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论文类型：期刊论文

发表时间：2017-11-30

发表刊物：Marine pollution bulletin

收录刊物：Scopus、SCIE、EI、CPCI-S、PubMed

卷号：124

期号：2

页面范围：847-855

ISSN号：1879-3363

关键字：Gonadosomatic index,Growth rate,Heartbeat,Reproduction,Swimming activity

摘要：Toxic effects of triphenyltin (TPT) to different life stages of the marine medaka Oryzias melastigma were investigated through a series of life-cycle based exposure experiments. In embryo stage, TPT exposure could elevate the heartbeat rate at Day 6-8 post-fertilization and increase the expression levels of five heart development related genes (i.e., ATPase, COX2, BMP4, GATA4 and NKX2.5). In larval stage, TPT shortened the body length at ≥10μg/L and suppressed the swimming activity of the fish larvae at Day 1 post-hatching at 50μg/L. In reproductive stage, TPT exposure resulted in a male-biased sex ratio (2μg/L) and reduced the gonadosomatic index (GSI) in females (≥ 0.1μg/L), which might in turn lead to a decline in their population fitness. The reproductive stage of O. melastigma was more sensitive to TPT than other stages, while the GSI of female medaka was the most sensitive endpoint.Copyright © 2017 Elsevier Ltd. All rights reserved.