教育经历：

1998年09月-2002年07月 大连理工大学化工学院生物工程系 生物工程学士(本科)，导师：杨 青 教授

2002年09月-2008年10月 大连理工大学生物科学与技术学院 生物化工博士(直博)，导师：杨 青 教授、安利佳 教授

2005年04月-2005年12月 瑞典Uppsala Universitet生物医学中心表面生物技术系 访问学者 导师：Jan-Christer Janson 教授(PhD)

2009年02月-2014年09月 瑞典Karolinska Institutet医学生物化学与生物物理系 博士后
  导师：Elias S.J. Arner 教授(PhD,MD) 

学术兼职：

中国生物物理学会 生物微量元素分会    委员  (2021-12---2026-12)

欧洲自由基生物学与医学学会(SfRBM)投票会员  (2022-02---2026-02）voting member

国际铁生物学与医学学会(BioIron)  投票会员  (2023-03---2025-03）voting member

中国生物物理学会 氧化还原生物学与医学分会  青年委员  (2024-07---至今)

中国生理学会 基质生物学专业委员会          青年委员  (2016-12---至今)

工作经历：

2014年09月-2020年03月，  大连理工大学 生命与医药学院           科研秘书


2015年06月-2017年06月，  大连理工大学 盘锦校区科研与学科工作部 部长助理 (挂职)

2015年12月-2019年09月，  大连理工大学 生命与医药学院           副教授

2016年09月-至今          大连理工大学 盘锦校区侨联             秘书长

2016年03月-2017年12月，  大连理工大学 盘锦产业技术研究院       院长助理

2018年01月-至今          大连理工大学 盘锦产业技术研究院       副院长

2019年09月-2023年12月，  大连理工大学 生命科学与药学学院       副教授

2023年12月-至今          大连理工大学 化工海洋与生命学院       副教授

学术服务：

2021年08月-至今  EI期刊《精细化工》(生物化工、医药化工)                编委

2022年01月-至今  Frontiers旗下期刊Frontiers in Pharmacology    副编辑、编委（Associate Editor,EMB）

2022年01月-至今  Frontiers旗下期刊Frontiers in Oncology        副编辑、编委（Associate Editor,EMB）

2024年01月-至今  Elsevier旗下期刊Biomedicine & Pharmacotherapy 副编辑、编委（Associate Editor,EMB）

2024年09月-至今  Springer-Nature 旗下期刊 Scientific Reports           编委                 （EMB）

刊物审稿：

担任STTT、RB、BcP、Food Bioscience, Antioxidants、Nutrients、Biomedicines及Frontiers in Microbiology、Frontiers in Immunology、Frontiers in Cell & Developmental Biology、Frontiers in Molecular Biosciences等期刊审稿编辑（Review Editor）或同行评审（peer reviewer）。

学术记录：

个人ORCID: 0000-0002-1289-5943

个人PubMed ID: 58002586

个人Scopus ID: 48061598700

个人Pulons ID: T-7507-2019

Researcher ID: 3024651

https://www.researchgate.net/profile/Jianqiang_Xu3

https://loop.frontiersin.org/people/299382/overview

https://publons.com/researcher/4382717/jianqiang-xu/

http://faculty.dlut.edu.cn/jianqiang_xu/en/index.htm

https://www.semanticscholar.org/author/Jianqiang-Xu/2754072

https//www.webofscience.com/wos/author/record/30404783

https://www.mendeley.com/profiles/jianqiang-xu5/

https://sciprofiles.com/profile/1832946

关于科研：

课题组近五年主要聚焦“肿瘤细胞耐药干预、细胞死亡命运调控”，以硒蛋白TXNRD1/2和GPX1/4等作为胞内靶标，开展植源性有效成分、FDA-approved小分子药物、含Au/Pt化合物(complex)、免疫佐剂及纳米载体递送系统的药效药理研究，在in vitro 细胞水平实验研究（本实验室）、in vitro 分子酶学检测验证（本实验室）、in vivo 小动物模型实验验证（校际合作），陆续取得系列进展。

关于我们：

1. 选拔优异本科生开展3年期project：成为实验室固定成员、参加组会讨论、参与卫生安全和仪器维护、总结、撰写并发表文章；

2. 欢迎兄弟院校 优秀生源 推荐保送，或 考取 本课题组攻读硕士研究生：(生物学_学硕；生物技术与工程_专硕；制药工程_专硕).

