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  刘书馨，女，中共党员，1997年毕业于中国医科大学临床医学系，2003年获大连医科大学肾脏病学硕士学位，2007年获中国人民解放军总院军医进修学院肾脏病学博士学位，2013年于美国纽约西奈山医学中心任访问学者。1997年至今一直在大连理工大学附属大连市中心医院工作，于2012年取得主任医师职称，2014年起任肾内一科主任，2017年起任肾内学科主任。入选“辽宁省百千万人才”千人层次，享“大连市政府特殊津贴”。担任中国医师协会肾脏内科医师分会全国委员、中国中西医结合学会肾脏疾病专业委员会全国委员、中国女医师协会肾脏病及血液净化专家委员会全国委员、辽宁省医师协会肾病学医师分会副会长、大连市医学会肾脏病学专科分会主任委员。任《中华肾病研究电子杂志》、《中国医师进修杂志》、《JASN中文版》编委。

  长期从事肾脏病专业的临床和基础研究工作，主要研究方向为尿毒症毒素致病机制和精准清除，慢性肾脏病心脑血管并发症多组学整合研究。先后主持辽宁省自然科学基金项目2项，大连市科技局基金项目3项，大连市卫健委西医基金项目2项，大连市“登峰计划”自主立项项目4项。发表国内外核心学术期刊论文100余篇，其中SCI收录20篇，出版学术专著3部。获得辽宁省医学科技奖1项、辽宁省自然科学学术成果奖1项，大连市科技进步奖5项。

主持科研项目

(1) 2016年辽宁省自然科学基金项目,201602219,利用代谢组学技术评估尿毒症血液透析充分性的研究

(2) 2013年辽宁省自然科学基金项目,2013020224,帕立骨化醇改善5/6肾切除大鼠心肌病变及其机制研究

(3) 2019年大连市科技创新基金计划项目,2019J13SN115,透析液中加入聚环糊精对蛋白结合类尿毒症毒素的清除作用及机制研究

(4) 2014年大连市科技局计划项目,2014E14SF151,维持性血液透析患者左室舒张功能与心血管疾病预后关系的前瞻性队列研究

(5) 2008年大连市科委优秀技术青年基金项目,2008J23JH034,S期激酶相关蛋白2参与系膜细胞增殖调控的研究

(6) 2019年大连市医学科学研究计划项目,1911018,不同血液透析方式对大鼠体内硫酸吲哚酚清除影响的研究

(7) 2013年大连市医学科学研究计划项目,1311008,IgA肾病患者异常糖基化IgA1和氧化应激水平检测的意义

(8) 2021年大连市"登峰计划"自主立项项目,2021ZZ002,RBM4对链脲佐菌素诱导的糖尿病肾病小鼠的肾脏保护作用及机制研究

(9) 2021年大连市"登峰计划"自主立项项目,2021ZZ003,自体免疫细胞联合免疫检查点抑制剂治疗肾癌的临床前研究

(10) 2022年大连市"登峰计划"自主立项项目,2022ZZ231,慢性肾脏病细胞微环境调控和诱导血管钙化的机理探究

(11) 2022年大连市"登峰计划"自主立项项目,2022ZZ243,动静脉内瘘手术引起的血流动力学信号调控内皮损伤的体外模型及机制研究

主要论著

1) Shu‑Xin Liu*, Zhi‑HongWang, Shuang Zhang, Jia Xiao, Lian‑LianYou, Yu Zhang, Cui Dong, Xue‑NaWang, Zhen‑ZhenWang, Sheng‑NanWang, Jia‑Ni Song, Xiu‑Nan Zhao, Xin‑YiYan, Shu‑FanYu, Yi‑Nan Zhang. The association between dose of hemodialysis and patients mortality in a prospective cohort study. Scientific Reports, 2022, 12(1): 13708.

2) Shuang Zhang, Qi‑Jun Wu, Shu‑Xin Liu*. A methodologic survey on use of the GRADE approach in evidence syntheses published in high-impact factor urology and nephrology journals. BMC Medical Research Methodology, 2022, 22(1): 220.

