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Synthesis of Naphthalimine-derived Dye and Its Applications in Fluorescent Imaging and Dyeing Surgical Suture Materials
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Indexed by:Journal Papers

First Author:Xiong, Xiaoqing

Correspondence Author:Xiong, XQ; Zheng, LJ (reprint author), Dalian Polytech Univ, Key Lab Ecol Text, 1 Qinggongyuan, Dalian 116034, Peoples R China.; Xiong, XQ (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China.

Co-authors:Zheng, Laijiu,Zhi, Weiru,Yan, Jun,Song, Wenjing,Du, Hui,Zhao, Hongjuan,Li, Feixia,Song, Fengling,Sun, Yanfeng

Date of Publication:2018-03-22

Journal:CHEMISTRYSELECT

Included Journals:SCIE

Volume:3

Issue:11

Page Number:3345-3350

ISSN No.:2365-6549

Key Words:Absorbable collagen surgical suture; Fluorescence imaging; Fluorescent warning materials; Indometacin; Naphthalimine

Abstract:In this study, NP-indometacin, which was based on the two-photon naphthalimine, was designed and synthesized. The anti-inflammatory material indometacin was introduced into NP-indometacin so that the toxicity of this fluorescent dye was reduced when applied to living organisms. NP-indometacin had high fluorescence quantum efficiency (0.98 in DMSO), a large Stokes shift (>77nm) and feasible two-photon action cross section (45 GM in DMSO). NP-indometacin was utilized for the fluorescence imaging of living cells, and the high cell viability rate (>80%) indicated that this material had low toxicity in living organisms. NP-indometacin was used to dye absorbable collagen surgical suture and constructed fluorescent surgical suture. It was found by one- and two-photon fluorescence imaging that NP-indometacin distributed uniformly both outside and inside the sutures. Therefore, the straightforward synthesis of NP-indometacin and the wide availability of its constituents mean that it could both be highly useful for the observation of the healing of wounds and as a fluorescent warning material that is used in vivo.

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Alma Mater:Dalian University of Technology

Degree:Doctoral Degree

Status:On the job

School/Department:State Key Laboratory of Fine Chemicals

Discipline:Applied Chemistry Organic Chemistry Physical Chemistry (including Chemical Physics)

Business Address:E228 West Campus, 2 Linggong Rd.,Dalian, Liaoning, 116024, P. R. China

Contact Information:Email: songfl@dlut.edu.cn Tel: 86-411-84986307

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