孙文，大连理工大学精细化工国家重点实验室研究员、博士生导师。2017年12月毕业于德国马普高分子研究所 (Max-Planck-Institute for Polymer Research)，获化学博士学位。2018年3月加入大连理工大学精细化工国家重点实验室任副研究员，2020年12月任研究员，博士生导师。国家优秀青年基金获得者（2020年）。目前担任精细化工国家重点实验室主任助理、中国石油和化学工业联合会高端专用化学品理事会副秘书长、中国化工学会精细化工专业委员会青年委员。 入选“辽宁省百千万人才工程”培养计划。主持国家自然科学基金面上项目和青年项目、中高校科技领军人才团队项目、辽宁省自然科学基金等多项基金。

针对环境、生命科学中一系列分析检测及肿瘤治疗的关键科学问题，近年来开展了以功能染料为核心用于疾病检测及光驱动治疗的研究工作。共发表SCI论文50余篇。以第一或通讯作者在Nature Chem.、J. Am. Chem. Soc. (2篇)、Angew. Chem. Int. Ed (4篇)、Adv. Mater. (3篇)、Matter、Adv. Funct. Mater. (6篇)、Adv. Sci. (3篇)、Biomaterials (5篇)、Small (3篇)、 Chem. Rev. 、 Accont. Chem. Res. 、Coordin. Chem. Rev. 等国际知名学术期刊上发表研究成果。1篇文章入选Hot paper, 5篇入选ESI高被引，多篇文章分别被 JACS、Adv. Mater. 和Adv. Sci.杂志选为封面/内封面。SCI引用9000余次,H 因子49。担任20余种国内外学术期刊的审稿人。获2019年度中国石油和化学工业联合会科技进步一等奖，2023年度侯德榜化工科学技术青年奖。

学术兼职：担任Frontiers in Chemistry (IF: 5.22,  JCRQ2) 期刊副主编，Smart Molecules 及中南大学学报（国际版）编委。

 

 

Selected Publications

2023

 

57. In Vivo Metallophilic Self-assembly of a Light-activated Anticancer Drug. X. Zhou, P. Wang, V. Ramu, L. Zhang, S. Jiang, X. Li, S. Abyar, P. Papadopoulou, Y. Shao, L. Bretin, M. A Siegler, F. Buda, A. Kros, J. Fan, X. Peng, W. Sun*, S. Bonnet*. Nature Chem. 2023, 15, 980-987.

 

56. Near-Infrared Light-Activated Ruthenium Complex-based Photocage for Cancer Phototherapy. G. He, M. He, R. Wang, X. Li, H. Hu, D. Z. Wang, Y. Lu, N. Xu, J. Du, J. Fan, X. Peng, W. Sun*. Angew. Chem. Int. Edit. 2023, 62, e202218768 (Front Cover).

 

55. Liposomal Enzyme Nanoreactors based on Nanoconfinement for Efficient Anti-Tumor Therapy. R.Wang,Y.Yu, M. Gai, A. M. Maroto, S. Morsbach, X. Xia, M. He, J. Fan, X. Peng, K. Landfester*, S. Jiang*, W. Sun*. Angew. Chem. Int. Edit. 2023, 62, e202308761.

 

54. Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Photoactivated Chemotherapy Prodrugs for the Treatment of Brain Tumors. L. Zhang, P. Wang, X. Zhou, L. Bretin, X. Zeng, Y. Husiev, E. Rivas, L. Wijaya, T. Biver, S. Dévédec, W. Sun,* S. Bonnet*. J. Am. Chem. Soc. 2023, 145, 14963-14980.

 

53. A Fluorescent Chemosensor for Long-Term Tracking of Cancer Cell Metastasis and Invasion via Enzyme-Activated Anchoring. T. Liu, X. Xia, R. Wang, X. Rong, Z. Su, J. Du, J. Fan, X. Peng, W. Sun*. Adv. Funct. Mater. 2023, DOI:10.1002/adfm.202304347.

