Personal InformationMore >>
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Doctor Bo Liu is currently the dean, professor and doctoral supervisor of the school of Biomedical Engineering, Dalian University of Technology, and the council member of the National Intelligent Sensor Innovation Alliance. He has the educational background of biology, medical science,engineering,and also the postdoctoral experience in UIUC. He has been engaged in the fundamental and applied research in Biomedical Engineering for more than 20 years，and the main work combines the principles and methods of biophysics, medical science, cell biology, tissue engineering, genetic engineering and others. An in vitro vascular organ culture system has been established which integrated pressure, blood flow, temperature and other biological probes as well as motor valves to realize dynamic detection and automatic adjustment of organ culture in vitro. A new research direction in the field of biophysics, namely the effect of pulsatile frequency of mechanical stress on cell function, has been put forward firstly. The further development of this research direction is expected to solve some important basic mechanism problems in cardiovascular disease, sports medicine, oncology, aerospace medicine and so on. One paper was published on Biophysical Journal, whose reviewers evaluated it as a landmark study of the mechanism of cellular strain response. His team also integrated the FRET technology, developed by Nobel Prize owner Professor Roger Y. Tsien based on fluorescent protein，into the field of biomedical engineering. New biosensors were developed to realize the real-time detection of protein activity and stress transmission in living cells under mechanical stress, and the machanotransduction was explored with mechanobiology, molecular biology, image processing and other methods. He has presided over 4 projects of the National Natural Science Foundation of China(NSFC) (No. 31670867, No. 31000060, No. 30570459, No. 10972139), participated in 2 key projects (No. 10732070, No. 10132020) and 12 projects from NSFC. He also presided over two research and development projects from enterprises to develop microfluidic chips for bladder cancer detection through non-invasive biological detection technology. Accumulatively, more than 80 articles have been published, including iScience (Cell Press), Biomolecules, Scientific Reports (Nature Press), Cardiovascular Research (Top in Orthopedics), Journal of Royal Society Interface, Journal of Orthopaedic Research (Top in Orthopedics). 11 invention patents have been applied, and one of them has been transferred to enterprises. At present, the team are focusing to the design, fabrication and application of new fluorescent protein FRET probes, as well as the dynamic detection of live protein activity on microfluidic chips.