3) Yuling Chen, Xiaohong Li, Lei Shi, Pengfei Ma, Wei Wang, Nan Wu, Youlin Gan, Xu Han, Shanshan Huang, Xiaohui Kang, Shuxin Liu*, Yuhong Zhen*. Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of adriamycinby reserving P-gp-mediated drug resistance in breast cancer. AGING, 2022, Vol. 14, Advance.

4) Baoshan Ma*, Bingjie Chai, Heng Dong, Jishuang Qi, Pengcheng Wang, Tong Xiong, Yi Gong, Di Li, Shuxin Liu*, Fengju Song*. Diagnostic classification of cancers using DNA methylation of paracancerous tissues. Scientific Reports, 12(1): 10646. 

5) Baoshan Ma*, Jishuang Qi, Yiming Wu, Pengcheng Wang, Di Li, Shuxin Liu*. Parameter estimation of the COVID-19 transmission model using an improved quantum-behaved particle swarm optimization algorithm. Digital Signal Processing, 2022,127: 103577.

6) Qian Li, Shuang Zhang, Qi-Jun Wu, Jia Xiao, Zhi-Hong Wang, Xiang-Wei Mu, Yu Zhang, Xue-Na Wang, Lian-Lian You, Sheng-Nan Wang, Jia-Ni Song, Xiu-Nan Zhao, Zhen-Zhen Wang, Xin-Yi Yan, Yu-Xin Jin, Bo-Wen Jiang, Shu-Xin Liu*. Serum total indoxyl sulfate levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: A prospective cohort study. BMC Nephrology, 2022, 23(1): 231.

7) Shuxin Liu*, Qijun Wu, Shuang Zhang, Zhihong Wang, Hong Liu, Lanbo Teng, Ping Xiao, Yan Lu, Xuena Wang, Cui Dong, Jia Xiao and Jiayu Zhang. Serum Galectin-3 levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study. BMC Nephrology. 2022, 23(1): 5.

8) Shuxin Liu*, Lingyun Jia*, Jia Xiao, Jingyu Li, Fangfang Mei, Jianan Zhou, Lulu Han, Lin Li, Jing Shan. Increased clearance of indoxyl sulphate in renal failure rats with the addition of water-soluble poly-β-cyclodextrin to the dialysate. Nephrology (Carlton). 2022, 27(4):376-382.

9) Shuxin Liu*, Hong Liu, Zhihong Wang, Lanbo Teng, Cui Dong, Tingting Gui, Yu Zhang. Effect of changing treatment to high-flux hemodialysis (HFHD) on mortality in patients with long-term low flux hemodialysis (LFHD): a propensity score matched cohort study. BMC Nephrology. 2020, 21(1): 485.

10) Jingyu Li, Lulu Han, Jian Xie, Shuxin Liu, Lingyun Jia. Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis. Carbohydr Polym, 2020, 247: 116665.

11) Quan Hong, Shuqiang Wang, Shuxin Liu, Xiangmei Chen, Guangyan Cai. LRG1 may accelerate the progression of ccRCC via the TGF-β pathway. Biomed Research International. 2020: 1285068.

12) Jilin Chen, Ying Liu, Xiangmei Chen, Xuefeng Sun, Wei Li, Wang Yang, Ping Li, Ximing Sun, Degang Wang, Hongli Jiang, Wei Shi, Wenhu Liu, Ping Fu, Xiaoqiang Ding, Ming Chang, Shuxin Liu, Xiao Yang, Ning Cao, Menghua Chen, Zhaohui Ni, Jing Chen, Shiren Sun, Xinling Liang, Huimin Wang, Yani He, Bihu Gao, Jianqin Wang, Lirong Hao, Jian Liu, Suhua Li, Qiang He, Hongmei Liu, Na Yi, Fengmin Shao, Jundong Jiao, Yuhuan Ma, Li Yao, Yi Sun, Detian Li, Lynda Szczech, Ming Fang, Zach Odeh, Hongli Lin. Assessment of dialysis initiation by a fuzzy mathematics equation (ADIFE): a study protocol for a randomised controlled trial. BMJ Open, 2019, 9(9): e023162.

