现为大连理工大学化工学院药学系副教授，硕士生导师。主要在药物化学及天然药物领域开展研究，致力于针对恶性肿瘤、心血管疾病等开展分子设计合成和构效关系研究、天然活性成分的发现及其结构修饰等。主持完成了辽宁省自然科学基金、国家自然科学基金项目，并作为主要完成人参与完成国家重大新药创制、国家科技支撑计划等多项国家重大项目。在国内外期刊发表研究论文70多篇，授权发明专利5项。为本科生和研究生开设“药物化学”、“药物化学原理”课程，承担3项省级和校级教学研究项目。

研究方向：

      在药物化学和天然药物研究领域，针对抗肿瘤活性小分子和天然分子骨架进行结构修饰、化学合成和作用机制研究。天然光敏剂的结构优化及光动力抗肿瘤研究。

近年代表性论文：

1. Wang, Shisheng, Liu, Liqiang,Guo, Xiuhan,Li, Guangzhe*,Wang, Xu,Dong, Huijuan,Li, Yueqing,Zhao, Weijie.Synthesis of novel natural product-like diaryl acetylenes as hypoxia   inducible factor-1 inhibitors and antiproliferative agents[J],RSC ADVANCES,2019,9(24):13878-13886 

2. Li, Guangzhe,Dong, Huijuan,Ma, Yao,Shao, Kun,Li, Yueqing,Wu, Xiaodan,Wang, Shisheng*,Shao, Yujie,Zhao, Weijie.Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(16):2327-2331

3. Cao, Lei,Wang, Shisheng,Wang, Liu,Guo, Xiuhan,Li, Guangzhe,Zhao, Weijie.Tumor Acidic Microenvironment Targeted Pyropheophorbide a Dimer, an Alternative Strategy for Simultaneous Tumor Fluorescence Imaging and PDT Treatment[J],MACROHETEROCYCLES,2019,12(2):187-192 

4. Song, Yanlin,Wang, Shisheng*,Hu, Min,Tang, Zeyao*,Gao, Lei,Tang, Zhongyuan,Li, Hailong,Sun, Bin,Chu, Peng,Qaed, Eskandar,Ma, Xiaodong,Peng, Jinyong.Anticancer effect of SZC015 on pancreatic cancer via   mitochondria-dependent apoptosis and the constitutive suppression of   activated nuclear factor B and STAT3 in vitro and in vivo[J],JOURNAL OF CELLULAR PHYSIOLOGY,2019,234(1):777-788 

5. Guo, Xiuhan,Li, Yueqing,Wang, Shisheng*,Wang, Liu,Cai, Rui,Li, Guangzhe,Zhao, Weijie.Evaluation for in vitro Photodynamic Activity of Chlorin e(6)-Artesunate Conjugates by Irradiation with Different Wavelengths of Light Source[J], MACROHETEROCYCLES,2018,11(4):378-382 

6. Guo, Xiuhan,Wang, Liu,Wang, Shisheng*,Li, Yueqing,Cao, Lei,Cai, Rui,Zhao, Weijie.Synergistic antiproliferative effect of chemo-phototherapy: Synthesis and photodynamic activity evaluation of novel Chlorin e6-artesunate conjugates as antiproliferative agents[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(19):4548-4551 

7. Zhang, Ge,Guo, Xiu-Han,Wang, Shi-Sheng*,Li, Yue-Qing,Li, Guang-Zhe,Zhao, Wei-Jie.Screening and identification of natural ligands of tyrosinase from   Pueraria lobata Ohwi by a combination of ultrafiltration and LC-MS[J],ANALYTICAL METHODS,2017,9(33):4858-4862 

8. Song, Yanlin,Ma, Xiaodong,Zhang, Jianbin,Wang, Shisheng*,Tang, Zeyao*,Kong, Lingqi,Sun, Bin,Gao, Lei,Chu, Peng,Ahsan, Anil,Qaed, Eskandar,Lin, Yuan,Peng, Jinyong.Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells[J],CELL BIOLOGY INTERNATIONAL,2017,41(12):1367-1378

9. Sun, Bin,Song, Zhicheng,Wang, Shisheng*,Tang, Zeyao*,Gao, Lei,Ahsan, Anil,Chu, Peng,Song, Yanlin,Li, Hailong,Zhang, Zonghui,Lin, Yuan,Peng, Jinyong.Anticancer effect of SZC015 on lung cancer cells through ROS-dependent   apoptosis and autophagy induction mechanisms in vitro[J],INTERNATIONAL IMMUNOPHARMACOLOGY,2016,40:400-409 

10. Guo, Xiuhan,Wang, Shisheng*,Li, Yueqing,Song, Bo,Zhao, Weijie.Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(19):4078-4081 

授权发明专利：

1. 一类含苯并咪唑基团的二芳基酰胺类化合物及其合成及应用 

2. 计明胺类甾体生物碱衍生物、其制备及在抗血栓药物中的应用 

3. 亲水性长波长二氢卟吩类光、声敏剂及其制备方法与应用 

4. 一类生物亲和探针分子及其制备方法与应用 

5. 亲水性长波长二氢卟吩类光、声敏剂及其制备方法与应用 

招生专业：

药学，药物工程，生物与医药