李海东

个人信息Personal Information

副教授

硕士生导师

主要任职:Associate Professor

性别:男

毕业院校:大连理工大学

学位:博士

所在单位:生物工程学院

办公地点:生物工程学院509

联系方式:lihd@dlut.edu.cn

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个人简介Personal Profile

李海东,博士,副教授,2013年于兰州大学取得学士学位,2019于大连理工大学精细化工国家重点实验室取得博士学位。2019-2021在韩国梨花女子大学Juyoung Yoon院士课题组开展博士后研究工作。2021年加入大连理工大学开展教学科研工作,主要从事智能分子前药/染料、荧光探针结构创制及生物医学应用研究,相关成果以第一(共一)/通讯作者在J. Am. Chem. Soc. (1), Angew. Chem. Int. Ed(5) CCS Chem. (1)Chem. Soc. Rev. (2), Coord. Chem. Rev(2) Biomaterials (2), Chem. Sci. (3), Aggregate (1)等国际期刊发表学术论文30篇(影响因子≥10论文18篇,3篇入选ESI热点论文7篇入选ESI高被引论文),主持国家自然科学基金面上项目、辽宁省科技计划联合计划(应用基础研究)等项目申请/授权发明专利15/8,受邀担任辽宁省细胞生物学会妇科肿瘤创新转化专业委员会副主任委员、精细化工青年委员会委员、Molecules期刊编委及Sci. Adv.ACS Nano等国际期刊审稿人。

研究方向

1.  创制智能染料分子用于肿瘤免疫治疗;

2.  构筑酶激活生物荧光探针用于重大疾病的早期诊断;

3.  制备抗耐药性细菌生物医用材料

欢迎具有化学、生物、材料背景的同学加入课题组攻读硕士、博士学位,有意者请发送简历至lihd@dlut.edu.cn,期待您的加入!

代表性文章

34. Shuang Zeng, Yang Wang, Chen Chen, Heejeong Kim, Xiaosheng Liu, Maojun Jiang, Yichu Yu, Yves S. Kafuti, Qixian Chen, Jingyun Wang*, Xiaojun Peng, Haidong Li*, Juyoung Yoon*, Angew. Chem. Int. Ed.2024, 63, e202316487.

33. Shuang Zeng,# Zhihan Guo,# Yifu Hao,# Yves S. Kafuti,# Zhuo Yang, Qichao Yao, Jingyun Wang*, Xiaojun Peng, Haidong Li*Coord. Chem. Rev.2024, 509, 215786.

32. Yumei Wang,# Cheng Zhang,# Lei Hao,# Xiaoli Huo, Linqiang Dou, Jingyun Wang*, Xiaojun Peng, Haidong Li*, Dyes Pigments, 2024, 224, 112026.

31. Haidong Li, Jingyun Wang, Heejeong Kim, Xiaojun Peng*, Juyoung Yoon*, Angew. Chem. Int. Ed.2024, 63, e202311764.

30. Haoran Zheng,# Haidong Li (co-first author),# Mingqiang Li,# Tingting Zhai, Xiaodong Xie, Cong Li, Xinxin Jing, Chengpin Liang, Qian Li, Xiaolei Zuo, Jiang Li, Jiangli Fan*, Jianlei Shen*, Xiaojun Peng, Chunhai Fan, A Membrane Tension-Responsive Mechanosensitive DNA Nanomachine, Angew. Chem. Int. Ed., 2023, 62, e202305896.

