大连理工大学  登录  English 
窦同意
点赞:

讲师(高校)   硕士生导师

性别: 男

毕业院校: 中国科学院大学

学位: 博士

在职信息:在职

所在单位: 盘锦校区生命与医药学院

电子邮箱:

E-mail :

固定电话 :

手机版

访问量:

开通时间 : ..

最后更新时间: ..

个人简介

窦同意,男,1987年1月出生,山东济宁人。

主要学历及工作经历:
2005.09 — 2009.07 天津大学 制药工程 工学学士
2009.09 — 2016.01 中科院大连化物所 生物化工 工学博士
2015.03 — 2015.06 芬兰赫尔辛基大学 分子药理 博士交流生
2016.03 — 至今 大连理工大学 生命与医药学院 讲 师

主要研究领域:
1.生物大数据分析与数据挖掘(生物信息学);
2.蛋白质结构功能关系研究(生物化学与分子生物学)。

承担项目:
1. 大连理工大学基本科研业务费 DUT16RC(3)016
Xyl_S酶的催化机理及其关键催化结构域的鉴定 2016.4-2017.12
2. 国家自然科学基金-青年基金 24万
一种新型去糖基酶的催化机理及其关键催化结构域的鉴定 31600641 2017.1-2019.12

代表性论文:
[1]Tongyi Dou, Hongwei Luan, Guangbo Ge, Mingming Dong, Hanfa Zou, Yuqi He, Pan Cui, Jiayue Wang, Dacheng Hao, Shilin Yang, Ling Yang*. "Functional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel." Scientific Reports, 5, 13768. (SCI, IF: 5.578)
[2]Tongyi Dou, Hongwei Luan, Xingbao Liu, Shiyang Li, Xunfu Du and Ling Yang*. "Enzymatic hydrolysis of 7-xylosyltaxanes by an extracellular xylosidase from Cellulosimicrobium cellulans." Biotechnology Letters, 2015, 37(9):1905-1910. (SCI, IF: 1.591)
[3]Ziru Dai, Guangbo Ge, Lei Feng, Jing Ning, Lianghai Hu, Qiang Jin, Dandan Wang, Xia Lv, Tongyi Dou, Jingnan Cui, Ling Yang*. "A highly selective ratiometric two-photon fluorescent probe for human cytochrome P450 1A." Journal of the American Chemical Society, 2015, 137(45):14488-95. (SCI, IF: 12.113)
[4]Xing-Kai Qian, Ping Wang, Yang-Liu Xia, Tongyi Dou, Qiang Jin, Dan-Dan Wang, Da-Cheng Hao, Xiao-Lin Bi, Guang-Bo Ge, Ling Yang, A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B: Chemical, 2016, 231: 615–623
[5]钱星凯,夏杨柳,窦同意,侯洁,马红,葛广波,秘晓林,杨凌*. 儿茶酚-氧位-甲基转移酶与疾病的关系, 《药学学报》,2016, 51 (4): 543-551. (综合影响因子1.201,复合影响因子1.684,主办方:中国药学会)
[6]Pan Cui, Tongyi Dou(并列第一), Guangbo Ge. Efficient enzymatic preparation of Esculentoside B following condition optimization by response surface methodology. Journal of Molecular Catalysis B: Enzymatic, Accepted. (SCI, IF: 2.128)
[7]Pan Cui, Tongyi Dou(并列第一), Guangbo Ge. Highly selective and efficient biotransformation of linarin to produce tilianin by naringinase. Biotechnology Letters, 2016, 38:1367–1373. (SCI, IF: 1.591)
[8]Yangliu Xia, Xia Lv, Guiyuan He, Tongyi Dou, Guang-Bo Ge, Ling Yang. In vitro characterization of the glucuronidation pathways of D-luciferin mediated by human UDP-glucuronosyltransferases. Drug Metabolism and Pharmacokinetics, 2017, 32(1): S77
[9]Wei Lei, Dan-Dan Wang, Tongyi Dou, Jie Hou, Liang Feng, Heng Yin, Qun Luo, Jie Sun, Guang-Bo Ge, Ling Yang. Assessment of the inhibitory effects of pyrethroids against human carboxylesterases. Toxicology and Applied Pharmacology, 2017, 321:48–56
[10]Zi-Miao Weng, Ping Wang, Guang-Bo Ge, Zi-Ru Dai, Da-Chang Wu, Li-Wei Zou, Tongyi Dou, Jie Hou, Tong-Yan Zhang, Ling Yang. Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase. Food and Chemical Toxicology, Available online 24 March 2017, https://doi.org/10.1016/j.fct.2017.03.042
[11]Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y. Hong, Tongyi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge, and Ling Yang. A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5, J. Med. Chem., 2017, 60 (9): 3804–3813
[12]Ping Wang, Yang-Liu Xia, Li-Wei Zou, Xing-Kai Qian, Tongyi Dou, Qiang Jin, Shi-Yang Li, Yang Yu, Dan-Dan Wang, Qun Luo, Guangbo Ge, Ling Yang. An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase. Chemistry, 2017, 23(45):10800-10807.
[13]Li-Wei Zou, Tongyi Dou (并列第一), Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge, Ling Yang, Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1, Frontiers in Pharmacology, 2017, 8:435.

教育经历

2009.9 - 2016.1 中国科学院大学   生物化工   博士

2005.9 - 2009.6 天津大学   制药工程   学士

2002.9 - 2005.6 嘉祥一中

工作经历

2016.3 - 至今 生命与医药学院   教师

研究方向

蛋白质结构功能关系研究(生物化学与分子生物学)


生物大数据分析与数据挖掘(生物信息学)

辽ICP备05001357号 地址:中国·辽宁省大连市甘井子区凌工路2号 邮编:116024
版权所有:大连理工大学