Chen Qixian   

特聘研究员

Honors and Titles : MEXT Scholarship, 2008 - 2010 ;
MEXT Scholarship, 2010 - 2013 ;
Chinese Government Award for Outstanding Self-financed Student Abroad, Certificate No: 2012-390, 2012;
Dean Award for the Excellence in the University of Tokyo, 2013.

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Language:English

Personal Information

Qixian Chen is thrilled to serve as principal investigator (professor) in School of Life Science and Biotechnology, Dalian University of Technology, in attempt to challenge the cutting-edge technology of nanomedicine.

Education Background
Oct 2010 – Sep 2013
The University of Tokyo
PhD, Materials Engineering
Tokyo, Japan

Oct 2008 – Sep 2010
The University of Tokyo
Master Degree of Engineering, Materials Engineering
Tokyo, Japan

Sep 2003 – Jun 2008
Dalian University of Technology
Bachelor of Science & Art, Materials Science and Technology & English
Dalian, China


Research Experience
Apr 2015 – Mar 2017
Joint Research Scientist
i) Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA, USA; ii) Massachusetts Institute of Technology, Koch Institute of Integrative Cancer Research Cambridge, Cambridge, MA, USA; iii) Massachusetts General Hospital, Boston, MA, USA

Nov 2013 – Mar 2015
Project Researcher
The University of Tokyo, Faculty & Graduate School of Engineering,
Tokyo, Japan