13) Jingyu Li, Lulu Han, Shuxin Liu, Sai He, Yaming Cao, Jian Xie, Lingyun Jia. Removal of indoxyl sulfate by water-soluble poly-cyclodextrins in dialysis. Colloids and Surfaces B: Biointerfaces. 2018, 164: 406-413.

14) Shuxin Liu, Lichao Wang, Chunxiu Hu, Xin Huang, Hong Liu, Qiuhui Xuan, Xiaohui Lin, Xiaojun Peng, Xin Lu, Ming Chang*, Guowang Xu*. Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry. Scientific Reports. 2017, 7(1): 8150.

15) Lichao Wang, Chunxiu Hu, Shuxin Liu, Ming Chang, Peng Gao, Lili Wang, Zaifa Pan, and Guowang Xu. Plasma lipidomics investigation of hemodialysis effects by using liquid chromatography-mass spectrometry. Journal of Proteome Research. 2016, 15(6): 1986-1994.

16) Lanbo Teng, Ming Chang, Shuxin Liu, Min Niu, Yungang Zhang, Xiangfei Liu, Xiaoxia Yu. Peritoneal microvascular endothelial function and the microinflammatory state are associated with baseline peritoneal transport characteristics in uremic patients. International Urology and Nephrology. 2015, 47(1): 191–199.

17) Jian-jun Gao, Guang-yan Cai, Shu-wen Liu, Li Tang, Xue-guang Zhang, Yang Yang, Pu Chen, Shu-xin Liu, Jia-yao Ji, Suo-zhu Shi, Zhong Yin, Xiang-mei Chen. Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis. Rheumatology International. 2012, 32(6): 1751-1759.

18) Yang Lu, Shuxin Liu, Shujia Zhang, Guangyan Cai, Hongwei Jiang, Huabin Su, Xiaofan Li, Quan Hong, Xueguang  Zhang, Xiangmei Chen*. Tissue inhibitor of metalloproteinase-1 promotes NIH3T3 fibroblast proliferation by activating p-Akt and cell cycle progression. Molecules and Cells. 2011, 31(3): 225-30.

19) Yuansheng Xie, Songmin Huang, Li Wang, Lining Miao, Aiping Zhang, Ying Li,  Xiongfei Wu, Lining Wang, Shuxin Liu, Caihua  Lie, Pu Chen, Xiangmei Chen. Efficacy and safety of mizoribine combined with losartan in the treatment of IgA nephropathy: a multicenter, randomized, controlled study. American Journal of the Medical Sciences. 2011, 341(5): 367-372.

20) Shuxin Liu, Yuansheng Xie, Yang Lv, Fufang Qin, Bo Fu, Suozhu Shi, Zhong Yin, Quan Hong, Xueguang Zhang, Jianzhong Wang, Ming Chang, Xiangmei Chen*. A novel target of mizoribine inhibiting mesangial cell proliferation: s phase kinase-associated protein 2. American Journal of Nephrology. 2010, 32: 447-455.

著作成果

(1)《血液净化标准操作流程》编者，2021年，人民卫生出版社

(2)《透析饮食宝典》副主编，2019年，科学出版社

(3)《重症血液净化》编者，2017年，人民卫生出版社

科研及学术奖励

(1) 2019年辽宁省医学科技奖三等奖(排名1)：高通量透析改善尿毒症患者的预后及相关机制

(2) 2019年辽宁省自然科学学术成果奖二等奖(排名1)：Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography-Mass Spectrometry

(3) 2016年大连市科技进步二等奖(排名3)：尿毒症患者内皮细胞功能对基线腹膜转运特征性影响的研究

(4) 2011年大连市科技进步三等奖(排名1)：S期激酶相关蛋白2参与系膜细胞增殖的调控

(5) 2006年大连市科技进步三等奖(排名3)：慢性肾衰病人血管钙化相关因素的研究

(6) 2004年大连市科技进步三等奖(排名3)：高糖对系膜细胞诱生型一氧化氮合成酶表达及细胞外基质合成的影响  

(7) 2003年大连市科技进步三等奖(排名3)：一氧化氮与系膜细胞及细胞外基质相关因素的研究