazoles and 2,4-bis(benzyloxy)-5-arylpyrimidines as novel HSP90 N-terminal inhibitors. J Enzyme Inhib Med Chem. 2022, 37(1):2551-2565.

30. Yajun Liu *, Xiaoxia Liu, Lihong Li, Rui Dai, Meiyun Shi, Hongyu Xue*, Yong Liu and Hecheng Wang, Identification and Structure-Activity Studies of 1,3-Dibenzyl-2-aryl imidazolidines as Novel Hsp90 Inhibitors, Molecules 2019, 24, 2105

31. 药学学报，2023 58 (4):844-851（通讯）

32. 药学学报，2023 58 (4):834-843（通讯）

专利
顾景凯, 尹磊, 史美云, 孟祥骏, 宿崇, 彭雯雯, 陆欢, 林文孩, 杨艳, 景遐斌, 一种生物样本中PEG化药物的定量测定方法, 2017.3.29，中国,ZL201510356568.1。

指导研究生

指导硕士生11人，毕业4人。1人获校级优秀毕业论文。在校学生中有1人获大连理工大学“优研标兵”(盘锦校区唯一，学院首次)及国家奖学金。