许建强Jianqiang Xu

(副教授)

 硕士生导师
学位:博士
性别:男
毕业院校:大连理工大学
所在单位:生命科学与药学学院

个人简介

大连理工大学化工学院生物工程系 生物工程学士(大学本科,1998-2002),导师:杨 青 教授

大连理工大学生物科学与技术学院 生物化工博士(提前攻博,2002-2008):导师:杨 青 教授、安利佳 教授。


2005年04月-2005年12月,  Uppsala Universitet (BMC)生物医学中心 访问学者
  导师:Jan-Christer Janson教授(PhD)

2009年02月-2014年09月,  Karolinska Institutet (MBB)医学生物化学 博士后
  导师:Elias S. J. Arner  教授(PhD,MD) 

2014年09月-2020年03月,  大连理工大学生命与医药学院     科研秘书


2015年12月-2019年09月,  大连理工大学生命与医药学院     副教授

2019年09月-至今,        大连理工大学生命科学与药学学院 副教授

 

2015年06月-2017年06月,  大连理工大学盘锦校区科研与学科工作部 部长助理(挂职)


2016年09月-至今          大连理工大学盘锦校区归国华侨联合会 秘书长

2016年03月-2017年12月,  大连理工大学盘锦产业技术研究院 院长助理

2018年01月-至今          大连理工大学盘锦产业技术研究院 副院长

 

学术期刊Current Pharmaceutical Biotechnology   编委              (Editor Board Member, 2018-至今)

学术期刊《精细化工》生物化工方向               编委              (Editor Board Member, 2022-2025)

学术期刊Frontiers in Molecular Biosciences 客座编辑        (Guest Editor,     IF=5.246,2019-2022)

学术期刊Biomedicine & Pharmacotherapy 编委 助理编辑    (Assistant Editor,     IF=7.419,2021-至今)

学术期刊Antioxidants                       客座编辑        (Guest Editor,     IF=7.675,2021-至今

学术期刊IJMS                               客座编辑        (Guest Editor,     IF=6.208,2022-至今

学术期刊Frontiers in Pharmacology            副编辑    (Associate Editor,     IF=5.988,2022-至今

学术期刊Frontiers in Oncology                副编辑    (Associate Editor,     IF=5.738,2022-至今)



担任Signal Transduction and Targeted Therapy、Free Redical Biology & Medicine、Redox Biology、Biochemical Pharmacology、Science of the Total Environment、Biomedicine & Pharmacotherapy、Scientific Reports、Frontiers in Oncology、Frontiers in Pharmacology、Frontiers in Molecular Biosciences、Journal of Nanostructure in Chemistry、Current Medicinal Chemistry、Molecules、Nutrients、Antioxidants、IJMS、Biomedicines、Life、Animals、Current Pharmaceutical Biotechnology、Current Chinese Science、MRMC、BioMed Research International、Disease Markers、Diagnostics、CIMB、Oxidative Medicine and Cellular Longevity等学术刊物特邀审稿人。



中国生物物理学会生物微量元素分会  委员

中国生理学会基质生物学专业委员会  青委 

欧洲自由基生物学与医学学会(SfRBM) 会员(voting member)

盘锦市委市政府科学技术咨询委员会  委员

共青团盘锦市委常委、兼职副书记

大连理工大学盘锦校区侨联秘书长



个人ORCID:   0000-0002-1289-5943

PubMed ID:   58002586

Scopus ID:   48061598700

https://www.researchgate.net/profile/Jianqiang_Xu3

https://loop.frontiersin.org/people/299382/overview

https://

http://faculty.dlut.edu.cn/jianqiang_xu/en/index.htm

https://www.semanticscholar.org/author/Jianqiang-Xu/2754072




2021年以来代表性研究文章

(1)   H. Wang#, S. Sun#, Y. Ren#, R. Yang, Y. Zong, Q. Zhang, J. Zhao, W. Zhang, W. Xu, S. Guan, J. Xu*, Selenite ameliorates cadmium-induced cytotoxicity through down- regulation of ROS levels and up-regulation of selenoprotein thioredoxin reductase 1 in SH-SY5Y cells, Biological Trace Element Research, 2022, in presshttps://doi.org/10.1007/s12011-022-03117-6

(2) Z. Xu, J. Xu, S. Sun, W. Lin, Y. Li, Q. Lu, F. Li, Z. Yang, Y. Lu, W. Liu*, Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma, Redox Biology, 2022, 54:102351.

