李海东，博士，副教授，硕士生导师，2013年于兰州大学取得学士学位，2019年4月于大连理工大学精细化工国家重点实验室取得博士学位。2019年6月-2021年9月在韩国梨花女子大学Juyoung Yoon院士课题组开展博士后研究工作。2021年10月加入大连理工大学生物工程学院工作，主要从事智能分子前药、功能性荧光探针研制及其在疾病诊疗中的应用研究，相关成果以第一作者/通讯作者在Chem. Soc. Rev., Coord. Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Drug. Deliv. Rev. CCS Chem., Biomaterials, Chem. Sci., Aggregate, Samll Methods等国际期刊发表学术论文25余篇，申请/授权发明专利10/5项。担任Sci. Adv., ACS Nano, Small等国际期刊审稿人。

研究方向：

1.  开发智能分子前药用于肿瘤化疗免疫治疗；

2.  构筑酶激活生物荧光探针用于重大疾病的早期诊断；

3.  设计多模态活体肿瘤成像用生物荧光探针；

4.  制备抗病毒和耐药性细菌生物凝胶材料。

欢迎具有生物、化学、材料、医学背景的同学加入课题组攻读硕士、博士学位，有意者请发送简历至lihd@dlut.edu.cn，期待您的加入！同时，也欢迎本科生来课题组开展大创和毕业设计。

代表性文章：

28. Yves S. Kafuti,^# Shuang Zeng,^# Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon*, Haidong Li*. Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe. Chem. Commun., 2023, 59, 2493-2496. 

27. Jingjing Han,^# Shuang Zeng,^# Yahui Chen, Haidong Li*, Juyoung Yoon*. Prospects of coupled iron-based nanostrctures in preclinical antibacterial therapy. Adv. Drug. Deliv. Rev., 2023, 193, 114672.

26. Mengyao Yang,^# Cheng Zhang,^# Rui Wang, Xiaofeng Wu, Haidong Li*, Juyoung Yoon*. Cancer immunotherapy elicited by immunogenic cell death based on smart nanomaterials. Small Methods, 2023, 2201381.

25. Haidong Li,* Heejeong Kim, Cheng Zhang, Shuang Zeng, Qixian Chen, Lingyun Jia, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon*. Mitochondrial-targeted smart AIEgens: imaging and therapeutics. Coord. Chem. Rev., 2022, 473, 214818.

24. Hua Gu, Weijing Liu, Haidong Li, Wen Sun, Jianjun Du, Jiangli Fan*, Xiaojun Peng. 2,1,3-Benzothiadiazole derivative AIEgens for smart phototheranostics. Coord. Chem. Rev., 2022, 473, 214803.

23. Xiaosheng Liu,^# Shuang Zeng,^# Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon*, Haidong Li*. Monitoring mitochondrial nitroreductase activity in tumors and hind limb ischemic mice model using a novel activatable NIR fluorescent probe. Chem. Commun., 2022, 58, 11438-11441.

22. Shuang Zeng,^# Zuokai Wang,^# Chen Chen, Xiaosheng Liu, Yu Wang, Qixian Chen, Jingyun Wang*, Haidong Li*, Xiaojun Peng, Juyoung Yoon*. Construction of rhodamine-based AIE photosensitizer hydrogel with clinical potential for selective ablation of drug-resistant gram-positive bacteria in vivo. Adv. Healthc. Mater., 2022, 11, 2200837.

21. Jingjing Han,^# Haidong Li (co-first author),^# Luyang Zhao,^# Gyoungmi Kim, Yahui Chen, Xuehai Yan*, Juyoung Yoon*. Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy. Chem. Sci., 2022, 13, 7814-7820.

20. Haidong Li,^# Mengyao Yang,^# Ji Seon Kim,^# Jeongsun Ha, Jingjing Han, Heejeong Kim, Yejin Cho, Jingyun Wang, Ki Taek Nam*, Juyoung Yoon*. Structure-oriented design strategy to construct NIR AIEgens to selectively combate gram (+) multidrug-resistant bacteria in vivo. Biomaterials, 2022, 286, 121580.

