王磊

基本信息Personal Information

副教授

性别:男

毕业院校:北海道大学

学位:博士

在职信息:在职

所在单位:化工学院

学科:药物化学 化学生物学 有机化学

办公地点:大连理工大学西部校区化工实验楼G206

联系方式:leiwang@dlut.edu.cn

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王磊,博士,副教授

教育背景及工作经历:

2006.09—2010.07   大连理工大学,化工学院,制药工程,学士

2010.09—2011.09   大连理工大学,制药科学与技术学院,药物化学,硕士

2011.10—2013.09   日本北海道大学,农学部,应用生物科学,硕士

2013.10—2016.09   日本北海道大学,农学部,应用生物科学,博士

2016.10—2019.03   美国明尼苏达大学双城分校,药物设计中心,博士后

2019.03—至今  大连理工大学,化工学院药学系,副教授


从事药物化学,化学生物学,有机化学等领域的研究工作,现已在Angew. Chem. Int. Ed.Org. Lett.Eur. J. Med. Chem.; J. Org. Chem.; Eur. J. Org. Chem.等杂志发表学术论文二十多篇。


研究方向: 

1 多功能小分子光亲和标记探针的研究。 

2 抗病毒(HIV-1, HCMV)抑制剂的设计,合成及活性评估。 

3 新型有氧氧化反应的开发。


https://orcid.org/0000-0001-6915-2713


代表性成果: 

1. Lei Wang, Jing Tang, Andrew Huber, Mary Casey, Karen A. Kirby, Daniel J. Wilson, Jayakanth Kankanala, Jiashu Xie, Michael A. Parniak, Stefan G. Sarafianos and Zhengqiang Wang*. 6-Arylthio-3-hydroxypyrimidine-2,4-diones Potently Inhibited HIV Reverse Transcriptase-associated RNase H with Antiviral Activity. Eur. J. Med. Chem2018156. 652 – 665. (TOP 2 Research Journal in CHEMISTRY, MEDICINAL)

2. Lei Wang, Jing Tang, Andrew Huber, Mary Casey, Karen A. Kirby, Daniel J. Wilson, Jayakanth Kankanala, Michael A. Parniak, Stefan G. Sarafianos and Zhengqiang Wang*. 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. Eur. J. Med. Chem2018., 156. 680 – 691. (TOP 2 Research Journal in CHEMISTRY, MEDICINAL)

3. Lei Wang,* Akiko Ishida, Yasuyuki Hashidoko, and Makoto Hashimoto*. Dehydrogenation of the NH-NH Bond Triggered by Potassium tert-Butoxide in Liquid Ammonia. Angew. Chem. Int. Ed201756, 870 – 873. 

4. Lei Wang,* Yasuyuki Hashidoko, and Makoto Hashimoto*. Cosolvent-Promoted O-Benzylation with Silver(I) Oxide: Synthesis of 1'-Benzylated Sucrose Derivatives, Mechanistic Studies, and Scope Investigation. J. Org. Chem201681, 4464 – 4474. 

5. Lei Wang, Takuma Yoshida, Yasuyuki Muto, Yuta Murai, Zetryana Puteri Tachrim, Akiko Ishida, Shiori Nakagawa, Yasuko Sakihama, Yasuyuki Hashidoko, Katsuyoshi Masuda, Yasumaru Hatanaka, and Makoto Hashimoto*. Synthesis of Diazirine-Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling of Gustatory Receptors. Eur. J. Org. Chem201514, 3129 – 3134.

6. Lei Wang, Yuta Murai, Takuma Yoshida, Akiko Ishida, Katsuyoshi Masuda, Yasuko Sakihama, Yasuyuki Hashidoko, Yasumaru Hatanaka, and Makoto Hashimoto*. Alternative One-Pot Synthesis of (Trifluoromethyl)phenyldiazirines from Tosyloxime Derivatives: Application for New Synthesis of Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling. Org. Lett201517, 616 – 619. 


  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 社会兼职Social Affiliations