29. Shuang Zeng,# Xiaosheng Liu,# Yves S. Kafuti,# Heejeong Kim, Jingyun Wang*, Xiaojun Peng*, Haidong Li*, Juyoung Yoon*, Fluorescent Dyes Based on Rhodamine Derivatives for Bioimaging and Therapeutics: Recent Progresses, Challenges, and Prospects. Chem. Soc. Rev., 2023, 52, 5607-5651. (ESI highly cited and ESI hot)

28. Yves S. Kafuti,# Shuang Zeng,# Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon*, Haidong Li*. Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe. Chem. Commun., 2023, 59, 2493-2496. (ChemComm Most Popular 2023 Articles)

27. Jingjing Han,# Shuang Zeng,# Yahui Chen, Haidong Li*, Juyoung Yoon*. Prospects of coupled iron-based nanostrctures in preclinical antibacterial therapy. Adv. Drug. Deliv. Rev., 2023, 193, 114672. (ESI highly cited)

26. Mengyao Yang,# Cheng Zhang,# Rui Wang, Xiaofeng Wu, Haidong Li*, Juyoung Yoon*. Cancer immunotherapy elicited by immunogenic cell death based on smart nanomaterials. Small Methods, 2023, 7, 2201381. (Selected as Inside Front Cover)

25. Haidong Li,* Heejeong Kim, Cheng Zhang, Shuang Zeng, Qixian Chen, Lingyun Jia, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon*. Mitochondrial-targeted smart AIEgens: imaging and therapeutics. Coord. Chem. Rev., 2022, 473, 214818. (ESI highly cited)

24. Hua Gu, Weijing Liu, Haidong Li, Wen Sun, Jianjun Du, Jiangli Fan*, Xiaojun Peng. 2,1,3-Benzothiadiazole derivative AIEgens for smart phototheranostics. Coord. Chem. Rev., 2022, 473, 214803.

23. Xiaosheng Liu,# Shuang Zeng,# Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang,* Xiaojun Peng, Juyoung Yoon*, Haidong Li*. Monitoring mitochondrial nitroreductase activity in tumors and hind limb ischemic mice model using a novel activatable NIR fluorescent probe. Chem. Commun., 2022, 58, 11438-11441.

22. Shuang Zeng,# Zuokai Wang,# Chen Chen, Xiaosheng Liu, Yu Wang, Qixian Chen, Jingyun Wang*, Haidong Li*, Xiaojun Peng, Juyoung Yoon*. Construction of rhodamine-based AIE photosensitizer hydrogel with clinical potential for selective ablation of drug-resistant gram-positive bacteria in vivo. Adv. Healthc. Mater., 2022, 11, 2200837.

21. Jingjing Han,# Haidong Li (co-first author),# Luyang Zhao,# Gyoungmi Kim, Yahui Chen, Xuehai Yan*, Juyoung Yoon*. Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy. Chem. Sci., 2022, 13, 7814-7820.

20. Haidong Li,# Mengyao Yang,# Ji Seon Kim,# Jeongsun Ha, Jingjing Han, Heejeong Kim, Yejin Cho, Jingyun Wang, Ki Taek Nam*, Juyoung Yoon*. Structure-oriented design strategy to construct NIR AIEgens to selectively combate gram (+) multidrug-resistant bacteria in vivo. Biomaterials, 2022, 286, 121580.

19. Haidong Li,# Heejeong Kim,# Feng Xu, Jingjing Han, Qichao Yao, Jingyun Wang, Kanyi Pu*, Xiaojun Peng*,Juyoung Yoon*.Activity-based NIR fluorescent probes based on versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook. Chem. Soc. Rev., 2022, 51, 1795-1835. (ESI highly cited & ESI hot)

18. Qichao Yao, Jiangli Fan*, Saran Long, Xueze Zhao, Haidong Li, Jianjun Du, Kun Shao, Xiaojun Peng*.  The concept and examples of type-III photosensitizers for cancer photodynamic therapy. Chem, 2022. 8, 197-209. (ESI highly cited)

17. Jingjing Han,# Hyo Won Lee,# Yahui Chen,  Haidong Li*, Hwan Myung Kim*, Juyoung Yoon*. Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe. Mater. Chem. Front.2022, 6, 553-560. (2022 Materials Chemistry Frontiers HOT articles)

16. Jingjing Han, Haidong Li, Juyoung Yoon*. Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment. Nano Today2022, 43, 101392.