19. Haidong Li,^# Heejeong Kim,^# Feng Xu, Jingjing Han, Qichao Yao, Jingyun Wang, Kanyi Pu*, Xiaojun Peng*,Juyoung Yoon*.Activity-based NIR fluorescent probes based on versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook. Chem. Soc. Rev., 2022, 51, 1795-1835. (ESI highly cited & ESI hot)

18. Qichao Yao, Jiangli Fan*, Saran Long, Xueze Zhao, Haidong Li, Jianjun Du, Kun Shao, Xiaojun Peng*.  The concept and examples of type-III photosensitizers for cancer photodynamic therapy. Chem, 2022. 8, 197-209. (ESI highly cited)

17. Jingjing Han,^# Hyo Won Lee,^# Yahui Chen,  Haidong Li*, Hwan Myung Kim*, Juyoung Yoon*. Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe. Mater. Chem. Front., 2022, 6, 553-560. (2022 Materials Chemistry Frontiers HOT articles)

16. Jingjing Han, Haidong Li, Juyoung Yoon*. Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment. Nano Today, 2022, 43, 101392.

15. Haidong Li,^# Liuwei Zhang,^# Jingjing Han,^# Dayeh Kim,^# Heejeong Kim, Jeongsun Ha, Jingyun Wang*, Juyoung Yoon*. CCS Chem., 2022, 4, 487-500. (CCS flagship publication)

14. Haidong Li, Dayeh Kim, Qichao Yao, Haoying Ge, Jeewon Chung, Jiangli Fan, Jingyun Wang, Xiaojun Peng*, Juyoung Yoon*. Activity-Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image-Guided Surgery. Angew. Chem. Int. Ed., 2021, 60, 17268-17289. (ESI highly cited and ESI hot)

13. Haidong Li,^# Yang Lu,^# Jeewon Chung, Jingjing Han, Heejeong Kim, Qichao Yao, Gyoungmi Kim, Xiaofeng Wu, Saran Long, Xiaojun Peng*, Juyoung Yoon*. Activation of Apoptosis by Rationally Constructing NIR Amphiphilic AIEgens: Surmounting the Shackle of Mitochondrial Membrane Potential for Amplified Tumor Ablation. Chem. Sci., 2021, 12, 10522-10531. (Most popular 2021 analytical chemistry articles)

12. Haidong Li, Heejeong Kim, Jingjing Han, Van-Nghia Nguyen, Xiaojun Peng* Juyoung Yoon*. Activity-Based Smart AIEgens for Detection, Bioimaging, and Therapeutics: Recent Progress and Outlook. Aggregate 2021, 2, e51. (Selected as Inside Back Cover and the 2021-2022 Best Paper Award)

11. Haidong Li,^# Qichao Yao,^# Zhongji Pu, Jeewon Chung, Haoying Ge, Chao Shi, Ning Xu, Feng Xu, Wen Sun, Jianjun Du, Jiangli Fan, Jingyun Wang, Juyoung Yoon,* Xiaojun Peng*. Hypoxia-Activatable Nano-prodrug for Fluorescently Tracking Drug in Mice. Sci. CHINA Chem., 2021, 64, 499-508.

10. Haidong Li, Qichao Yao, Wen Sun, Kun Shao, Yang Lu, Jeewon Chung, Dayeh Kim, Jiangli Fan, Saran Long, Jianjun Du, Yueqing Li, Jingyun Wang, Juyoung Yoon*, Xiaojun Peng*. Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying. J. Am. Chem. Soc., 2020, 142, 6381-6389. (ESI highly cited).

9. Haidong Li,^# Qichao Yao,^# Feng Xu,^# Yueqing Li, Dayeh Kim, Jeewon Chung, Gain Baek, Xiaofeng Wu, Prima Fitria Hillman, Eun Young Lee, Haoying Ge, Jiangli Fan, Jingyun Wang, Sang-Jip Nam, Xiaojun Peng*, Juyoung Yoon*. An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision. Angew. Chem. Int. Ed., 2020, 59, 10186-10195.

8. Xiaofeng Wu, Haidong Li, Eunhye Lee, Juyoung Yoon*. Sensors for in situ real-time fluorescence imaging of enzymes. Chem, 2020, 6, 2893-2901.

