Engin umut Akkaya

基本信息Personal Information

教授

博士生导师

硕士生导师

主要任职:无

性别:男

毕业院校:The Ohio State University

学位:博士

在职信息:在职

所在单位:化工学院

学科:有机化学 精细化工 药物化学

办公地点:大连理工大学西部校区G205

联系方式:13009499815

电子邮箱:

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个人简介Personal Profile

Engin U. Akkaya 教授博士生导师,硕士生导师,土耳其皇家化学学会院士,土耳其科学院成员,辽宁省“兴辽英才计划”创新领军人才 (攀登学者),辽宁省外专百人,大连理工大学星海学者


1991年获得俄亥俄州立大学化学博士学位,随后在俄亥俄州立大学医学院和马里兰大学从事博士后研究工作。1995年在土耳其Middle East Technical University开始了他的独立研究,2003年晋升为全职教授。2007年任土耳其Bilkent University教授。2018年,作为国际化高端科技人才,加入大连理工大学精细化学国家重点实验室与化工学院药学系。曾获得多个国家奖项,包括Parlar基金会,TUBITAK(2009)和TUSEB(2017)的最高荣誉,以及Czarnik,EWHA Lectureship等国际奖。其研究成果多次发表于Nat. Commun.; J. Am. Chem. Soc.Angew. Chem. Int. Ed.; Adv. Funct. Mater等国际著名期刊,并多次被邀请在国际会议上作大会报告。


研究方向:

1. 光动力治疗癌症

2. 分子探针在疾病诊断和治疗中的应用

3. 内过氧类抗癌制剂的设计及抗癌研究

4. 分子逻辑门和分子器件,信息处理性治疗药


代表性成果:

  • Ucar, E.; Xi, D.; Seven, O., Kaya, C.; Peng, X. J., Sun, W., Akkaya, E. U.*“Off-On” Switching of Intracellular Singlet Oxygen Release Under Biocompatible Conditions”, Chem. Commun. 2019,DOI 10.1039/c9cc06231a

  • Turan, I. S., Gunaydin, G., Ayan, S., Akkaya, E. U.*“Molecular Demultiplexer as a Terminator Automaton" Nat. Commun. 2018, 9, 805.

  • Erbas-Cakmak, S., Kolemen, S., Sedgwick, A. C., Gunnlaugsson, T., James, T. D., Yoon, J., Akkaya, E. U.*“Molecular Logic gates: the past, present and future” Chem. Soc. Rev. 2017, 47, 2228.

  • Li, X., Kolemen, S., Yoon, J. and Akkaya, E. U. “Activatable Photosensitizers: Agents for Selective Photodynamic Therapy", Adv. Funct. Mater., 2017, 27, 1604053.

  • Kolemen, S.; Ozdemir, T.; Lee, D. Kim, G. M.; Karatas, T.; Yoon, J.; Akkaya, E. U.*“Remote Controlled Release of Singlet Oxygen by the Plasmonic Heating of  Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy", Angew.  Chem. Int. Ed. 2016, 55, 3606.

  • Turan, I. S.; Yildiz, D.; Turksoy, A.; Gunaydin, G.; Akkaya, E. U.*“A  Bifunctional  Photosensitizer for Enhanced Fractional Photodynamic Therapy:  Singlet Oxygen Generation in the Presence and Absence of Light” Angew. Chem. Int. Ed. 201655, 2875.

  • Kölemen, S.; Işık, M.; Kim, G. M.; Kim, D.; Geng, H.; Buyuktemiz, M; Karatas,T.; Zhang, X.-F.; Dede, Y.; Yoon, J.; Akkaya, E. U.* "Intracellular  Modulation of Excited State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells" Angew. Chem. Int. Ed., 2015, 54, 5340.

  • A. Atılgan, E. T. Eçik, R. Guliyev, T. B. Uyar, S. Erbaş-Çakmak, E.U. Akkaya,* "Near-IR Triggered, Remote-Controlled Release of Metal Ions: A Novel Strategy for Caged Ions," Angew. Chem.Int. Ed., 201453, 10678.

  • Erbas-Cakmak, S.; Akkaya, E.U.*“Cascading of Molecular Logic Gates for Advanced Functions: A Self-Reporting, Activatable Photosensitizer”Angew. Chem. Int. Ed. 2013, 52, 11364. 

