Profile

李学召 副研究员 博导、硕导

2020年6月加入化学学院张大煜分子科学研究中心。主持国家自然科学基金面上项目（2021年）、青年项目（2017年）、第63批中国博士后科学基金面上项目（一等）、辽宁省博士启动基金项目；参与两项国家自然科学基金国际（地区）合作与交流项目。入选大连市青年才俊、引进城市发展紧缺人才（五星）、大连理工大学“星海骨干”计划支持。在Coord. Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Mater.等国际知名期刊发表学术论文多篇，部分文章入选杂志封面或背封面。

     手性Ir(III)基超分子组装与疾病光疗

研究方向

• 手性光活性功能Ir(III)金属-有机超分子螺旋结构组装-仿生识别分离与不对称光催化

• 手性Ir(III)超分子组装体与生物大分子特异性识别机制、生物学效应探究与疾病诊疗

欢迎具有配位化学，超分子化学，特别是化学生物学学术背景，对课题组研究方向感兴趣博后、博硕研究生，本科生加入！

论文发表

2023年

(14)  Xuezhao Li,*  Xing Zhao, Wen Wang, Zhuolin Shi, Yangming Zhang, Qingqing Tian, Yougang Yao, Cheng He, Chunying Duan,* Biomedical applications of multinuclear Pt(II)/Ru(II)/Ir(III) metallo-supramolecular assemblies for intensive cancer therapy, Coord. Chem. Rev., 2023, 495, 215366.

(13)  Xuezhao Li,* Zhicheng Wang, Xiaorou Hao, Jingyi Zhang, Xing Zhao, Yougang Yao, Wei Wei, Rui Cai, Cheng He, Chunying Duan,* Zijian Guo, Jing  Zhao,* and Xiuxiu Wang*, Optically Pure Double-Stranded Dinuclear Ir(III) Metallohelices Enabled Chirality-Induced Photodynamic Responses, J. Am. Chem. Soc., 2023, 145, 14766-14775.

(12) Guangli He, Maomao He, Ran Wang, Xuezhao Li,* Hanze Hu, Dongsheng Wang, Ziqian Wang, Yang Lu, Ning Xu, Jianjun Du, Jiangli Fan, Xiaojun Peng, Wen Sun*, A Near-Infrared Light-Activated Photocage Based on a Ruthenium Complex for Cancer Phototherapy, Angew. Chem. Int. Ed., 2023, 62, e202218768.

2022年

(11) Jinguo Wu, Xuezhao Li,* Zhuolin Shi, Cheng He*, Single-Crystal-to-Single-Crystal Transformation and Alcohols Enantioseparation of Homochiral Ir(III)-Metallohelix-Based Porous Molecular Crystal, Eur. J. Inorg. Chem., 2022, 27, e202200351. 

(10) Jinguo Wu, Xuezhao Li,* Pengyan Wu, Zhuolin Shi, Liyong Chen, Rong Zhang, Cheng He,* and Chunying Duan*, Engineering Homochiral Dinuclear-Ir(III)-Metallohelices-based Porous Molecular Crystals for Atropisomers Enantioseparation, Chem. Mater., 2022, 10, 4471-4478.

2021年

(9) Yuchao Li, Xuezhao Li,* Lili Li, Bing Xiao, Jinguo Wu, Hechuan Li, Danyang Li, Cheng He*, Phenoxazine-based supramolecular tetrahedron as biomimetic lectin for glucosamine recognition, Chin. Chem. Lett., 2021, 32, 735-739.

2020年

(8) Shuhua Cao, Xuezhao Li,* Yong Gao, Fahui Li, Kaoxue Li, Xuanxuan Cao, Yiwen Dai, Lirong Mao, Shanshan Wang and Xishi Tai*, A simultaneously GSH-depleted bimetallic Cu(II) complex for enhanced chemodynamic cancer therapy, Dalton Trans., 2020, 49, 11851-11858. 

(7) Xuezhao Li, Zhuolin Shi, Jinguo Wu, Jinlong Wu, Cheng He,* Xiaorou Hao and Chunying Duan,* Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy, Chem. Commun., 2020, 56, 7537-7548. 

(6) Xuezhao Li,^# Jinguo Wu,^# Lei Wang, Cheng He,* Liyong Chen, Yang Jiao, and Chunying Duan,* Mitochondrial-DNA-targeted Ir^III-Containing Metallohelices with Tunable Photodynamic Therapy Efficacy in Cancer Cells, Angew. Chem. Int. Ed., 2020, 59, 6420-6427.

(5) Tianchi Feng, Xuezhao Li,* Jinguo Wu, Cheng He, Chunying Duan, Cavity-directed nitroaromatics sensing within a carbazole-based luminescent supramolecular M₂L₃ cage, Chin. Chem. Lett., 2020, 31, 95-98.

Before 2020年

(4) Xuezhao Li, Jinguo Wu, Cheng He, Qingtao Meng, Chunying Duan,* Asymmetric Catalysis within the Chiral Confined Space of Metal-Organic Architectures, Small, 2019, 15, 1804770. 

(3) Hailing Wang, Lili Li, Xuezhao Li,* Cheng He, Encapsulation of organic dyes within an Electron-deficient redox metal−organic tetrahedron for photocatalytic proton reduction, Isr. J. Chem., 2019, 59, 273-279.

(2) Xuezhao Li, Jinguo Wu, Liyong Chen, Xiaoming Zhong, Cheng He,* Rong Zhang, Chunying Duan, Engineering an iridium-containing metal–organic molecular capsule for induced-fit geometrical conversion and dual catalysis, Chem. Commun., 2016, 52, 9628-9631. 

(1) Xuezhao Li, Jinguo Wu, Cheng He,* Rong Zhang, Chunying Duan, Multicomponent self-assembly of a pentanuclear Ir-Zn heterometal-organic polyhedron for carbon dioxide fixation and sulfite sequestration, Chem. Commun., 2016, 52, 5104-5107.

学术报告

5. 2023, 6.17-6.20 

邀请报告，中国化学会第33届学术年会，生物无机化学分会。中国，青岛

李学召  双核Ir(III)螺旋结构手性调控----生物大分子特异性识别与光动力治疗

4. 2022, 6.17-6.20

口头报告，第9届全国配位化学会议。中国，郑州

李学召  DNA靶向（手性）双核Ir(III)螺旋结构光动力治疗

3. 2021, 4.19-4.22

口头报告，中国化学会第32届学术年会，生物无机化学分会。中国，珠海

李学召  “结构本征”靶向DNA双核Ir(III)螺旋体光动力癌症治疗

2.  2018, 7.29-8.04

邀请报告，第43届国际配位化学会议，S43 Chiral Functional Materials 分会。日本，仙台

李学召  “Chiral Self-Sorting during Helicates Formation Based on Stereochemically 'pre-programmed' Ir(III) Modules”

1. 2017, 10.19-10.22 

口头报告，第8届全国配位化学会议。中国，大连

李学召  “Heterometallic Ir(III) Complexes Containing MOP: Construction and Properties”