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    陈麒先

    • 特聘研究员    
    • 性别:男
    • 毕业院校:东京大学
    • 学位:博士
    • 在职信息:在职
    • 所在单位:生命科学与技术学院
    • 学科:生物医学工程 药物工程 高分子材料
    • 办公地点:生物科学与技术楼205室(办公室),化学楼107室(实验室)
    • 联系方式:15734185256(手机)
    • 电子邮箱:

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    个人简介

    陈麒先,大连理工大学生命与科学技术学院特聘研究员,大连理工大学"星海青年千人"入选者。师从美国工程院院士、日本东京大学 Prof. Kazunori Kataoka(片冈一则教授),求学期间在国际著名学术期刊 Nature Nanotechnology、Nature Communications、ACS Central Science、Chemistry of Materials、Biomaterials、Small、Journal of Controlled Release、Molecular Therapy 等发表论文50余篇,其中20余篇为第一作者或通讯作者,累积影响因子超过400分,被他人引用近2000次。2013年起担任美国麻省理工学院(MIT)化学系(Prof. Jeremiah A. Johnson 研究室)博士后研究员,致力于化学、生物、医学交叉学科研究工作,同时担任麻省理工学院癌症研究中心(MIT Koch Institute)、哈佛大学附属麻省总医院(MGH)癌症中心研究员,从事临床转化工作。陈麒先博士在纳米医学领域,尤其在发展基因和药物载体系统治疗顽固性癌症以及中枢神经疾病领域取得了突出进展。

    第一作者或通讯作者:
    1. S. Chen#
    Q. Chen#, Q. Li, J. An, P. Sun, J. Ma, H. Gao*, Biodegradable synthetic antimicrobial with aggregation induced emissive luminogens for temporal antibacterial activity and facile bacteria detection. Chemistry of Materials, 30, 1782, 2018. (影响因子:9.890) 
    2. 
    Q. Chen, K. Osada*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka*, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials, 33, 18, 4722, 2012.(影响因子:8.806)
    3. 
    Q. Chen, K. Osada*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka*, Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials, 113, 253, 2016.(影响因子:8.806)
    4. Z. Ge#
    Q. Chen#, K. Osada*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka*, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials, 35, 10, 3416, 2014.(影响因子:8.806)
    5. 
    Q. Chen#,*, R. Qi#, X. Chen, H. Xiao, W. Dong*, Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression. ACS Applied Materials & Interfaces, 8, 24404, 2016.(影响因子:8.097)
    6. Q. Chen#,*, R. Qi#, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong*, A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors. Molecular Therapy, 25(1), 92, 2017.(影响因子:7.008)
    7. J. Li#Q. Chen#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka*, Z. Ge*, Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery. Journal of Controlled Release, 209, 77, 2015.(影响因子:7.877)
    8. X. Han#Q. Chen#, H. Lu, J. Ma, H. Gao*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative. ACS Applied Materials & Interfaces, 7, 28494, 2015.(影响因子:8.097
    9. X. Han#Q. Chen#, W. Lu, G. Wu, J. Ma, H. Gao*, Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form. Chemical Communications, 52, 3907, 2016.(影响因子:6.290)
    10. T. Wang#Q. Chen#, W. Li, G. Wu, J. Ma, H. Gao*, Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing. Bioconjugate Chemistry, 27, 1949, 2016.(影响因子:4.485)
    11. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen*, H. Gao*, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Applied Materials & Interfaces, 7, 23760, 2015.(影响因子:8.097
    12. Y. Li, J. Li, B. Chen, Q. Chen*, G. Zhang, Z. Ge*, S. Liu, Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection. Biomacromolecules, 15, 8, 2914, 2014.(影响因子:5.738)
    13. J. Li, Y. Han, Q. Chen*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge*, S. Liu, Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin. Journal of Materials Chemistry B, 2, 13, 1813, 2014. (影响因子:4.776)
    14. D. Liu#Q. Chen#, Y. Long, J. Ma, H. Gao*, A thermo-responsive polyurethane organogel for norfloxacin delivery. Polymer Chemistry, 9, 228, 2018.(影响因子:4.927)