  • Erbas-Cakmak, S.; Bozdemir, O.A.;  Cakmak, Y.; Akkaya, E.U.* “Proof of principle for a molecular 1:2 demultiplexer to function as an autonomously switching theranostic device” Chem. Sci. 2013, 4, 858. 

  • Cakmak, Y.; Kolemen, S.; Duman, S.; Dede, Y.; Dolen, Y.; Kilic, B.; Kostereli, Z.; Yildirim, L. T.; Dogan, A. L.; Guc, D.;  Akkaya, E. U.* Designing Excited States: Theory-Guided Access to Efficient Photosensitizers for Photodynamic Action,  Angew. Chem. Int. Ed. 2011, 50, 11937.

  • Bozdemir, O. A.; Erbas-Cakmak, S.; Ekiz, O. O.; Dana, A.; Akkaya, E. U.* Towards Unimolecular Luminescent Solar Concentrators: Bodipy-based Dendritic Energy-Transfer Cascade with Panchromatic Absorption and Monochromatized Emission,  Angew. Chem. Int. Ed. 2011, 50, 10907.

  • Guliyev, R.; Ozturk, S. Kostereli, Z.; Akkaya, E. U.* From Virtual to Physical: Integration of Chemical Logic Gates, Angew. Chem. Int. Ed. 2011, 50, 9826.

  • Kolemen, S.; Bozdemir, O. A.; Cakmak, Y.; Barin, G.; Erten-Ela, S.; Marszalek, M.; Yum, J. H.; Zakeeruddin, S. M.; Nazeeruddin, M. K.; Gratzel, M.; Akkaya, E. U.,* Optimization of distyryl-Bodipy chromophores for efficient panchromatic sensitization in dye sensitized solar cells,  Chem. Sci 2011, 2, 949.

  • Bozdemir, O. A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E. U.* Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Simultaneous Sensing of Multiple Metal Ions.  J. Am. Chem. Soc. 2010, 132, 8029. 

  • Guliyev, R.; Coskun, A.; Akkaya, E. U.* Design Strategies for Ratiometric Chemosensors: Modulation of Excitation Energy Transfer at the Energy Donor Site, J. Am. Chem. Soc. 2009, 131, 9007.

  • Ozlem, S.; Akkaya, E. U.* Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy,  J. Am. Chem. Soc. 2009, 131, 48.

  • Coskun, A; Akkaya, E.U.* Signal Ratio Amplification via Modulation of Resonance Energy Transfer: Proof of Principle in an Emission Ratiometric Hg(II) Sensor,  J. Am. Chem. Soc. 2006, 128, 14474.

  • Coskun, A.; Akkaya, E. U.* Ion Sensing Coupled to Resonance Energy Transfer:  A Highly Selective and Sensitive Ratiometric Fluorescent Chemosensor for Ag(I) by a Modular Approach,  J. Am. Chem. Soc. 2005, 127, 10464.

  • Akkaya, E.U., Huston, M.E.; Czarnik, A.W. Chelation Enhanced Fluorescence of Anthrylazamacrocycle Conjugate Probes in Aqueous Solutions,  J. Am. Chem. Soc., 1990, 112, 3590.

  • Huston, M.E.; Akkaya, E.U.; Czarnik, A.W. Chelation Enhanced Fluorescence Detection of Non-metal Ions, J. Am. Chem. Soc., 1989, 111, 8735.

  • Akkaya, E.U.; Czarnik, A.W. Synthesis and Reactivity of Cobalt(III) Complexes Bearing Primary and Secondary Side Cyclodextrin Binding Sites: A Tale of Two CD’s, J. Am. Chem. Soc., 1988, 110, 8553.


团队及招生情况:

团队依托精细化工国家重点实验室,多项研究处于国际领先地位。组内科研氛围较好,经费充足,配套设施完善,拥有大量先进仪器。团队国际化程度较高,和欧洲,美国,日本以及韩国等多个实验室有着紧密的合作,可为学生提供出国深造的机会。

课题组网站 https://m.x-mol.com/groups/Engin


2020年招收药学 (学硕/3年),药物工程 (学硕/3年),生物与医药 (专硕/3年) 硕士研究生。欢迎药学,制药工程,化学和生物学等相关专业考生报考!此外,课题组常年招收博士后和博士,也欢迎其他有志青年前来交流学习。联系人:王磊老师,leiwang@dlut.edu.cn

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