Hits:

Indexed by:期刊论文

Date of Publication:2015-01-01

Journal:CHINESE CHEMICAL LETTERS

Included Journals:SCIE、ISTIC、CSCD

Volume:26

Issue:1

Page Number:55-57

ISSN No.:1001-8417

Key Words:Pyridine N-oxides; Arylation; Palladium; Suzuki reaction; Water

Abstract:We report a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in water. This ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gives 2- or 3-arylated pyridyl N-oxide derivatives in good to excellent yields within 1 h. (C) 2014 Chun Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.