7. Xiao Zhou, Haidong Li, Chao Shi, Feng Xu, Zhen Zhang, Qichao Yao, He Ma, Wen Sun, Kun Shao, Jianjun Du, Saran Long,* Jiangli Fan, Jingyun Wang, Xiaojun Peng*. Biomaterials, 2020, 253, 120089.

6. Haidong Li, Yueqing Li, Qichao Yao, Jiangli Fan*, Wen Sun, Saran Long, Kun Shao, Jianjun Du, Jingyun Wang, Xiaojun Peng. In Situ Imaging of Aminopeptidase N Activity in Hepatocellular Carcinoma: a Migration Model for Tumour using an Activatable Two-Photon NIR Fluorescent Probe. Chem. Sci., 2019, 10, 1619-1625. (Near-infrared (NIR) luminescent probes for bioimaging and biosensing, Most popular 2019-2020 chemical biology articles and 2018 Chemical Science HOT Article Collection)

5. Feng Xu, Haidong Li, Qichao Yao, Haoying Ge, Jiangli Fan, Wen Sun, Jingyun Wang, Xiaojun Peng*. Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy. Chem. Sci., 2019, 10, 10586-10594. 

4. Liman Xian, Feng Xu, Jianzhou Liu, Haidong Li, Haoying Ge, Kun Shao, Jiangli Fan, Guishan Xiao*, Xiaojun Peng*. MicroRNA detection with turnover amplification via hybridization-mediated staudinger reduction for pancreatic cancer diagnosis. J. Am. Chem. Soc., 2019, 141, 20190-20497.

3. Haidong Li, Qichao Yao, Feng Xu, Ning Xu, Ran Duan, Saran Long, Jiangli Fan, Jianjun Du, Jingyun Wang, Xiaojun Peng*. Imaging γ-Glutamyltranspeptidase for Tumor Identification and Resection Guidance via Enzyme-Triggered Fluorescent Probe. Biomaterials, 2018, 179, 1-14.

2. Qichao Yao, Haidong Li, Liman Xian, Feng Xu, Jing Xia, Jiangli Fan*, Jianjun Du, Jingyun Wang, Xiaojun Peng. Differentiating RNA from DNA by a molecular fluorescent probe based on the “door-bolt” mechanism biomaterials. Biomaterials, 2018, 177, 78-87.

1. Haidong Li, Qichao Yao, Jiangli Fan, Jianjun Du, Jingyun Wang, Xiaojun Peng*. A Two-photon NIR-to-NIR Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells. Biosens. Bioelectron., 2017, 94, 536-543.

发明专利：

10. 樊江莉, 姚起超, 李海东, 边雅娜, 李明乐, 王静云, 彭孝军, オキサジン系化合物およびその使用, 专利号: 2021-510504.

9.  彭孝军, 李海东, 姚起超, 樊江莉, 杜健军, 半菁类荧光染料, 专利号: ZL 201610343736.8.

8.  彭孝军, 姚起超, 李海东, 樊江莉, 王静云, 噁嗪类化合物在制备近红外荧光探针中的应用, 专利号: ZL 201610983551.3.

7.  彭孝军, 李海东, 姚起超, 樊江莉, 杜健军, 荧光探针及其制备方法和用途, 专利号: ZL 201710895827.7.

6.  樊江莉, 姚起超, 李海东, 边雅娜, 李明乐, 王静云, 彭孝军, 噁嗪类化合物及其应用, 专利号: ZL 201810420618.1.

5.  Juyoung Yoon, Haidong Li, et al. P2021-0158KR.

4.  Juyoung Yoon, Haidong Li, et al. P2020-0258KR.

3.  Juyoung Yoon, Haidong Li, et al. P2020-0247KR.

2.  Juyoung Yoon, Haidong Li, et al. P2022-0044KR.

1. 王静云, 曾爽, 刘晓胜, 李海东, 陈麒先, 用于革兰氏阳性菌选择性杀伤的基于罗丹明的AIE光敏剂及凝胶敷料制备方法和应用,CN114890976A.