 

52. The Construction of Polyphotocage Platform for Anticancer Photochemotherapy. M. He, R. Wang, R. Zhang, P. Miao, P. Wang*, Z. Wei, X. Leng, Y. Li*, J. Fan, X. Peng, W. Sun*. Adv. Funct. Mater. 2023, 33, 2300780.

 

51. Heptamethine Cyanine Dyes with Ultra-efficient Excited-state Nonradiative Decay for Synergistic Photothermal Immunotherapy. X. Xia, C. Shi, S. He, R. Wang, Z. Zhang, Y. Hu, J. Cao, T. Liu, D. Zhou, W. Sun*, J. Fan*, X. Peng. Adv. Funct. Mater. 2023, https://doi.org/10.1002 /adfm.202300780

 

50. The chronological evolution of fluorescent GPCR probes for bioimaging. Y. Wu, B. Zhang*, H. Xu, M. He, X. Deng, L. Zhang, Q. Dang, J. Fan, Y. Guan*, X. Peng, W. Sun*. Coordin. Chem. Rev., 2023, 480, 215040

 

49. Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light. Z. Su, D. Xi, Y. Chen, R. Wang, X. Zeng, T. Xiong, X. Xia, X. Rong, T. Liu, W. Liu, J. Du, J. Fan, X. Peng, W. Sun*. Small 2023, 19, 2205825.

 

48. Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4‐Mediated Macropinocytosis, C. Yang, F. Zhang, F. Chen, Z. Chang, Y. Zhao, D. Shao, W. Sun*, W. Dong, Z Wang*. Adv. Healthcare Mater. 2023, 12, 2202064.

 

47. Recent Progress of Self-Immobilizing and Self-Precipitating Molecular Fluorescent Probes for Higher-Spatial-Resolution Imaging.J. Yan, H. Liu, Y. Wu, B. Niu, X. Deng, L. Zhang, Q. Dang, Y. Wang, X. Lu, B. Zhang*, W. Sun*.  Biomaterials, 2023, 301, 122281.

 

46. The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter. H. Liu, T. Liu, Q. Qin, B. Li, F. Li, B. Zhang*, W. Sun* Analyst, 2023, 148, 3952-3970.

 

45. Near-Infrared and Highly Photostable Squaraine-based Nanoparticles for Photoacoustic Imaging Guided Photothermal Therapy. X. Rong, X. Xia, R. Wang, Z. Su, T. Liu, Z. Zhang, S. Long, J. Du, J. Fan, W. Sun*, X. Peng. Dyes Pigments, 2023, 211, 111055.

2022

44. Gene Therapy of Brain Cancer by Drug Delivery Nanocapsules. X.-Q. Zhou, R. Wang, W Sun*, S. Bonnet*. Matter, 2022, 3, 2502. 

43. Recent Advances in Redox-Responsive Nanoparticles for Combined Cancer Therapy. Y. Yang, W. Sun*, Nanoscale Advances, 2022, 4, 3504-3516. Invited Minireview.

42.Tumor-microenvironment triggered signal-to-noise boosting nanoprobes for NIR-IIb fluorescence imaging guided tumor surgery and NIR-II photothermal therapy. P. Wang, J. Li, M. Wei, R. Yang, K. Lou, Y. Dang. W. Sun*, F. Xue, X. Liu. Biomaterials, 2022, 287, 121636.

41. H-Aggregates of Prodrug-Hemicyanine Conjugate for Enhanced Photothermal Therapy and Sequential Hypoxia-Activated Chemotherapy, X. Li, M. Yang, J. Cao, H. Gu, W. Liu, T. Xia, W. Sun*, J. Fan*, X. Peng. ACS Mater. Lett. 2022, 4, 724-732.

40. A Glutathione Activatable Pro-drug-photosensitizer for Combined Chemotherapy and Photodynamic Therapy. Y. Yang, Y. Zhang, R. Wang, X. Rong, T. Liu, X. Xia, J. Fan, W Sun*, X. Peng. Chinese Chem. Lett. 2022, 33, 4583-4586.

39. Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement. M. He, R. Wang, P. Wan, H. Wang, Y. Cheng, P. Miao, Z. Wei, X. Leng, Y. Li*, J. Du, J. Fan, W. Sun*, and X. Peng. Biomacromolecules 2022, 23,1733-1744. (Front Cover)

38. Red-Light-Triggered Self-Destructive Mesoporous Silica Nanoparticles for Cascade-Amplifying Chemo-Photodynamic Therapy Favoring Antitumor Immune Responses. Y. Yang, F. Chen, N. Xu, Q.Yao, R. Wang, X. Xie, F. Zhang, Y. He e, D. Shao *, W. Dong, J. Fan, W. Sun *, X. Peng. Biomaterials, 2022, 281, 121368.

37. A Sulfur-Substituted Hemicyanine for Cancer Photothermal Therapy with-out Influence of Intracellular Viscosity. X. Xia, R. Wang, Y. Hu, Q. Yao, S. Long, W. Sun*, J. Fan*, X. Peng. Science China Chemistry, 2022, 65, 821-828. 

36. Amorphous Ultra‐Small Fe‐Based Nanocluster Engineered and ICG Loaded Organo‐Mesoporous Silica for GSH Depletion and Photothermal‐Chemodynamic Synergistic Therapy. J. Li, H. Tian, F. Zhu, S. Jiang, M. He, Y. Li, Q. Luo, W. Sun*, X. Liu*, P. Wang*. Adv. Healthcare Mater, 2022, 11, 2201986.

2021

35. Strong π−π Stacking Stabilized Nanophotosensitizers: Improving Tumor Retention for Enhanced Therapy to Large Tumor in Mice. D. Xi, N. Xu, X. Xia, C. Shi, X. Li, D. Wang, S. Long, J. Fan, W. Sun*, X. Peng*. Adv. Mater. 2022, 34, 2102797.

34. A Sequential Dual-Model Strategy Based on Photoactivatable Metallopolymer for On-Demand Release of Photosensitizers and Anticancer Drugs. M. He, G. He, P. Wang, S. Jiang, Z. Jiao, D. Xi, P. Miao, X. Leng, Z. Wei,* Y. Li,* Y. Yang, R. Wang, J. Du, J. Fan, W. Sun,* X. Peng. Adv. Sci. 2021, 8, 2103334. (Front Cover)

33. A Glutathione Activatable Photosensitizer for Combined Photodynamic and Gas Therapy under Red Light Irradiation. R. Wang, X. Xia, Y. Yang, X. Rong, T. Liu, Z. Su, X. Zeng*, J. Du, J. Fan, W. Sun*, X. Peng. Adv. Healthcare Mater. 2021, doi.org/10.1002/adhm.202102017.

32. An Organic Nanotherapeutic Agent Self-Assembled from Cyanine and Cu (II) for Combined Photothermal and Chemodynamic Therapy. X. Li, D. Xi, M. Yang, W. Sun,* X. Peng, and J. Fan*, Adv. Healthcare Mater. 2021, 2101008.  (highlighted by Advanced Science News)

31. Photoresponsive Metallopolymer Nanoparticles for Cancer Theranostics. M. He, F. Chen, D. Shao, P. Weis, Z. Wei, and W. Sun*. Biomaterials 2021, 275, 120915.

30. Coordination and Redox Dual-Responsive Mesoporous Organosilica Nanoparticle Amplify Immunogenic Cell Death for Cancer Chemo-Immunotherapy. W. Sun* Small, 2021, 17, 2100006.

 

29. Red-Light-Responsive Ru Complex Photosensitizer for Lysosome Localization Photodynamic Therapy. G. He, N. Xu, H. Ge, Y. Lu, R. Wang, H. Wang, J. Du, J. Fan, W. Sun*, X. Peng. ACS Applied Materials & Interfaces. 2021, 13,19572-19580.

 

28. A Color Turn-On Fluorescent Probe for Real-Time Detection of Hydrogen Sulfide and Identification of Food Spoilage. P. Xiao, J. Liu, Z. Wang, F. Tao, L. Yang, G. Yuan, W. Sun*, X. Zhang*. Chem. Commun. 2021, 57. 5012-5015.