关于感悟：

古语有云:  至大无外，至小无内。生物医学药学正是这样一门历久弥新、贴近人体、承接地气的学科。

微小至踪迹漂渺的病毒粒子和细菌真菌，介观放大至蔓布旷野山川的动物植物亦或高维文明生命体系。

人类祖先可能很早就意识到碳基生命的一生短暂和序维单向、认识到宇宙洪荒的亘古恢宏与无限壮丽。

正是人类健康疾病的众多挑战和冗余要求，使得人类不断推进新里程，增进对自身和自然的深入理解。

人生短暂、自然永续。今世一生，研而无憾。生而为人、学而有为。

期待你的大成、智慧、灵光闪现，慎重考虑、加盟硒生物学实验室，

让我们一起努力进步、攻伐有趣、探索新知、洞悉未知、触碰未来！

代表文章：（# 共同第一作者； * 通讯作者）

2025

2024

(1) H. Liu#, S. Sun#, M. Shi, Y. Yang, W. Shi, Y. Meng, H. Zhou, X. Yan, M. Xu, H. Liu, K. Ma, C. Cui, W. Xu, Z. Ye, J. Zhang, C. Hung, J. Xu*.  Journal of Biological Chemistry, 2024,  under review. 

(2) L. Wang#, S. Sun#, H. Liu, Q. Zhang, Y. Meng, F. Sun, J. Zhang, H. Liu, W. Xu, Z. Ye, J. Zhang, B. Sun, J. Xu*. Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells, FEBS Journal. 2024, in press   [JCR Q1, SCI_IF=5.5]

(3) R. Yang#, S. Sun#, Q. Zhang#, H. Liu, L. Wang, Y. Meng, N. Chen, Z. Wang, H. Liu, F. Ji, G. He, W. Xu, Z. Ye, J. Zhang, Q. Ma*, J. Xu*. Pharmacological inhibition of TXNRD1 by a small molecule flavonoid butein overcomes cisplatin resistance in lung cancer cells, Biological Trace Element Research. 2024, in press   [JCR Q2, SCI_IF=3.4]

(4)  D. Wang#, F. Zhou#, L. He, X. Wang, L. Song, H. Wang, S. Sun, Z, Guo, K. Ma, J. Xu*, C. Cui*.  AML cell‐derived exosomes suppress the activation and cytotoxicity of NK cells in AML via PD‐1/PD‐L1 pathway. Cell Biology International, 2024, 48(10):1588-1598.   [JCR Q3, SCI_IF=3.3]

(5) S. Sun#, H. Liu#, W. Shi, H. Zhou, H. Wu, W. Xu*, J. Xu*. Protocol for assaying irriversible inhibitors of thioredoxin reductase 1. Star Protocols. 2024, 5(3):103235.    [Cell旗下实验方法杂志，SCI_IF=1.3]

(6) W. Shi#, S. Sun#, H. Liu#, Y. Meng, K. Ren, G. Wang, M. Liu, J. Wu, Y. Zhang, H. Huang, M. Shi, W. Xu, Q. Ma, B. Sun, J. Xu*.  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox Biology. 2024, 70:103050.  [JCR Q1;  中科院 I 区 TOP, SCI_IF=11.4]