15. Haidong Li,# Liuwei Zhang,# Jingjing Han,# Dayeh Kim,# Heejeong Kim, Jeongsun Ha, Jingyun Wang*, Juyoung Yoon*. CCS Chem.2022, 4, 487-500. (CCS flagship publication)

14. Haidong Li, Dayeh Kim, Qichao Yao, Haoying Ge, Jeewon Chung, Jiangli Fan, Jingyun Wang, Xiaojun Peng*, Juyoung Yoon*. Activity-Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image-Guided Surgery. Angew. Chem. Int. Ed.2021, 60, 17268-17289. (ESI highly cited and ESI hot)

13. Haidong Li,# Yang Lu,# Jeewon Chung, Jingjing Han, Heejeong Kim, Qichao Yao, Gyoungmi Kim, Xiaofeng Wu, Saran Long, Xiaojun Peng*, Juyoung Yoon*. Activation of Apoptosis by Rationally Constructing NIR Amphiphilic AIEgens: Surmounting the Shackle of Mitochondrial Membrane Potential for Amplified Tumor Ablation. Chem. Sci., 2021, 12, 10522-10531. (Most popular 2021 analytical chemistry articles)

12. Haidong Li, Heejeong Kim, Jingjing Han, Van-Nghia Nguyen, Xiaojun Peng* Juyoung Yoon*. Activity-Based Smart AIEgens for Detection, Bioimaging, and Therapeutics: Recent Progress and Outlook. Aggregate 2021, 2, e51. (Selected as Inside Back Cover and the 2021-2022 Best Paper Award)

11. Haidong Li,# Qichao Yao,# Zhongji Pu, Jeewon Chung, Haoying Ge, Chao Shi, Ning Xu, Feng Xu, Wen Sun, Jianjun Du, Jiangli Fan, Jingyun Wang, Juyoung Yoon,* Xiaojun Peng*. Hypoxia-Activatable Nano-prodrug for Fluorescently Tracking Drug in Mice. Sci. CHINA Chem., 2021, 64, 499-508.

10. Haidong Li, Qichao Yao, Wen Sun, Kun Shao, Yang Lu, Jeewon Chung, Dayeh Kim, Jiangli Fan, Saran Long, Jianjun Du, Yueqing Li, Jingyun Wang, Juyoung Yoon*, Xiaojun Peng*. Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying. J. Am. Chem. Soc., 2020, 142, 6381-6389. (ESI highly cited).

9. Haidong Li,# Qichao Yao,# Feng Xu,# Yueqing Li, Dayeh Kim, Jeewon Chung, Gain Baek, Xiaofeng Wu, Prima Fitria Hillman, Eun Young Lee, Haoying Ge, Jiangli Fan, Jingyun Wang, Sang-Jip Nam, Xiaojun Peng*, Juyoung Yoon*. An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision. Angew. Chem. Int. Ed., 2020, 59, 10186-10195. (ESI highly cited)

8. Xiaofeng Wu, Haidong Li, Eunhye Lee, Juyoung Yoon*. Sensors for in situ real-time fluorescence imaging of enzymes. Chem, 2020, 6, 2893-2901.

7. Xiao Zhou, Haidong Li, Chao Shi, Feng Xu, Zhen Zhang, Qichao Yao, He Ma, Wen Sun, Kun Shao, Jianjun Du, Saran Long,* Jiangli Fan, Jingyun Wang, Xiaojun Peng*. Biomaterials, 2020, 253, 120089.

