• 其他栏目

    陈麒先

    • 曾获荣誉 : 日本文部省奖学金(MEXT), 2008年-2013年; 国家自费留学生优秀留学生奖学金, 证书编号 2012-390, 2012 年;日本东京大学科长奖,优秀博士毕业生,2013年;第三届全球新材料行业大赛,一等奖(总决赛),2016;日本第一届创新创业大赛,一等奖(总决赛),2016;深圳第一届创新创业大赛,二等奖(日本赛区),2017。
    • 性别 : 男
    • 出生年月 : 1985-08-20
    • 在职信息 : 非事业编
    • 所在单位 : 生命科学与技术学院
    • 学科 : 生物医学工程 药物工程 高分子材料
    • 办公地点 : 生物科学与技术楼 205室
    • 联系方式 : 手机:15734185256, 18868369147; 邮箱:qixian@dlut.edu.cn, qixian@mit.edu
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    个人简介

    陈麒先,大连理工大学生命与科学技术学院特聘研究员,大连理工大学"星海青年千人"入选者。出生于1985年08月,辽宁大连人。2003年-2008年就读于大连理工大学,以优异的成绩获得材料物理专业理学学士学位以及英语专业文学学士学位。2008年10月,通过日本文部省奖学金项目,赴日本东京大学材料工学系跟随国际著名生物材料科学家Prof. Kazunori Kataoka(片冈一则教授,美国工程院院士)攻读硕士及博士学位,在博士期间取得了丰硕的学术成果,在国际著名学术期刊 Nature Nanotechnology、Nature Communications、ACS Central Science、Biomaterials、Journal of Controlled Release、Molecular Therapy 等发表论文40余篇,其中18篇为第一作者或通讯作者,总影响因子超过300分,被他人引用超过1400次,受到国际同行的广泛关注。2013年受邀成为Advances in Science旗下期刊的编委。在硕士和博士期间表现优异,2012年获得中国政府针对海外留学人员颁发的国家优秀留学生奖(全球每年500名),2013年代表东京大学工学部领取了最优秀博士生科长奖(东京大学每个学部仅1名)。2013年完成博士研究课题以及相关独立博士后研究项目,应美国麻省理工学院化学系 Prof. Jeremiah A. Johnson 邀请担任博士后研究员致力化学、生物、医学交叉研究工作,并且同时担任麻省理工学院癌症研究中心,美国麻省总医院癌症中心做临床转化工作。陈麒先博士在纳米医学领域,尤其在应用基因和药物载体系统治疗顽固性癌症以及阿尔海默脑萎缩疾病方面获得了重大的突破。

    第一作者或通讯作者:
    1. Q. Chen, K. Osada*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka*, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors, Biomaterials, 33, 18, 4722, 2012. (影响因子:8.402)
    2. Q. Chen, K. Osada*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka*, Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials, 113, 253, 2016. (影响因子:8.402)
    3. Q. Chen#,*, R. Qi#, X. Chen, H. Xiao, W. Dong*, Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression. ACS Applied Materials & Interfaces, 8, 24404, 2016. (影响因子:7.504)
    4. Q. Chen#,*, R. Qi, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong*, A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors. Molecular Therapy, 25(1), 92, 2017. (影响因子:6.688)
    5. Q. Chen, K. Osada*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka*, Tadpole-shaped gene carrier with distinct phase segregation in ternary polymeric micelle, Soft Matter, 11, 14, 2718, 2015. (影响因子:3.889)
    6. Z. Ge#, Q. Chen#, K. Osada*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka*, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors, Biomaterials, 35, 10, 3416, 2014. (影响因子:8.402)
    7. J. Li#, Q. Chen#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka*, and Z. Ge*, Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery, Journal of Controlled Release, 209, 77, 2015. (影响因子:7.786)
    8. X. Han#, Q. Chen#, H. Lu, J. Ma, H. Gao*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative. ACS Applied Materials & Interfaces, 7, 28494, 2015. (影响因子:7.504)
    9. X. Han#, Q. Chen#, W. Lu, G. Wu, J. Ma, H. Gao*, Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form. Chemical Communications, 52, 3907, 2016. (影响因子:6.319)
    10. T. Wang#, Q. Chen#, W. Li, G. Wu, J. Ma, H. Gao*, Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing. Bioconjugate Chemistry, 27, 1949, 2016. (影响因子:4.818)
    11. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen*, H. Gao, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Applied Materials & Interfaces, 7, 23760, 2015. (影响因子:7.504)
    12. Y. Li, J. Li, B. Chen, Q. Chen*, G. Zhang, Z. Ge*, S. Liu, Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection, Biomacromolecules, 15, 8, 2914, 2014. (影响因子:5.246)
    13. J. Li, Y. Han, Q. Chen*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge*, S. Liu, Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin, Journal of Materials Chemistry B, 2, 13, 1813, 2014. (影响因子:4.453)
    14. Y. Wu, Q. Chen*, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016. (影响因子:4.453)
    15. X. Yang, Q. Chen*, J. Yang, S. Wu,  J. Liu,  Z. Li, D. Liu,  X. Chen, Y. Qiu*, Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness. ACS Applied Materials & Interfaces, 2017. (影响因子:7.504)
    16. Z. Jiang, Q. Chen*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao*, Polyplex Micelle with pH-Responsive PEG Detachment and Functional Tetraphenylene Incorporation to Promote Systemic Gene Expression. Bioconjugate Chemistry, 28 (11), 2849–2858, 2017.(影响因子:4.818)
    17. J. Yang , R. Liang, Y. Chen*,  C. Zhang,  R. Zhang, X. Wang, R. Kang, Q. Chen*, Using a Self-Assemblable Nucleating Agent to Tailor Crystallization Behavior, Crystal Morphology, Polymorphic Crystalline Structure, and Biodegradability of Poly(1,4-butylene adipate). Industrial & Engineering Chemistry Research 56(28), 7910-7919, 2017.(影响因子:2.843)
    18. Z. Li, Y. Wi, Z. Liu, T. Hao, L. Qiu, X. Sun, M. Qiao, H. Hu, X. Zhao, Q. Chen*, D. Chen*, Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-Vitamin E Succinate for reversing multidrug resistance of doxorubicin, ACS Applied Materials & Interfaces, 2017. (影响因子:7.504)