(7) M. Yan, N. Zhang, X. Li, J. Xu, H. Lei, Q. Ma*. Integrating Post-Ionization Separation via Differential Mobility Spectrometry into Direct Analysis in Real Time Mass Spectrometry for Toy Safety Screening. Analytic Chemistry. 2024, 96(1):265-271. [JCR Q1;  中科院 I 区 TOP ]

(8) Y. Meng#, S. Sun#, ..... J. Xu*, Redox Biology, submitted,

2023

 (1) M. .Liu#, S. Sun#, Y.   Y. Meng, L. Wang, H. Liu, W. Shi, Q. Zhang, W. Xu, B. Sun, J. Xu*. Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase. Molecules, 2023, 28(19): 6842.  [JCR Q2; SCI_IF=4.9]

(2)  R. Yang#, S. Sun#, Y. Guo, Y. Meng, H. Liu, M. Shi, S. Guan*, J. Xu*. Anti-inflammatory effect of dimethyl fumarate associates with the inhibition of thioredoxin reductase 1 in RAW 264.7 cells. Molecules, 2023, 28:107. [JCR Q2; SCI_IF=4.9]

(3)   H. Wang#, S. Sun#, Y. Ren#, R. Yang, Y. Zong, Q. Zhang, J. Zhao, W. Zhang, W. Xu, S. Guan, J. Xu*, Selenite ameliorates cadmium-induced cytotoxicity through down- regulation of ROS levels and up-regulation of selenoprotein thioredoxin reductase 1 in SH-SY5Y cells, Biological Trace Element Research, 2023, 201:139-148.   [ JCR Q2;  SCI_IF=3.9]

(4)  X. Chen#, S. Sun#, S. Huang#, Y. Liang, H. Yang, L. Lv, J. Shan, J. Xu*, W. Liu*, T. Ma*. Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase, Redox Biology, 2023, 60:102621.    [JCR Q1;   中科院 I 区 TOP, ]

(5)  J. Xu*, A. Vlamis-Gardikas*, J. Fang*. Small molecule inhibitors targeting mammalian selenoprotein thioredoxin reductases (TXNRDs): Interactions, mechanisms, and applications. Frontiers in Molecular Biosciences. 2023, 10:1141772.    [JCR Q1;   中科院 II 区 ]

(6)  Y. Liu, J. Liu, J. He, H. Lu, S. Sun, F. Ji, X. Dong, Y. Bao, J. Xu*, G. He, W. Xu*. Chronological and carbohydrate-dependent variation of fatty acids of black soldier fly larvae in food waste treatment. Molecules, 2023, 28:1903.    [JCR Q2;   SCI_IF=4.9]

(7) J. Zhang*# , Z. Ye# , L. Bräutigam, P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. Journal of Biological Chemistry, 2023, 299(8):104920.    [ JCR Q2; 中科院 II 区 TOP ]

(8) J. Zhang*# , Z. Ye# , P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma. Pharmacological Research, 2023, 196:106899.   [JCR Q1; 中科院 I 区 TOP ]

2022

(1)  S. Guan*, Y. Wang, F. Xie, S. Wang, W. Xu, J. Xu*, C. Sun*. Carboxymethyl chitosan and gelatin hydrogel scaffolds incorporated with conductive PEDOT nanoparticles for improved neural stem cell proliferation and neuronal differentiation. Molecules, 2022, 27:8326.  [ JCR Q2;   中科院 III 区 ]

(2) Y. Yan, S. Guan*, S. Wang, J. Xu, C. Sun*. Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff's base reaction.   International Journal of Biological Macromolecules, 2022, 222:2581-2593.   [ JCR Q1;   中科院 II 区 ]

(3) Z. Xu, J. Xu, S. Sun, W. Lin, Y. Li, Q. Lu, F. Li, Z. Yang, Y. Lu, W. Liu*, Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma, Redox Biology, 2022, 54:102351.      [JCR Q1;   中科院 I 区 TOP ]