(3)  Y. Yang#, S. Sun#, W. Xu, Y. Zhang, R. Yang, K. Ma, J. Zhang, J. Xu*, Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin, Antioxidants, 2022, 11:710.

(4)   Y. Zhang#, S. Sun#, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, K. Ma, J. Xu*, Thioredoxin reductase inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling, Free Radical Biology & Medicine, 2022, 180:52-62.

(5)   S. Sun, Y. Zhang, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Zhang, J. Xu*, Plumbagin reduction by thioredoxin reductase 1 possesses synergy effects with GLUT1 Inhibitor on KEAP1-mutant NSCLC cells, Biomedicine & Pharmacotherapy, 2022, 146(33):112546.

(6)   S. Sun, Y. Zhang, W. Xu, Y. Zhang, R. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Xu*, Chlorophyllin inhibits mammalian thioredoxin reductase 1 and triggers cancer cell death, Antioxidants, 2021, 10:1733.

(7)   S. Sun#, W. Xu#, Y. Zhang, Y. Yang, Q. Ma*, J. Xu*, Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution. Free Radical Biology & Medicine, 2021, 172:482-489.

(8)   K. Ma#, W. Li#, G. Zhu, S. Sun, H. Chi, Y. Yin, H. Diao, X. Xing, Z. Guo, L. Wang, W. Xu, C. Cui, J. Xu*. Functionalized PDA/DEX-PEI@HA nanoparticles combined with sleeping- beauty transposons for multistage targeted delivery of CRISPR/Cas9 gene, Biomedicine & Pharmacotherapy, 2021, 142:112061.

(9)   S. Sun#, W. Xu#, H. Zhou, Y. Zhang, J. Zhang, X. Li, B. Li, K. Ma, J. Xu*, Efficient purification of selenoprotein thioredoxin reductase 1 by using chelating reagents to protect the affinity resins and rescue the enzyme activities, Process Biochemistry, 2021, 101:256-265.

(10)   K. Ma#, W. Li#, G. Zhu, H. Chi, Y. Yin, Y. Li, Y. Zong, Z. Guo, L. Wang, W. Xu, C. Cui, H. Zhou, J. Xu*, PEGylated DOX-coated nano graphene oxide as pH-responsive multifunctional nanocarrier for targeted drug delivery, Journal of Drug Targeting, 2021, 29(8):884-891.

(11) J. Xu, J. Fang*, How can we improve the design of small molecules to target thioredoxin reductase for treating cancer? Expert Opinion on Drug Discovery, 2021,16(4):331-333. 

(12)  C. Xu, S. Guan*, J. Xu, W. Gong, T. Liu, X. Ma, C. Sun, Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel, Carbohydrate Polymers, 2021, 252:117210.  






2021年以前代表性研究文章

[1] T. Liu, J. Zhang*, X. Han, J. Xu, Y. Wu, J. Fang*, Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress, Free Radical Biology & Medicine, 2019, 135:216–226.

[2]  J. Yao, S. Peng, J. Xu, J. Fang*, Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway, Biofactors, 2019, 45(4):616-626.

[3] Y. Hou, S. Peng, X. Li, J. Yao, J. Xu, J. Fang*, Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2, ACS Chem. Neurosci., 2018, 9(12):3108-3116.

[4] J. Zhang, D. Duan, J. Xu, J. Fang*, Redox-dependent copper carrier promotes cellular copper uptake and oxidative stress-mediated apoptosis of cancer cells, ACS Appl. Mater. Interfaces, 2018, 10(39):33010-33021.

[5] S. Wang, S. Guan*, J. Xu, W. Li, D. Ge, C. Sun, T. Liu, X. Ma, Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering, Biomater. Sci., 2017, 5(10):2024-2034.

[6] J. Xu, Q. Cheng, E.S.J. Arnér*, Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities, Free Radical Biology & Medicine, 2016, 94:110-120.                         Faculty1000Prime recommended 

[7] S. Guan*, J. Xu, Y. Guo, D. Ge, T. Liu, X. Ma, Z. Cui, Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells, Int. J. Dev. Neurosci., 2015, 42:37-45.

