Bo Liu

Personal Information

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Professor   Supervisor of Doctorate Candidates   Supervisor of Master's Candidates  

Personal Profile

Doctor Bo Liu is currently the dean, professor and doctoral supervisor of the school of Biomedical Engineering, Dalian University of Technology, and the council member of the National Intelligent Sensor Innovation Alliance. He has the educational background of biology, medical science,engineering,and also the postdoctoral experience in UIUC. He has been engaged in the fundamental and applied research in Biomedical Engineering for more than 20 years,and the main work combines the principles and methods of biophysics, medical science, cell biology, tissue engineering, genetic engineering and others. An in vitro vascular organ culture system has been established which integrated pressure, blood flow, temperature and other biological probes as well as motor valves to realize dynamic detection and automatic adjustment of organ culture in vitro. A new research direction in the field of biophysics, namely the effect of pulsatile frequency of mechanical stress on cell function, has been put forward firstly. The further development of this research direction is expected to solve some important basic mechanism problems in cardiovascular disease, sports medicine, oncology, aerospace medicine and so on. One paper was published on Biophysical Journal, whose reviewers evaluated it as a landmark study of the mechanism of cellular strain response. His team also integrated the FRET technology, developed by Nobel Prize owner Professor Roger Y. Tsien based on fluorescent protein,into the field of biomedical engineering. New biosensors were developed to realize the real-time detection of protein activity and stress transmission in living cells under mechanical stress, and the machanotransduction was explored with mechanobiology, molecular biology, image processing and other methods. He has presided over 4 projects of the National Natural Science Foundation of China(NSFC) (No. 31670867, No. 31000060, No. 30570459, No. 10972139), participated in 2 key projects (No. 10732070, No. 10132020) and 12 projects from NSFC. He also presided over two research and development projects from enterprises to develop microfluidic chips for bladder cancer detection through non-invasive biological detection technology. Accumulatively, more than 80 articles have been published, including iScience (Cell Press), Biomolecules, Scientific Reports (Nature Press), Cardiovascular Research (Top in Orthopedics), Journal of Royal Society Interface, Journal of Orthopaedic Research (Top in Orthopedics). 11 invention patents have been applied, and one of them has been transferred to enterprises. At present, the team are focusing to the design, fabrication and application of new fluorescent protein FRET probes, as well as the dynamic detection of live protein activity on microfluidic chips.

Education BackgroundMore>>

2005.4 2007.12

  • 上海交通大学
  • 生物医学工程
  • Doctoral Degree

1998.9 2001.6

  • 第二军医大学
  • 解剖与组织胚胎学
  • Master's Degree

1991.9 1995.6

  • 华东师范大学
  • 生物学
  • Bachelor's Degree

Work ExperienceMore>>

2012.4 Now
  • 大连理工大学
  • 教授
1995.7 2004.8
  • 第二军医大学
  • 助教,讲师
2004.9 2012.3
  • 上海交通大学
  • 助研,副研

Social Affiliations

Research Focus

  • 微流控临床检测芯片:基于微流控技术研发新型芯片,实现临床疾病的早期快速低成本检测。
  • FRET生物探针设计与应用:基于荧光蛋白技术设计可以在活细胞检测蛋白活性的探针结构,在相应的DNA层面上通过亚克隆构建探针,然后转入活细胞自行表达出探针蛋白,在活细胞上验证探针功能。
  • 细胞力学生物学:研究各种力学状态下,细胞通过何种信号途径,将物理的李学新号转化为细胞内生物化学信号,并调控细胞极性变化与定向迁移。