    其他共同作者:
    19. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size, Nature Nanotechnology, 6, 12, 815, 2011.(影响因子:38.986)
    20. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang, Fabrication and physical properties of poly(Epsilon-caprolactone)/modified graphene nanocomposite. Macromolecular Materials and Engineering, 302(3), 2016. (影响因子:2.863)
    21. K. Itaka, S. Uchida, Q. Chen, T. Ishii, K. Osada, K. Kataoka, Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses, Human Gene Therapy, 10, 22, 88, 2011. (影响因子:3.380)
    22. S. Uchida, K. Itaka, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses, Molecular Therapy, 20, 6, 1196, 2012.(影响因子:6.688)
    23. F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles, Journal of Controlled Release, 161, 3, 868, 2012. (影响因子:7.786)
    24. T. A. Tockary, K. Osada, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers, Macromolecules, 46, 16, 6585, 2013. (影响因子:5.835)
    25. A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors, Biomaterials, 35, 20, 5359, 2014. (影响因子:8.402)
    26. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka, Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity, Chemical Communications, 51, 15, 3158, 2015. (影响因子:6.319)
    27. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression, Biomacromolecules, 16, 2664, 2015. (影响因子:5.583)
    28 Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang, Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate. European Polymer Journal, 72, 222, 2015. (影响因子:3.531)
    29. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery, Chemical Communications, 51, 4715, 2015. (影响因子:6.567)
    30. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka, Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 12, 1193, 2016. (影响因子:8.643)
    31. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge, Self-sufficing H2O2-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy. Journal of Controlled Release, 225, 64, 2016. (影响因子:7.786)
    32. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen, Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy. Biomaterials, 100, 118, 2016. (影响因子:8.402)
    33. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition. Journal of Materials Chemistry B, 4, 6350, 2016. (影响因子:4.453)
    34. X. Yang, W. Li, Q. Chen, M. Li, R. Qi, Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment. Nanomedicine: nanotechnology, Biology and Medicine, 13, 287, 2016. (影响因子:5.720)
    35. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression. Biomacromolecules, 18, 36, 2017. (影响因子:5.246)
    36.  H. V.-T.  Nguyen, Chen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D.  Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson, Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors. ACS Central Science 3, 800-811, 2017. (影响因子: 7.939)
    37. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems. Journal of Materials Chemistry B, 5, 8322, 2017. (影响因子:4.453)
    38. Hui Wu, Xi Yang, Ran Wang, Qixian Chen, Ruogu Qi, Xing Huang, Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance. Materials Science & Engineering C, 2017. (影响因子:4.164)
    39. Ruogu Qi, Yongheng Wang, Peter Bruno, Haihua Xiao, Yingjie Yu, Ting Li, Samuel Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pépin, Michael Hemann, Michael Birrer,  Paiman Ghoroghchian. Nanoparticle-conjugates of a Highly Potent Toxin Enhance Safety and Circumvent Platinum Resistance in Ovarian Cancer, Nature Communications, 2017. (影响因子:12.124)
    40. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye, Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating. Energy Storage Materials, 2017.(即时影响因子:12.38)
    41. Dee Liu, Qixian Chen, Jianbiao Ma, Hui Gao, Thermo-responsive Organogel as Transdermal Drug Delivery system. Polymer Chemistry, 2017.(影响因子:5.375)
    42. Ruogu Qi, Sanyan Le, Qiang Yang, Qixian Chen, Nanoparticle mediated delivery of satraplatin to overcome cisplatin drug resistance, ACS Applied Nano Materials, 2017.
    43. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao, Dual functionalized amino poly (glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. Journal of Materials Chemistry B, 3, 6911, 2015. (影响因子:4.453)
    44. S. Uchida, K. Itaka, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity, Journal of Controlled Release, 155, 2, 296, 2011. (影响因子:7.786)