[8] J. Xu, S. Eriksson, M. Cebula, T. Sandalova, E. Hedström, I. Pader, Q. Cheng, C. Myers, W. Antholine, P. Nagy, U. Hellman, G. Selivanova, Y. Lindqvist, E.S.J. Arnér*, The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death, Cell Death and Disease, 2015, 6:e1616.                   Faculty1000Prime recommended 

[9] I. Pader#, R. Sengupta#, M. Cebula, J. Xu, J.O. Lundberg, A. Holmgren, K. Johansson, E.S.J. Arnér*, Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase, PNAS, 2014, 111(19):6964-6969.

[10Y. Shi, F. Nikulenkov, J.Z. Pankau, H. Li, R. Gabdoulline, J. Xu, S. Eriksson, E. Hedström, N. Issaeva, A. Kel, E.S.J. Arnér, G. Selivanova*, ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis, Cell Death & Differentiation, 2014, 21(4):612-623.

[11] S. Iverson, S. Eriksson, J. Xu, P. Justin, T. Emily, T. Mead, E. Mead, M. Capecchi, E.S.J. Arnér, E. Schmidt*, A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage and detoxification, Free Radical Biology & Medicine, 2013, 63:369-380.

[12] R. Engelman, P.W. Shomer, T. Ziv, J. Xu, E.S.J. Arnér, M. Benhar*, Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation, J. Biol. Chem., 2013, 288(16):11312-11324.

[13] M. Dagnell, J. Frijhoff, I. Pader, M. Augsten, B. Boivin, J. Xu, P.K. Mandal, N.K. Tonks, C. Hellberg, M. Conrad, E.S.J. Arnér, A. Ostman*, Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGFβ-receptor tyrosine kinase signaling, PNAS, 2013, 110(33):13398-13403.

[14] J. Xu, V. Croitoru, D. Rutishauser, Q. Cheng, E.S.J. Arnér*, Wobble decoding by the Escherichia coli selenocysteine insertion machinery, Nucleic Acids Research, 2013, 41(21):9800-9811. 

[15] J. Xu, E.S.J. Arnér*, Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase, Biochemical Pharmacology, 2012, 83:815-820.

[16] X. Peng, J. Xu, E.S.J. Arnér*, Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: Effects related to activity and Sec contents of thioredoxin reductase, Biochem. J., 2012, 447(1):167-174.

[17]  S. P.-Nielsen, T.S. Dexheimer, L. Schultz, W.C. Stafford, Q. Cheng, J. Xu, A. Jadhav, E.S.J. Arnér*, A. Simeonov*, Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay, Free Radical Biology & Medicine, 2011, 50(9):1114-1123.



教育经历

[1] 2002.9-2008.10
大连理工大学 | 生物化工 | 博士
[2] 1998.9-2002.7
大连理工大学 | 生物工程 | 学士
[3] 1995.9-1998.7
长庆油田长庆一中

工作经历

[1] 2014.9-至今
School of Life & Pharmaceutical Sciences (LPS) | 大连理工大学  | 讲师 
[2] 2009.2-2014.9
Medical Biochemistry & Biophysics (MBB) | 瑞典卡罗林斯卡医学院  | 博士后 
[3] 2005.4-2005.12
Uppsala Biomedical Centrum (BMC) | 瑞典乌普萨拉大学  | 中瑞政府间合作项目 

研究方向

[1]

  1. 硒蛋白与程序性细胞死亡

  2. 硒酶掺硒机制及生物合成

  3. 肿瘤耐药性克服与新机制

  4. 硒蛋白糖基化修饰和性质

  5. 海洋富硒养殖和功能食品


社会兼职

[1]2021.1-2022.3
特刊编辑(国际刊物 Frontiers in Molecular Biosciences)
[2]2021.5-2024.5
助理编辑(国际刊物 Biomedicine & Pharmacotherapy (IF 5.0))
[3]2021.1-2022.3
国际编委(国际刊物Current Chinese Science)
[4]2021.5-2024.5
Assistant Editor 助理编辑(Biomedicine&Pharmacotherapy 学术期刊 属于Elsevier出版集团)

团队成员