(4)  Y. Yang#, S. Sun#, W. Xu, Y. Zhang, R. Yang, K. Ma, J. Zhang, J. Xu*, Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin, Antioxidants, 2022, 11:710.    [JCR Q1;   中科院 II 区 ]

(5)   Y. Zhang#, S. Sun#, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, K. Ma, J. Xu*, Thioredoxin reductase inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling, Free Radical Biology & Medicine, 2022, 180:52-62.      [ JCR Q1 TOP;   中科院 II 区 ]

(6)   S. Sun, Y. Zhang, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Zhang, J. Xu*, Plumbagin reduction by thioredoxin reductase 1 possesses synergy effects with GLUT1 Inhibitor on KEAP1-mutant NSCLC cells, Biomedicine & Pharmacotherapy, 2022, 146(33):112546.    [ JCR Q1;   中科院 II 区 ]

(7) N. Jin#, Y. Liu#, S. Zhang, S. Sun, M. Wu, X. Dong, H. Tong, J. Xu, H. Zhou, S. Guan, W. Xu*. C/N-Dependent element bioconversion efficiency and antimicrobial protein expression in food waste treatment by black soldier fly larvae. International Journal of Molecular Sciences, 2022, 23(9):5036.   [ JCR Q1;   中科院 II 区 ]

(8)  S. Zhang#, P. Xiong#, Y. Ma, N. Jin, S. Sun, X. Dong, X. Li, J. Xu, H. Zhou, W. Xu*. Transformation of food waste to source of antimicrobial proteins by black soldier fly larvae for defense against marine Vibrio parahaemolyticus. Science of the Total Environment. 2022, 826:154163.   [ JCR Q1;   中科院 II 区 ]

2021

(1)   S. Sun, Y. Zhang, W. Xu, Y. Zhang, R. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Xu*, Chlorophyllin inhibits mammalian thioredoxin reductase 1 and triggers cancer cell death, Antioxidants, 2021, 10:1733.     [ JCR Q1;   中科院 II 区 ]

(2)   S. Sun#, W. Xu#, Y. Zhang, Y. Yang, Q. Ma*, J. Xu*, Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution. Free Radical Biology & Medicine, 2021, 172:482-489.   [ JCR Q1;   中科院 II 区 ]

(3)   K. Ma#, W. Li#, G. Zhu, S. Sun, H. Chi, Y. Yin, H. Diao, X. Xing, Z. Guo, L. Wang, W. Xu, C. Cui, J. Xu*. Functionalized PDA/DEX-PEI@HA nanoparticles combined with sleeping- beauty transposons for multistage targeted delivery of CRISPR/Cas9 gene, Biomedicine & Pharmacotherapy, 2021, 142:112061.  [ JCR Q1;   中科院 II 区 ]

(4)   S. Sun#, W. Xu#, H. Zhou, Y. Zhang, J. Zhang, X. Li, B. Li, K. Ma, J. Xu*, Efficient purification of selenoprotein thioredoxin reductase 1 by using chelating reagents to protect the affinity resins and rescue the enzyme activities, Process Biochemistry, 2021, 101:256-265.  [ JCR Q2;   中科院 III 区 ]

(5)   K. Ma#, W. Li#, G. Zhu, H. Chi, Y. Yin, Y. Li, Y. Zong, Z. Guo, L. Wang, W. Xu, C. Cui, H. Zhou, J. Xu*, PEGylated DOX-coated nano graphene oxide as pH-responsive multifunctional nanocarrier for targeted drug delivery, Journal of Drug Targeting, 2021, 29(8):884-891.    [ JCR Q2;   中科院 III 区 ]

(6)  J. Xu, J. Fang*, How can we improve the design of small molecules to target thioredoxin reductase for treating cancer? Expert Opinion on Drug Discovery, 2021,16(4):331-333.    [ JCR Q1;   中科院 II 区 ]

(7)  C. Xu, S. Guan*, J. Xu, W. Gong, T. Liu, X. Ma, C. Sun, Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel, Carbohydrate Polymers, 2021, 252:117210.     [ JCR Q1;   中科院 I 区 ]

2011-2020 代表性研究文章

[1] T. Liu, J. Zhang*, X. Han, J. Xu, Y. Wu, J. Fang*, Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress, Free Radical Biology & Medicine, 2019, 135:216–226.

