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窦同意
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讲师(高校) 硕士生导师

性别 : 男

出生年月 : 1987-01-04

毕业院校 : 中国科学院大学

学位 : 博士

在职信息 : 在职

所在单位 : 生命与医药学院

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个人简介

窦同意,男,1987年1月出生,山东济宁人。
 
  主要学历及工作经历:
  2005.09 — 2009.07  天津大学           制药工程          工学学士
  2009.09 — 2016.01  中科院大连化物所   生物化工          工学博士
  2015.03 — 2015.06  芬兰赫尔辛基大学   分子药理          博士交流生
  2015.03 — 2015.06  大连理工大学       生命与医药学院    讲 师
 
  主要研究领域:
  1.生物大数据分析与数据挖掘(生物信息学);
  2.蛋白质结构功能关系研究(生物化学与分子生物学)。
 
  承担项目:
  1. 大连理工大学基本科研业务费 DUT16RC(3)016
  Xyl_S酶的催化机理及其关键催化结构域的鉴定 2016.4-2017.12
  2. 国家自然科学基金-青年基金 24万
  一种新型去糖基酶的催化机理及其关键催化结构域的鉴定 31600641 2017.1-2019.12

  代表性论文:
  [1]Tongyi Dou, Hongwei Luan, Guangbo Ge, Mingming Dong, Hanfa Zou, Yuqi He, Pan Cui, Jiayue Wang, Dacheng Hao, Shilin Yang, Ling Yang*. "Functional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel." Scientific Reports, 5, 13768. (SCI, IF: 5.578)
  [2]Tongyi Dou, Hongwei Luan, Xingbao Liu, Shiyang Li, Xunfu Du and Ling Yang*. "Enzymatic hydrolysis of 7-xylosyltaxanes by an extracellular xylosidase from Cellulosimicrobium cellulans." Biotechnology Letters, 2015, 37(9):1905-1910. (SCI, IF: 1.591)  
  [3]Ziru Dai, Guangbo Ge, Lei Feng, Jing Ning, Lianghai Hu, Qiang Jin, Dandan Wang, Xia Lv, Tongyi Dou, Jingnan Cui, Ling Yang*. "A highly selective ratiometric two-photon fluorescent probe for human cytochrome P450 1A." Journal of the American Chemical Society, 2015, 137(45):14488-95. (SCI, IF: 12.113)
  [4]Xing-Kai Qian, Ping Wang, Yang-Liu Xia, Tongyi Dou, Qiang Jin, Dan-Dan Wang, Da-Cheng Hao, Xiao-Lin Bi, Guang-Bo Ge, Ling Yang, A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B: Chemical, 2016, 231: 615–623
  [5]钱星凯,夏杨柳,窦同意,侯洁,马红,葛广波,秘晓林,杨凌*. 儿茶酚-氧位-甲基转移酶与疾病的关系, 《药学学报》,2016, 51 (4): 543-551. (综合影响因子1.201,复合影响因子1.684,主办方:中国药学会)
  [6]Pan Cui, Tongyi Dou(并列第一), Guangbo Ge. Efficient enzymatic preparation of Esculentoside B following condition optimization by response surface methodology. Journal of Molecular Catalysis B: Enzymatic, Accepted. (SCI, IF: 2.128)  
  [7]Pan Cui, Tongyi Dou(并列第一), Guangbo Ge. Highly selective and efficient biotransformation of linarin to produce tilianin by naringinase. Biotechnology Letters, 2016, 38:1367–1373. (SCI, IF: 1.591)
  [8]Yangliu Xia, Xia Lv, Guiyuan He, Tongyi Dou, Guang-Bo Ge, Ling Yang. In vitro characterization of the glucuronidation pathways of D-luciferin mediated by human UDP-glucuronosyltransferases. Drug Metabolism and Pharmacokinetics, 2017, 32(1): S77
  [9]Wei Lei, Dan-Dan Wang, Tongyi Dou, Jie Hou, Liang Feng, Heng Yin, Qun Luo, Jie Sun, Guang-Bo Ge, Ling Yang. Assessment of the inhibitory effects of pyrethroids against human carboxylesterases. Toxicology and Applied Pharmacology, 2017, 321:48–56
  [10]Zi-Miao Weng, Ping Wang, Guang-Bo Ge, Zi-Ru Dai, Da-Chang Wu, Li-Wei Zou, Tongyi Dou, Jie Hou, Tong-Yan Zhang, Ling Yang. Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase. Food and Chemical Toxicology, Available online 24 March 2017, https://doi.org/10.1016/j.fct.2017.03.042
  [11]Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y. Hong, Tongyi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge, and Ling Yang. A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5, J. Med. Chem., 2017, 60 (9): 3804–3813
  [12]Ping Wang, Yang-Liu Xia, Li-Wei Zou, Xing-Kai Qian, Tongyi Dou, Qiang Jin, Shi-Yang Li, Yang Yu, Dan-Dan Wang, Qun Luo, Guangbo Ge, Ling Yang. An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase. Chemistry, 2017, 23(45):10800-10807.
  [13]Li-Wei Zou, Tongyi Dou (并列第一), Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge, Ling Yang, Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1, Frontiers in Pharmacology, 2017, 8:435.

教育经历

2009.9 - 2016.1 中国科学院大学   生物化工   博士

2005.9 - 2009.6 天津大学   制药工程   学士

2002.9 - 2005.6 嘉祥一中

工作经历

2016.3 - 至今 生命与医药学院

研究方向

蛋白质结构功能关系研究(生物化学与分子生物学)


生物大数据分析与数据挖掘(生物信息学)

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