6. Haidong Li, Yueqing Li, Qichao Yao, Jiangli Fan*, Wen Sun, Saran Long, Kun Shao, Jianjun Du, Jingyun Wang, Xiaojun Peng. In Situ Imaging of Aminopeptidase N Activity in Hepatocellular Carcinoma: a Migration Model for Tumour using an Activatable Two-Photon NIR Fluorescent Probe. Chem. Sci., 2019, 10, 1619-1625. (Near-infrared (NIR) luminescent probes for bioimaging and biosensing, Most popular 2019-2020 chemical biology articles and 2018 Chemical Science HOT Article Collection)

5. Feng Xu, Haidong Li, Qichao Yao, Haoying Ge, Jiangli Fan, Wen Sun, Jingyun Wang, Xiaojun Peng*. Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy. Chem. Sci., 2019, 10, 10586-10594. 

4. Liman Xian, Feng Xu, Jianzhou Liu, Haidong Li, Haoying Ge, Kun Shao, Jiangli Fan, Guishan Xiao*, Xiaojun Peng*. MicroRNA detection with turnover amplification via hybridization-mediated staudinger reduction for pancreatic cancer diagnosis. J. Am. Chem. Soc., 2019, 141, 20190-20497.

3. Haidong Li, Qichao Yao, Feng Xu, Ning Xu, Ran Duan, Saran Long, Jiangli Fan, Jianjun Du, Jingyun Wang, Xiaojun Peng*. Imaging γ-Glutamyltranspeptidase for Tumor Identification and Resection Guidance via Enzyme-Triggered Fluorescent Probe. Biomaterials, 2018, 179, 1-14.

2. Qichao Yao, Haidong Li, Liman Xian, Feng Xu, Jing Xia, Jiangli Fan*, Jianjun Du, Jingyun Wang, Xiaojun Peng. Differentiating RNA from DNA by a molecular fluorescent probe based on the “door-bolt” mechanism biomaterials. Biomaterials, 2018, 177, 78-87.

1. Haidong Li, Qichao Yao, Jiangli Fan, Jianjun Du, Jingyun Wang, Xiaojun Peng*. A Two-photon NIR-to-NIR Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells. Biosens. Bioelectron., 2017, 94, 536-543.

发明专利:

15. 李海东,张程,王静云,殷晓兰,郝磊,彭孝军,中国发明专利,202410647378.4.

14. 李海东,郝磊,王静云,张程,彭孝军,中国发明专利,202410274086.0.

13. 李海东,曾爽,王静云,刘晓胜,陈晨,彭孝军,中国发明专利,202410155352.8.

12. 李海东,王玉美,王静云,张程,郝磊,中国发明专利,202410045332.5.

11. Jiangli Fan, Qichao Yao, Haidong Li, Yana Bian, Mingle Li, Jingyun Wang, Xiaojun Peng, Oxazine Compound and Application Thereof. US11639360B2.

10. 樊江莉,姚起超,李海东,边雅娜,李明乐,王静云,彭孝军, オキサジン系化合物およびその使用,专利号: 2021-510504.

9.  彭孝军,李海东,姚起超,樊江莉,杜健军,半菁类荧光染料,专利号: ZL201610343736.8.

8.  彭孝军,姚起超,李海东,樊江莉,王静云,噁嗪类化合物在制备近红外荧光探针中的应用,专利号: ZL 201610983551.3.

7.  彭孝军,李海东,姚起超,樊江莉,杜健军,荧光探针及其制备方法和用途,专利号: ZL201710895827.7.

6.  樊江莉,姚起超,李海东,边雅娜,李明乐,王静云,彭孝军,噁嗪类化合物及其应用,专利号: ZL201810420618.1.

5.  Juyoung Yoon, Haidong Li, et al. P2021-0158KR.

4.  Juyoung Yoon, Haidong Li, et al. P2020-0258KR.

3.  Juyoung Yoon, Haidong Li, et al. P2020-0247KR.

2.  Juyoung Yoon, Haidong Li, et al. P2022-0044KR.

1. 王静云,曾爽,刘晓胜,李海东,陈麒先,用于革兰氏阳性菌选择性杀伤的基于罗丹明的AIE光敏剂及凝胶敷料制备方法和应用,专利号: ZL202210194779.X.


  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 社会兼职Social Affiliations