Publication
1. Q. Chen, K. Osada*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka*, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors, Biomaterials, 33, 18, 4722, 2012. (影响因子:8.402)
2. Q. Chen, K. Osada*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka*, Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials, 113, 253, 2016. (影响因子:8.402)
3. Q. Chen#,*, R. Qi#, X. Chen, H. Xiao, W. Dong*, Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression. ACS Applied Materials & Interfaces, 8, 24404, 2016. (影响因子:7.504)
4. Q. Chen#,*, R. Qi, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong*, A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors. Molecular Therapy, 25(1), 92, 2017. (影响因子:6.688)
5. Q. Chen, K. Osada*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka*, Tadpole-shaped gene carrier with distinct phase segregation in ternary polymeric micelle, Soft Matter, 11, 14, 2718, 2015. (影响因子:3.889)
6. Z. Ge#, Q. Chen#, K. Osada*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka*, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors, Biomaterials, 35, 10, 3416, 2014. (影响因子:8.402)
7. J. Li#, Q. Chen#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka*, and Z. Ge*, Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery, Journal of Controlled Release, 209, 77, 2015. (影响因子:7.786)
8. X. Han#, Q. Chen#, H. Lu, J. Ma, H. Gao*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative. ACS Applied Materials & Interfaces, 7, 28494, 2015. (影响因子:7.504)
9. X. Han#, Q. Chen#, W. Lu, G. Wu, J. Ma, H. Gao*, Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form. Chemical Communications, 52, 3907, 2016. (影响因子:6.319)
10. T. Wang#, Q. Chen#, W. Li, G. Wu, J. Ma, H. Gao*, Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing. Bioconjugate Chemistry, 27, 1949, 2016. (影响因子:4.818)
11. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen*, H. Gao, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Applied Materials & Interfaces, 7, 23760, 2015. (影响因子:7.504)
12. Y. Li, J. Li, B. Chen, Q. Chen*, G. Zhang, Z. Ge*, S. Liu, Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection, Biomacromolecules, 15, 8, 2914, 2014. (影响因子:5.246)
13. J. Li, Y. Han, Q. Chen*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge*, S. Liu, Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin, Journal of Materials Chemistry B, 2, 13, 1813, 2014. (影响因子:4.453)
14. Y. Wu, Q. Chen*, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016. (影响因子:4.453)
15. X. Yang, Q. Chen*, J. Yang, S. Wu,  J. Liu,  Z. Li, D. Liu,  X. Chen, Y. Qiu*, Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness. ACS Applied Materials & Interfaces, 2017. (影响因子:7.504)
16. Z. Jiang, Q. Chen*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao*, Polyplex Micelle with pH-Responsive PEG Detachment and Functional Tetraphenylene Incorporation to Promote Systemic Gene Expression. Bioconjugate Chemistry, 28 (11), 2849–2858, 2017.(影响因子:4.818)
17. J. Yang , R. Liang, Y. Chen*,  C. Zhang,  R. Zhang, X. Wang, R. Kang, Q. Chen*, Using a Self-Assemblable Nucleating Agent to Tailor Crystallization Behavior, Crystal Morphology, Polymorphic Crystalline Structure, and Biodegradability of Poly(1,4-butylene adipate). Industrial & Engineering Chemistry Research 56(28), 7910-7919, 2017.(影响因子:2.843)
18. Z. Li, Y. Wi, Z. Liu, T. Hao, L. Qiu, X. Sun, M. Qiao, H. Hu, X. Zhao, Q. Chen*, D. Chen*, Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-Vitamin E Succinate for reversing multidrug resistance of doxorubicin, ACS Applied Materials & Interfaces, 2017. (影响因子:7.504)
19. S. Chen#, Q. Chen#, J. Ma, H. Gao*, Biodegradable Synthetic Antimicrobial with Aggregation Induced Emissive Luminogens for Temporal Antibacterial Activity and Facile Bacteria Detection, Advanced Functional Materials, 2017. (影响因子:12.124)
20. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka*, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size, Nature Nanotechnology, 6, 12, 815, 2011.(影响因子:38.986)
21. K. Itaka, S. Uchida*, Q. Chen, T. Ishii, K. Osada, K. Kataoka*, Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses, Human Gene Therapy, 10, 22, 88, 2011. (影响因子:3.380)
22. S. Uchida, K. Itaka*, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka*, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses, Molecular Therapy, 20, 6, 1196, 2012.(影响因子:6.688)
23. F. Pittella, K. Miyata*, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka*, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles, Journal of Controlled Release, 161, 3, 868, 2012. (影响因子:7.786)
24. T. A. Tockary, K. Osada*, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka*, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers, Macromolecules, 46, 16, 6585, 2013. (影响因子:5.835)
25. A. Dirisala, K. Osada*, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka*, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors, Biomaterials, 35, 20, 5359, 2014. (影响因子:8.402)
26. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka*, Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity, Chemical Communications, 51, 15, 3158, 2015. (影响因子:6.319)
27. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka*, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression, Biomacromolecules, 16, 2664, 2015. (影响因子:5.583)
28 Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang*, Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate. European Polymer Journal, 72, 222, 2015. (影响因子:3.531)
29. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery, Chemical Communications, 51, 4715, 2015. (影响因子:6.567)
30. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka*, Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 12, 1193, 2016. (影响因子:8.643)
31. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge*, Self-sufficing H2O2-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy. Journal of Controlled Release, 225, 64, 2016. (影响因子:7.786)
32. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen*, Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy. Biomaterials, 100, 118, 2016. (影响因子:8.402)
33. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016. (影响因子:4.453)
34. X. Yang, W. Li, Q. Chen, M. Li, R. Qi*, Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment. Nanomedicine: nanotechnology, Biology and Medicine, 13, 287, 2016. (影响因子:5.720)
35. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka*, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression. Biomacromolecules, 18, 36, 2017. (影响因子:5.246)
36.  H. V.-T.  Nguyen, Chen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D.  Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson*, Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors. ACS Central Science 3, 800-811, 2017. (影响因子: 7.939)
37. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems. Journal of Materials Chemistry B, 5, 8322, 2017. (影响因子:4.453)
38. Hui Wu, Xi Yang, Ran Wang, Qixian Chen, Ruogu Qi, Xing Huang, Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance. Materials Science & Engineering C, 2017. (影响因子:4.164)
39. Ruogu Qi, Yongheng Wang, Peter Bruno, Haihua Xiao, Yingjie Yu, Ting Li, Samuel Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pépin, Michael Hemann, Michael Birrer,  Paiman Ghoroghchian*. Nanoparticle-conjugates of a Highly Potent Toxin Enhance Safety and Circumvent Platinum Resistance in Ovarian Cancer, Nature Communications, 2017. (影响因子:12.124)
40. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye*, Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating. Energy Storage Materials, 2017.(即时影响因子:12.38)
41. Dee Liu, Qixian Chen, Jianbiao Ma, Hui Gao*, Thermo-responsive Organogel as Transdermal Drug Delivery system. Polymer Chemistry, 2017.(影响因子:5.375)
42. R. Qi, S. Le, Q. Yang, Q. Chen*, Nanoparticle mediated delivery of satraplatin to overcome cisplatin drug resistance, ACS Applied Nano Materials, 2017.
43. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao*, Dual functionalized amino poly (glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. Journal of Materials Chemistry B, 3, 6911, 2015. (影响因子:4.453)
44. S. Uchida, K. Itaka*, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka*, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity, Journal of Controlled Release, 155, 2, 296, 2011. (影响因子:7.786)
45. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang*, Fabrication and physical properties of poly(Epsilon-caprolactone)/modified graphene nanocomposite. Macromolecular Materials and Engineering, 302(3), 2016. (影响因子:2.863)
46. Q. Chen,Nature Communications, 2018. (影响因子:12.124)
47.  R. Kong, L. Xue, J. Tang, Q.n Chen, Y. Chen, R. Liang, X. Wang, L. Li, J. Yang*, Polymorphism, thermal stability and biodegradation of poly(1,4-butylene adipate) manipulated by a benzene-1,3,5-tricarboxamide-based nucleating agent, Polymer Testing, 2018.

Education Background

  • 2010.10-2013.9  

    The University of Tokyo       ID205224       Doctoral Degree

  • 2008.10-2010.9  

    The University of Tokyo       ID205224       Master's Degree

  • 2007.9-2008.6  

    Dalian University of Technology       ID603650       Bachelor's Degree

  • 2003.9-2007.6  

    Dalian University of Technology       ID205224       Bachelor's Degree

Work Experience

  • 2017.7-Now

    Dalian University of Technology      School of Life Science and Biotechnology      Principal Investigator      Active

  • 2015.4-2017.3

    Masschusetts Institute of Technology      Department of Chemistry&Koch Institute for Integrative Cancer Research      Postdoctoral Associate      Completed

  • 2013.11-2015.3

    The University of Tokyo      School of Engineering      Project Reseacher      Completed

Research Group

Team Name :

Nanomedicine

Team Introduction :

GO BIG or Go HOME! Progress Everyday!
Address: No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024
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