 

2020

27. Red Light-Triggered Polyethylene Glycol Deshielding from Photolabile Cyanine-Modified Mesoporous Silica Nanoparticles for On-Demand Drug Release. X. Li, W. Sun*, Z, Zhang, Y. Kang, J. Fan*, X. Peng. ACS Applied Bio Materials 2020, 3, 11, 8084-8093.

26. A photosensitizer-inhibitor conjugate for photodynamic therapy with simultaneous inhibition of treatment escape pathways. M. Xiao, J. Fan*, M, Li, F, Xu, X. Zhao, D. Xi, H. Ma, Y. Li, J. Du, W. Sun*, X.Peng. Biomaterials. 2020, 257, 120262.

25. Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem ROS Generation. S. Jiang, M. Xiao, W. Sun*, D. Crespy, V. Mailänder, X. Peng, J. Fan,* K. Landfester* Angew. Chem. Int. Edit. 2020, 59, 2-11. (Hot paper)

 

24.Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H₂O₂. R. Cao , W. Sun*, Z. Zhang, X. Li, J. Du, J. Fan, X. Peng. Chinese Chem. Lett. 2020. 31, 3127-3130.

23. The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo. X. Zhou, M. Xiao, V. Ramu, J. Hilgendorf, X. Li, P. Papadopoulou, M. Siegler, A. Kros, W. Sun*, S. Bonnet*. J. Am. Chem. Soc. 2020, 142, 10383.

 

22. NIR Light‐Driving Barrier‐Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy. D. Xi, M. Xiao, J. Cao, L. Zhao, N. Xu, J. Fan, K. Shao, W. Sun*,  X. Yan, X. Peng*.  Adv. Mater.  2020,  32, 1907855. (ESI highly cited)

21.Sequential Enzyme Activation of a “Pro-staramine”-Based Nanomedicine to Target Tumor Mitochondria. Y. Du, Y. Li, X. Li, C. Jia, L. Wang, Y. Wang, Y. Ding, S. Wang, H. Sun, W. Sun*, J. Tu*, C. Sun*. Adv. Funct. Mater. 2020, 30, 1904697.

2019

20. Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer. W. Sun, M, Li, J. Fan, X. Peng. Accounts. Chem. Res. 2019, 52, 2818.

19. Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti-Metastatic Immunotherapy. Z. Wang, F. Zhang, D. Shao*, Z. Chang, L. Wang, H. Hu, X. Zheng, X. Li, F. Chen, Z. Tu, M. Li, W. Sun*, L. Chen, W. Dong*. Adv. Sci. 2019, 1901690.

 

18. Boron Dipyrromethene Nanophotosensitizers for Anticancer Phototherapies. W. Sun, X. Zhao, J. Fan,* X. Peng. Small 2019, 1804927. (highlighted by Advanced Science News)

17. Oligo Hyaluronan-Coated Silica/Hydroxyapatite Degradable Nanoparticles for Targeted Cancer Treatment. Y. Kang, W. Sun (co-first author), S. Li, M. Li, J. Fan*, J. Du, X.‐J. Liang*, X. Peng. Adv. Sci. 2019, 1900716.

16. "Off-on" Swithing of Intracelluar Singlet Oxygen Release under Biocompatible Conditions. E. Ucar, D. Xi, O. Seven, C. Kaya, X. Peng. W. Sun*, E. Akkaya*. Chem Commun. 2019, 55, 13808-13811.

15. A Novel Mn-Cu Bimetallic Complex for Enhanced Chemodynamic Therapy with Simultaneous Glutathione Depletion. S. Cao*, J. Fan, W. Sun*, F. Li, X. Tai, X. Peng. Chem Commnu. 2019, 55, 12956-12959.

2018

14. Red-Light-Controlled Release of Drug-Ru Complex Conjugates from Metallopolymer Micelles for Phototherapy in Hypoxic Tumor Enviroment. W. Sun, Y. Wen, R. Thiramanas, M. Chen, J. Han, N. Gong, M. Wagner, S. Jiang, M. S. Meijer, S. Bonnet, H.-J.Butt, V. Mailänder,* X.-J. Liang,* S. Wu*. Adv. Funct. Mater. 2018, 1804227.