    专利及知识产权(发明专利)
    专利 1(美国):Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and the method for nucleic acid delivery. Patent No.: US9314529B2. Inventors: Kazunori Kataoka, Takehiro Ishii, Kensuke Osada, Qixian Chen, Keiji Itaka, Satoshi Uchida. Approved Date: Apr. 19, 2016.
    专利 2(美国):Bottlebrush copolymers and uses thereof. Patent application No.: US62404098. Inventors: Jeremiah Johnson, Qixian Chen. Filing Date: Oc. 04, 2016.
    专利 3(日本): 核酸送達用組成物及び担体組成物、それを用いた医薬組成物、並びに核酸送達方法; 特許第5826174号(JP5826174); 片岡一則、石井武彦、長田健介、陳麒先、位高啓史、内田智士;【発行国】日本国特許庁(JP)【公報種別】特許公報(B2)【特許番号】5826174【登録日】2015年10月23日【発行日】2015年12月2日。
    专利 4 (欧洲): Zusammensetzung zur nukleinsäureabgabe, trägerzusammensetzung, pharmazeutische zusammensetzung mit der zusammensetzung zur nukleinsäureabgabe oder der trägerzusammensetzung und verfahren zur nukleinsäureabgabe (德语) Composition d'administration d'acides nucléiques, composition d'excipient, composition pharmaceutique contenant la composition d'administration d'acides nucléiques ou la composition d'excipient et méthode d'administration d'acides nucléiques (法语)Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid(英语). Patent No.: EP2591792. Inventors: Kazunori Kataoka, Takehiro Ishii, Kensuke Osada, Qixian Chen, Keiji Itaka, Uchida Satoshi. Approved Date: Dec. 21, 2016.
    专利 5(中国):高分子水凝胶、其制备方法及其应用;申请号:201610343757.X;发明人:陈麒先、刘俊;申请日:2016.05.19。
    专利 6(中国):纳米药物存储器、其制备方法及其应用;申请号:201610334823.7;发明人:陈麒先、刘俊;申请日:2016.05.19。
    专利 7(中国):核酸递送用组合物及载体组合物、使用其的药物组合物以及核酸递送方法;申请号: 201180032323.3;发明人:片冈一则、石井武彦、长田健介、陈麒先、位高启史、内田智士;申请日: 2011.07.11。
    专利 8(中国):一种金属有机骨架聚阳离子衍生物及其制备方法和应用;发明人:陈麒先;申请日:2017.05.19。
    专利 9(中国):一种复合蛋白质脂质体纳米制剂;申请号:20710773412.2;发明人:陈麒先、刘俊;申请日:2017.08.31。

    教育经历

    2010.10 -- 2013.9
    东京大学       材料工程       博士

    2008.10 -- 2010.9
    东京大学       材料工程       工学硕士

    2007.9 -- 2008.6
    大连理工大学       英语       文学学士

    2003.9 -- 2007.6
    大连理工大学       材料物理       理学学士

    工作经历

    2017.7 -- 至今

    大连理工大学      生命科学与技术      特聘研究员      在职

    2015.4 -- 2017.3

    麻省理工学院      化学系&癌症研究中心      博士后研究员

    2013.11 -- 2015.3

    东京大学      工学院      特任研究员

    社会兼职

  • 2015.7 -- 至今

    国际期刊编委:Advances in Pharmacognosy and Phytomedicine

  • 2012.7 -- 至今

    国际期刊编委:Advances in Biology, Biotechnology and Genetics

  • 研究方向

  • ^-^具有响应性,功能性的生物水凝胶:针对人类重大慢性病(如眼科疾病:白内障,葡萄糖膜炎等疾病)以及人类重大疾病(原发或复发性恶性癌症等)开发的的高度可控的模块化介入型的纳米药物缓释体技术。

  • ^-^克服血脑屏障的高渗透药物递送系统:针对脑退化疾病(阿尔海默病、帕金森病等)开发高效通透血脑屏障(BBB)的药物递送系统,实现靶向输送药物到神经元细胞或胶质细胞。

  • ^-^肿瘤高靶向性、高渗透性纳米药物递送系统的研究:构建多功能、环境响应型、靶向性、智能化的聚合物纳米药物递送系统,通过对聚合物高分子的分子结构及其组装的纳米精准控制,实现对各类恶性肿瘤实现高效的治疗效果。

  • ^-^基因药物递送系统的开发和应用:通过设计合成安全高效的基因递送功能分子,构建了包载DNA的纳米输运载体,通过对DNA凝缩理论的系统和深入研究,实现了对包载凝缩DNA纳米运载体的尺寸、形状和形状的精准控制,在病灶部位实现了持续高效的表达要用蛋白质。

  • 团队成员

    纳米医学