    15. X. Yang, Q. Chen*, J. Yang, S. Wu,  J. Liu,  Z. Li, D. Liu,  X. Chen, Y. Qiu*, Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness. ACS Applied Materials & Interfaces, 9(50), 44045-44052, 2017.(影响因子:8.097
    16. Z. Jiang, Q. Chen*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao*, Polyplex micelle with pH-responsive PEG detachment and functional tetraphenylene incorporation to promote systemic gene expression. Bioconjugate Chemistry, 28 (11), 2849-2858, 2017.(影响因子:4.485
    17. J. Yang, R. Liang, Y. Chen*,  C. Zhang,  R. Zhang, X. Wang, R. Kang, Q. Chen*, Using a self-assemblable nucleating agent to tailor crystallization behavior, crystal morphology, polymorphic crystalline structure, and biodegradability of poly(1,4-butylene adipate). Industrial & Engineering Chemistry Research, 56(28), 7910-7919, 2017.(影响因子:3.141)
    18. J. Yang*, X. Wang, R.Liang, R. Kong, Y. Sun, J. Tang, L. Li, L. Xue, Q. Chen*, Polymorphism, thermal stability and biodegradation of poly(1,4-butylene adipate) manipulated by a benzene-1,3,5-tricarboxamide-based nucleating agent. Journal of Materials Science, 53, 10569-10581,  2018. (影响因子: 2.993)
    19. Q. Chen, K. Osada*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka*, A tadpole-shaped gene carrier with distinct phase segregation in ternary polymeric micelle. Soft Matter, 11, 14, 2718, 2015.(影响因子:3.709)
    20. X. Chen*, H. Gu, J. Yang, S. Wu, J. Liu, X. Yang, Q. Chen*, Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles. ACS Applied Materials & Interfaces, 9, 8455-8459, 2017.(影响因子:8.097

    21. Y. Huang#, Q. Chen#, H. Lu, J. An, H. Zhu, X. Yan, W. Li, H. Gao*, Near-infrared AIEgen-functionalized and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert spatiotemporal responsibility for promoted gene delivery. Journal of Materials Chemistry B, 2018. (影响因子:4.776)

    22. J. Xia, J. Wang, X. Wang, M. Qian, L. Zhang, Q. Chen*, Ultrasound-responsive nanoparticulate for selective amplification of chemotherapeutic potency for ablation of solid tumors. Bioconjugate Chemistry, 29(10), 3467-3475, 2018. (影响因子:4.485)

    23. Circumvent biological barriers by a synthetic gene transporter with dual endogenous and exogenous responsive functionalities. Nanoscale, 2018. 

    24. S. Chen #, Q. Chen #, S. Dong, J. Ma, Y. Yang, L. Chen *, H. Gao *, Polymerbrush decorated MOF nanoparticles loaded with AIEgens, anticancer drug, and supramolecular glue for regulating and in situ observing DOX release. Macromolecular Bioscience, 2018. (影响因子:3.392)

    25. P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu,  Q. Chen*, Transcellular delivery of messenger RNA payloads by cationic supramolecular MOF platform. Chemical Communications, 54, 11304-11307, 2018. (影响因子:6.290)

    26. Poly(lactobionamidoethyl methacrylate)-based copolymer with ultrasound-labile motif in manufacture of drug delivery nanoparticulates for augmented efficacy to hepatocellular carcinoma. Journal of Materials Chemistry B, 2018. (Under review)

    27. Intracellular superoxide dismutase delivery vehicles constructed from dendritic MOF and charge reversible protein derivatives. Chemical Science, 2018. (Under review)

    28. Infrared photodynamic AIEgens at 980 nm based on photon up-conversion and fluorescence resonance energy transfer.  Chemical Communications, 2018.  (Under review)


