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Supramolecular Kandinsky circles with high antibacterial activity


Indexed by:期刊论文

Date of Publication:2021-01-27




ISSN No.:2041-1723

Key Words:antibiotic agent; daptomycin; ligand; antiinfective agent; ligand; nanomaterial, antimicrobial activity; bacterium; eukaryote; ligand; molecular analysis; nanomaterial; pathogen, antibacterial activity; antibiotic resistance; Article; column chromatography; controlled study; drug cytotoxicity; drug design; drug isolation; drug mechanism; drug potency; drug selectivity; drug synthesis; electrospray mass spectrometry; geometry; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; molecular weight; nonhuman; polymerization; static electricity; supramolecular chemistry; Suzuki reaction; time of flight mass spectrometry; atomic force microscopy; chemical phenomena; chemistry; drug effect; isolation and purification; macromolecule; microbial sensitivity test; microbiology; pharmacology; proton nuclear magnetic resonance; Staphylococcus infection; transmission electron microscopy, Eukaryota; methicillin resistant Staphylococcus aureus; Posibacteria, Anti-Bacterial Agents; Drug Resistance, Bacterial; Hydrophobic and Hydrophilic Interactions; Ligands; Macromolecular Substances; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Weight; Nanostructures; Proton Magnetic Resonance Spectroscopy; Staphylococcal Infections

Abstract:Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra) molecular level. Herein, three generations (G2-G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.

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