陈广义

个人信息Personal Information

副教授

硕士生导师

性别:男

毕业院校:吉林大学

学位:博士

所在单位:机械工程学院

学科:车辆工程. 材料学

办公地点:汽车学院实验室A303

联系方式:18941135528

电子邮箱:chengy@dlut.edu.cn

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Hemocompatibility evaluation of polyurethane film with surface-grafted poly(ethylene glycol) and carboxymethyl-chitosan

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论文类型:期刊论文

发表时间:2013-01-05

发表刊物:JOURNAL OF APPLIED POLYMER SCIENCE

收录刊物:SCIE、EI、Scopus

卷号:127

期号:1

页面范围:308-315

ISSN号:0021-8995

关键字:graft modification; carboxymethyl-chitosan; hemocompatibility

摘要:To improve the hemocompatibility and biocompatibility of polyurethanes (PUs), PU surface was firstly modified by poly(ethylene glycol) PEG through acryloyl chloride and subsequently grafted on carboxymethyl-chitosan (CMCS). Attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analysis confirmed that carboxyl-chitosan was grafted onto PUs surface. The surface properties of unmodified and modified PU films were determined and compared by water contact angle assessment. After PEG and CMCS grafting, the surface energy of the PU film was increased. Furthermore, the hemocompatibility of the modified PU films was systematically evaluated by bovine serum albumin (BSA) adsorption, the dynamic blood clotting test, the platelet adhesion test, and the hemolytic test. It appears that BSA adsorption and platelet adhesion were significantly curtailed for the modified PU films. Therefore, the obtained results showed the modified PU film has better hemocompatibility. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012