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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn 13898422633
电子邮箱：mengqw@dlut.edu.cn
Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
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论文类型：期刊论文
发表时间：2006-09-01
发表刊物：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
收录刊物：SCIE、PubMed、Scopus
卷号：41
期号：9
页面范围：1084-1089
ISSN号：0223-5234
关键字：severe acute respiratory syndrome; coronavirus; stilbene derivatives
摘要：Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (<= 0.5 mg ml(-1)) and no significant cytotoxic effects were observed in vitro. (c) 2006 Elsevier SAS. All rights reserved.