13. Aminopeptidase N-activated Theranostic Prodrug for NIR Tracking of Local Tumor Chemotherapy. M. Xiao, W. Sun (co-first author), J. Fan,* J. Cao, Y. Li, K. Shao, M. Li, X. Li, Y. Kang, W. Zhang, S. Long, J. Du, X. Peng. Adv. Funct. Mater. 2018, 1805128. (Selected as inside cover)

12. Biodegradable Drug-doped Hydroxyapatite Nanotherapeutic Agent for Targeted Drug Release in Tumors. W. Sun, J. Fan*, S. Wang, Y. Kang, J. Du, X. Peng, ACS Appl. Mater. Inter 2018, 10, 7832-7840.

11. Photoresponsive Ruthenium-Containing Polymers: Potential Polymeric Metallodrugs for Anticancer Phototherapy. W. Sun, X. Zeng, S Wu*. Dalton Trans 2018, 47, 283-286.

10. Electrochemical sensor for determination of ractopamine based on aptamer/octadecanethiol Janus particles. Y. Zhou, Y. Yang, X. Deng, G. Zhang, Y. Zhang, C. Zhang, S. Shuang*, Y. He*, W Sun*. Sensor Actuat B-Chem. 2018, 276, 204–210.

9. Ratiometric Real-Time Monitoring of Hydroxyapatite-DOX Nanotheranostic Agents for On-Demand Tumor Targeted Chemotherapy. K. Yan, W. Sun (co-first author), J. Fan*, Z. Wei, S. Wang, M. Li, Z. Zhang, Y. Xie, J. Du, X. Peng. Mater. Chem. Front. 2018, 2, 1791.

8. Reconfiguring Surface Functions Using Visible-Light Controlled Metal-Ligand Coordination. C. Xie, W. Sun, H. Lu, A. Kretzschmann, J. Liu, M. Wagner, H.-J. Butt, X. Deng*, S. Wu*. Nat. Commun. 2018, 9, 3842.

 

Before 2018

7. An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo. W. Sun, S. Li, B. Häupler, J. Liu, S. Jin, W. Steffen, U. S Schubert, H.-J. Butt, X.-J. Liang,* S. Wu* Adv. Mater. 2017, 29, 1603702. (Selected as inside cover)

6. Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go? W. Sun, R. T., L. D. Slep, X. Zeng, V. Mailänder,* S. Wu*. Chem. Eur. J 2017, 23, 10832-10837.

5. Recent Development of Chemosensors Based on Cyanine Platforms. W.  Sun, S. Guo, C. Hu, J. Fan, X. Peng* Chem. Rev. 2016, 116, 7768-7817. (ESI highly cited)

4. Ruthenium-Containing Block Copolymer Assemblies: Red-Light-Responsive Metallopolymers with Tunable Nanostructures for Enhanced Cellular Uptake and Anticancer Phototherapy. W. Sun, M. Parowatkin, W. Steffen, H.-J. Butt, V. Mailänder, S. Wu*. Adv. Healthcare Mater 2016, 5, 467-473. (Selected as cover picture)

 

3. A Fluorescent Probe for Site I Binding and Sensitive Discrimination of HSA from BSA. J. Fan*, W. Sun, Z. Wang, X. Peng, Y Li*, J. Cao. Chem. Comm. 2014, 50, 9573-9576.

2. A Two-Photon Fluorescent Probe with Near-Infrared Emission for Hydrogen Sulfide Imaging in Biosystems. W. Sun, J. Fan*, C. Hu, J. Cao, H. Zhang, X. Xiong, J. Wang, S. Cui, S. Sun, X. Peng*. Chem. Comm. 2013, 49, 3890-3892. (ESI highly cited)

1. An ICT-based Ratiometric Probe for Hydrazine and Its Application in Live Cells. J. Fan*, W. Sun, M. Hu, J. Cao, G. Cheng, H. Dong, K. Song, Y. Liu, S. Sun, X. Peng*. Chem. Comm. 2012, 48, 8117-8119.