    其他共同作者:
    29. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka*, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nature Nanotechnology, 6, 12, 815, 2011.(影响因子:37.490)

    30. Z. Li, Q. Chen, Y. Qi, Z. Liu, T. Hao, X. Sun, M. Qiao, X. Ma, T. Xu, X. Zhao, C. Yang, D. Chen*, Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-vitamin E Succinate for reversing tumor multidrug resistance. Biomacromolecules, 19, 2595-2609, 2018.(影响因子:5.583)

    31. S. Uchida, K. Itaka*Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka*, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Molecular Therapy, 20, 6, 1196, 2012.(影响因子:7.008
    32. F. Pittella, K. Miyata*, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka*, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. Journal of Controlled Release, 161, 3, 868, 2012.(影响因子:7.877
    33. T. A. Tockary, K. Osada*Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka*, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules, 46, 16, 6585, 2013.(影响因子:5.940)
    34. A. Dirisala, K. Osada*Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka*, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials, 35, 20, 5359, 2014.(影响因子:8.806
    35. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka*, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression. Biomacromolecules, 16, 2664, 2015.(影响因子:5.738
    36. Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang*, Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate. European Polymer Journal, 72, 222, 2015.(影响因子:3.741)
    37. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery. Chemical Communications, 51, 4715, 2015.(影响因子:6.290
    38. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka*, Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 12, 1193, 2016.(影响因子:9.598)
    39. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge*, Self-sufficing H2O2-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy. Journal of Controlled Release, 225, 64, 2016.(影响因子:7.877
    40. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen*, Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy. Biomaterials, 100, 118, 2016.(影响因子:8.806
    41. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016.(影响因子:4.776
    42. X. Yang, W. Li, Q. Chen, M. Li, R. Qi*, Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment. Nanomedicine: Nanotechnology, Biology and Medicine, 13, 287, 2016.(影响因子:6.50)
    43. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka*, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression. Biomacromolecules, 18, 36, 2017.(影响因子:5.738
    44. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems. Journal of Materials Chemistry B, 5, 8322, 2017.(影响因子:4.776
    45. R. Qi, Y. Wang, P. Bruno, H. Xiao, Y. Yu, T. Li, S. Lauffer, W. Wei, Q. Chen, X. Kang, H. Song, X. Yang, X. Huang, A. Detappe, U. Matulonis, D. Pépin, M. Hemann, M. Birrer,  P. Ghoroghchian*. Nanoparticle-conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer. Nature Communications, 8(1), 2166, 2017. (影响因子:12.353)
    46. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka*, Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity. Chemical Communications, 51, 15, 3158, 2015.(影响因子:6.290

    47. X. Yang, Y. Yu, X. Huang, Q. Chen, H. Wu, R. Wang, R. Qi, R. Miao, Y. Qiu*, Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance. Materials Science & Engineering C, 2018. (影响因子:5.080)
    48. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao*, Dual functionalized amino poly (glycerol methacrylate) with guanidine and schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. Journal of Materials Chemistry B, 3, 6911, 2015.(影响因子:4.776
    49. S. Uchida, K. Itaka*Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka*, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. Journal of Controlled Release, 155, 2, 296, 2011.(影响因子:7.786)
    50. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang*, Fabrication and physical properties of poly(epsilon-caprolactone)/modified graphene nanocomposite. Macromolecular Materials and Engineering, 302(3), 2016.(影响因子:2.690)
    51. Z. Lu, S. Zhang, J. Sheng, P. Gao, Q. Chen, Z. Peng, S. Wu*, J. Ye*, Rapid crystallization of amorphous silicon films utilizing Ar-H2 mesoplasma, annealing. Journal of Crystal Growth, 486, 142, 2018.(影响因子:1.742)

    52. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye*, Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating. Energy Storage Materials, 11, 47-56, 2018.(即时影响因子:12.38)

