宋锋玲
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A dual-targeted theranostic photosensitizer based on a TADF fluorescein derivative
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Indexed by:Journal Papers

First Author:Liu, Zhiwei

Correspondence Author:Xiong, XQ (reprint author), Dalian Polytech Univ, Key Lab Text Cleaning, 1 Qinggongyuan, Dalian, Peoples R China.; Song, FL (reprint author), Inst Mol Sci & Engn, 72 Binhai Rd, Qingdao, Shandong, Peoples R China.

Co-authors:Shi, Wenbo,Hong, Gaobo,Chen, Wenlong,Song, Bo,Peng, Xiaojun,Xiong, Xiaoqing,Song, Fengling

Date of Publication:2019-09-28

Journal:JOURNAL OF CONTROLLED RELEASE

Included Journals:SCIE、PubMed、EI

Volume:310

Page Number:1-10

ISSN No.:0168-3659

Key Words:Dual-targeted; Cancer theranostics; Thermally activated delayed fluorescence; Photodynamic therapy; Photosensitizers

Abstract:Specific diagnosis and therapy of cancer is still a challenge in biomedical research. Photodynamic therapy (PDT) has emerged as a novel therapeutic modality for cancer treatment. However, the traditional PDT photosensitizers often exhibit low specific selectivity. In this study, we have reported a dual-targeted theranostic photosensitizer FL-RGD by covalently conjugating tumor marker cyclic arginine-glycine-aspartic acid tripeptide (RGD) and a fluorescein derivative FL which has a property of thermally activated delayed fluorescence (TADF) and a long triplet lifetime for efficient PDT. The FL-RGD can target tumor tissues and further locate lysosomes of tumor cells to concurrently achieve the cancers' specific diagnosis and efficient treatment. The mechanism of its highly efficient PDT was attributed to the damage of lysosome via O-1(2). Besides, FL-RGD has the potential to be utilized in depth imaging and treatment by two-photon excitation. The actual diagnosis performance of FL-RGD was proved by fluorescence imaging of living cells and tumor bearing mice. The therapy performance was proved by MTT assays, fluorescence-activated cell sorting (FACS) analysis and PDT experiments on tumor bearing mice. The research obviously exhibited the potential of FL-RGD for tumor theranostics in vivo and in vitro.

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Gender:Male

Alma Mater:Dalian University of Technology

Degree:Doctoral Degree

Status:On the job

School/Department:State Key Laboratory of Fine Chemicals

Discipline:Applied Chemistry Organic Chemistry Physical Chemistry (including Chemical Physics)

Business Address:E228 West Campus, 2 Linggong Rd.,Dalian, Liaoning, 116024, P. R. China

Contact Information:Email: songfl@dlut.edu.cn Tel: 86-411-84986307

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Address: No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024

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