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Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells

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Indexed by:期刊论文

First Author:Mehdi, Hassan

Correspondence Author:Gong, WT; Ning, GL (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, Sch Chem Engn, Dalian 610023, Peoples R China.; Watkinson, M (reprint author), Queen Mary Univ London, Sch Biol & Chem Sci, Joseph Priestley Bldg,Mile End Rd, London E1 4NS, England.

Co-author:Gong, Weitao,Guo, Huimin,Watkinson, Michael,Ma, Hua,Wajahat, Ali,Ning, Guiling

Date of Publication:2017-09-21

Journal:CHEMISTRY-A EUROPEAN JOURNAL

Included Journals:Scopus、SCIE、EI、PubMed

Volume:23

Issue:53

Page Number:13067-13075

ISSN No.:0947-6539

Key Words:aggregation-induced emission; bioimaging; fluorophores; sensors; zinc

Abstract:Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn2+ in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single-crystal X-ray diffraction, which revealed an intricate crystal packing system. Conversely, a fluorophore that lacks the isobutylene moiety did not exhibit any significant fluorescent properties as a result of its more flexible molecular structure that presumably allows free intramolecular rotational processes to occur.

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