    53. H. V.-T.  Nguyen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D.  Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson*, Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors. ACS Central Science 3, 800-811, 2017.(影响因子: 11.228)

    54. K. Itaka, S. Uchida*Q. Chen, T. Ishii, K. Osada, K. Kataoka*, Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses. Human Gene Therapy, 10, 22, 88, 2011.(影响因子:4.241)

    55. Hyaluronic acid/PEGlated amphiphilic nanoparticulates for pursuit of selective intracellular doxorubicin release. Journal of Materials Chemistry B, 2018.(影响因子:4.776)

    56.  Efficient and controllable growth of vertically oriented graphene nanosheets by mesoplasma chemical vapor deposition. Carbon, 2018. 


    专利(发明专利):
    【01】US9314529B2 Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and the method for nucleic acid delivery(美国专利)
    【02】DK2591792T3 Sammensætning til nukleinsyre-afgivelse, bæremiddel-sammensætning, pharmaceutisk sammensætning med sammensætning til nukleinsyre-afgivelse eller bæremiddel-sammensætning og fremgangsmåde til nukleinsyre-afgivelse(丹麦专利)
    【03】JP5826174B2 核酸送達用組 成物及び担体組成物、それを用いた医薬組成物、並びに核酸送達方法(日本专利)
    【04】EP2591792B1 Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid (欧盟专利)
    【05】CN102971002A 核酸递送用组 合物及载体组合物、使用其的药物组合物以及核酸递送方法(中国专利)
    【06】CA2804815C Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and method for nucleic acid delivery(加拿大专利)
    【07】US62404098 Bottlebrush copolymers and uses thereof(美国专利)
    【08】CN201610334823.7 纳米药物存储器、其制备方法及其应用(中国专利)
    【09】CN207107734 一种复合蛋白质脂质体纳米制剂(中国专利)
    【10】CN201710561380 一种金属有机骨架聚阳离子衍生物及其制备方法和应用(中国专利)


    教育经历

    2003.9 -- 2007.6
    大连理工大学       材料物理       学士

    2010.10 -- 2013.9
    东京大学       材料工学       博士

    2008.10 -- 2010.9
    东京大学       材料工学       硕士

    2007.9 -- 2008.6
    大连理工大学       材料物理       学士

    工作经历

    2017.7 -- 至今

    大连理工大学化工与环境生命学部

    2015.4 -- 2017.3

    麻省理工学院

    2013.11 -- 2015.3

    东京大学

    社会兼职

  • 2015.7 -- 至今

    国际期刊编委:Advances in Pharmacognosy and Phytomedicine

  • 2012.7 -- 至今

    国际期刊编委:Advances in Biology, Biotechnology and Genetics

  • 研究方向

  • ^-^基因药物递送系统的开发和应用:通过设计合成安全高效的基因递送功能分子,构建了包载DNA的纳米输运载体,通过对DNA凝缩理论的系统和深入研究,实现了对包载凝缩DNA纳米运载体的尺寸、形状和形状的精准控制,在病灶部位实现了持续高效的表达药用蛋白质。

  • ^-^克服血脑屏障的高渗透药物递送系统:针对脑退化疾病(阿尔海默病、帕金森病等)开发高效通透血脑屏障(BBB)的药物递送系统,实现靶向输送药物到神经元细胞或胶质细胞。

  • ^-^肿瘤高靶向性、高渗透性纳米药物递送系统的研究:构建多功能、环境响应型、靶向性、智能化的聚合物纳米药物递送系统,通过对聚合物高分子的分子结构及其组装的纳米精准控制,实现对各类恶性肿瘤实现高效的治疗效果。

  • ^-^具有响应性,功能性的生物水凝胶:针对人类重大慢性病(如眼科疾病:白内障,葡萄糖膜炎等疾病)以及人类重大疾病(原发或复发性恶性癌症等)开发的的高度可控的模块化介入型的纳米药物缓释体技术。

  • 团队成员

    纳米医学