[2] Y. Hou, S. Peng, X. Li, J. Yao, J. Xu, J. Fang*, Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2, ACS Chem. Neurosci., 2018, 9(12):3108-3116.

[3] J. Zhang, D. Duan, J. Xu, J. Fang*, Redox-dependent copper carrier promotes cellular copper uptake and oxidative stress-mediated apoptosis of cancer cells, ACS Appl. Mater. Interfaces, 2018, 10(39):33010-33021.

[4] S. Wang, S. Guan*, J. Xu, W. Li, D. Ge, C. Sun, T. Liu, X. Ma, Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering, Biomater. Sci., 2017, 5(10):2024-2034.

[5] J. Xu, Q. Cheng, E.S.J. Arnér*, Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities, Free Radical Biology & Medicine, 2016, 94:110-120. Faculty1000Prime Recommendation 

[6] J. Xu, S. Eriksson, M. Cebula, T. Sandalova, E. Hedström, I. Pader, Q. Cheng, C. Myers, W. Antholine, P. Nagy, U. Hellman, G. Selivanova, Y. Lindqvist, E.S.J. Arnér*, The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death, Cell Death and Disease, 2015, 6:e1616.  Faculty1000Prime Recommendation 

[7] I. Pader#, R. Sengupta#, M. Cebula, J. Xu, J.O. Lundberg, A. Holmgren, K. Johansson, E.S.J. Arnér*, Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase, PNAS, 2014, 111(19):6964-6969.

[8] Y. Shi, F. Nikulenkov, J.Z. Pankau, H. Li, R. Gabdoulline, J. Xu, S. Eriksson, E. Hedström, N. Issaeva, A. Kel, E.S.J. Arnér, G. Selivanova*, ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis, Cell Death & Differentiation, 2014, 21(4):612-623.

[9] S. Iverson, S. Eriksson, J. Xu, P. Justin, T. Emily, T. Mead, E. Mead, M. Capecchi, E.S.J. Arnér, E. Schmidt*, A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage and detoxification, Free Radical Biology & Medicine, 2013, 63:369-380.

[10] R. Engelman, P.W. Shomer, T. Ziv, J. Xu, E.S.J. Arnér, M. Benhar*, Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation, J. Biol. Chem., 2013, 288(16):11312-11324.

[11] M. Dagnell, J. Frijhoff, I. Pader, M. Augsten, B. Boivin, J. Xu, P.K. Mandal, N.K. Tonks, C. Hellberg, M. Conrad, E.S.J. Arnér, A. Ostman*, Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGFβ-receptor tyrosine kinase signaling, PNAS, 2013, 110(33): 13398-13403.

[12] J. Xu, V. Croitoru, D. Rutishauser, Q. Cheng, E.S.J. Arnér*, Wobble decoding by the Escherichia coli selenocysteine insertion machinery, Nucleic Acids Research, 2013, 41(21):9800-9811. 

[13] J. Xu, E.S.J. Arnér*, Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase, Biochemical Pharmacology, 2012, 83:815-820.

[14] X. Peng, J. Xu, E.S.J. Arnér*, Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: Effects related to activity and Sec contents of thioredoxin reductase, Biochem. J., 2012, 447(1):167-174.

[15]  S. P.-Nielsen, T.S. Dexheimer, L. Schultz, W.C. Stafford, Q. Cheng, J. Xu, A. Jadhav, E.S.J. Arnér*, A. Simeonov*, Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay, Free Radical Biology & Medicine, 2011, 50(9):1114-1123.