孙冰冰

基本信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:美国华盛顿大学

学位:博士

在职信息:在职

所在单位:化工学院

学科:化学工程

办公地点:西部校区化学工程实验楼D211

联系方式:+86-411-84986513

电子邮箱:

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个人简介Personal Profile

孙冰冰,教授,博士生导师。2002、2005年于大连理工大学获得学士、硕士学位,2011年于美国华盛顿大学化学工程系获得博士学位,2011-2016年在美国加州大学洛杉矶分校医学院及加州大学纳米技术环境影响中心从事博士后研究工作。致力于生物材料、纳米材料-生物界面、免疫工程、疫苗佐剂、纳米材料生物安全性、以及环境污染物的评价与预防等研究。多学科交叉型的研究涉及了生物学、化学、材料学、医学及环境学等领域。

实验室长期招收博士后,请发简历到bingbingsun@dlut.edu.cn。


Publication List:

43. Mirshafiee, V*.; Sun, B.*; Chang, C.H.; Jiang, W.; Jiang, J.; Liu, X.; Liao Y.-P.; Wang, X.; Nel, A.E.; Xia, T. “Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes”. ACS Nano, 2018, 12 (4), 3836-3852. *Equal contribution.

42. Li, R.; Guiney, L.; Chang, C.H.; Mansukhani, N.; Ji, Z.; Wang, X.; Liao Y.-P.; Jiang, W.; Sun, B.; Hersam, M.; Nel, A.; Xia, T. “The Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model”. ACS Nano, 2018, 12 (2), 1390-1402.

41. Lu, J.; Liu, X.; Liao Y.-P.; Bergara, F.; Sun, B.; Jiang, W.; Chang, C.H., Jiang, J.; Wang, X.; Wu, A.; Meng, H.; Nel, A.E. “Nano-enabled Pancreas Cancer Immunotherapy using Immunogenic Cell Death and Reversing Immunosuppression”. Nature Communications, 2017, DOI: 10.1038/s41467-017-01651-9.

40. Sun, B.*; Ji, Z.; Liao, Y.-P.; Chang, C.H.; Justine, K.; Wang, X.; Mirshafiee, V.; Xue, C.; Xia, T*. “Enhanced immune adjuvant activity of aluminum oxyhydroxide nanorods through cationic surface functionalization”. ACS Applied Materials & Interfaces, 2017, 9 (26), 21697-21705. *Corresponding author. 

39. Mirshafiee, V.; Jiang, W.; Sun, B.; Wang, X.; Xia, T. “Facilitating translational nanomedicine via predictive safety assessment”. Molecular Therapy, 2017, 25 (7), 1522-1530. 

38. Wang, X.*; Sun, B.*; Liu, S.; Xia, T. “Structure activity relationships of engineered nanomaterials in inducing NLRP3 inflammasome activation and chronic lung fibrosis”. NanoImpact, 2017, 6, 99-108. *Equal contribution. 

37. Jiang, W.; Wang, X.; Du, Y.; Chang, C.H.; Liao, Y-P.; Osberne, O.; Sun, B.; Jiang, J.; Ji, Z.; Li, R.; Liu, X.; Lu, J.; Lin, S.; Meng, H.; Xia, T.; Nel, A.E. “Pro-inflammatory and pro-fibrogenic effects of ionic and particulate arsenide and indium-containing semiconductor materials in the murine lung”. ACS Nano, 2017, 11 (2), 1869-1883. 

36. Chen, Y.; Wu, Y.; Sun, B.; Liu, S; Liu, H. “Two-dimensional nanomaterials for cancer nanotheranostics”. Small, 2017, 13 (10), 1603446. 

35. Sun, B.; Wang, X.; Liao, Y.-P.; Ji, Z.;  Chang, C.H.; Pokhrel, S.; Justine, K.; Liu, X.; Wang, M.; Dunphy, D.; Li, R.; Meng, H.; Mädler, L.; Brinker, C.J.; Nel, A.E.; Xia, T. “Repetitive dosing of fumed silica leads to profibrogenic effects through unique structure-activity relationships and biopersistence in the lung”. ACS Nano, 2016, 10 (8), 8054-8066. 

34. Sun, B.*; Xia, T. “Nanomaterial-based vaccine adjuvants”. Journal of Materials Chemistry B, 2016, 4, 5496-5509. *Corresponding author. 

33. Ji, E.H.*; Sun, B.*; Zhao, T.; Shu, S.; Chang, C.H.; Messadi, D.; Xia, T.; Zhu, Y.; Hu, S. “Characterization of electronic cigarette aerosol and its induction of oxidative stress response in oral keratinocytes”. PLOS ONE, 2016, 11(5): e0154447. *Equal contribution. Highlighted by UCLA Newroom, Mynewsla, abc7, MedlinePlus (NIH), Medicalnewstoday, Medicalxpress, etc. 

32. Wang, X.; Mansukhani, N.; Guiney, L.; Lee, J.-H.; Li, R.; Sun, B.; Liao, Y.-P.; Chang, C.H.; Ji, Z.; Xia, T.; Hersam, M.C.; Nel, A.E. “Toxicological profiling of highly-purified metallic and semiconducting single-walled carbon nanotubes in the rodent lung and E. coli”. ACS Nano, 2016, 10 (6), 6008–6019. 

31. Liu, J.; Sun, B.; Yin, H.; Liu, S. “Hepcidin: a promising therapeutic target for iron disorders”. Medicine, 2016, 95(14), e3150. 

30. Sun, B.; Taing, A.; Liu, H.; Nie, G.; Wang, J.; Fang, Y.; Liu, L.; Xue Y., Liao, Y.-P.; Ku, J.; Xia, T.; Liu, Y. “Nerve growth factor-conjugated mesoporous silica nanoparticles promote neuron-like PC12 cell proliferation and neurite growth”. Journal of Nanoscience and Nanotechnology, 2016, 16 (3), 2390-2393. 

29. Sun, B.; Shen, H. “Controlling surface-induced nanocomposites by lipoplexes for enhanced gene transfer”. Journal of Nanomaterials, 2015, 784836. 

28. Jiang, W.; Lin, S.; Chang, C.H.; Ji, Z.; Sun, B.; Wang, X.; Li, R.; Pon, N.; Xia, T.; Nel, A.E. “Implications of the differential toxicological effects of III-V ionic and particulate materials for hazard assessment of semiconductor slurries”. ACS Nano, 2015, 9 (12), 12011-12025. 

27. Sun, B.; Pokhrel, S.; Dunphy, D.; Zhang, H.; Ji, Z.; Wang, X.; Wang, M.; Liao, Y.-P.; Chang, C.H.; Dong, J.; Li, R.; Mädler, L.; Brinker, C.J.; Nel, A.E.; Xia, T. “Reduction of acute inflammatory effects of fumed silica nanoparticles in the lung by adjusting silanol display through calcination and metal doping”. ACS Nano, 2015, 9 (9), 9357-9372. Highlighted by ACS Nanotation. 

26. Wang, X.; Mansukhani, N.; Guiney, L.; Ji, Z.; Chang, C.H.; Wang, M.; Liao, Y.-P.; Song, T.-B., Sun, B.; Li, R.; Xia, T.; Hersam, M.C.; Nel, A.E. “Differences in the toxicological potential of two-dimensional versus aggregated molybdenum disulfide in the lung”. Small, 2015, 11 (38), 5079-5087. 

25. Sun, B.; Shen, H. “Correlation of the composition of biominerals with their ability of stimulating intracellular DNA sensors and inflammatory cytokines”. Biomaterials, 2015, 54, 106-115. Highlighted by Nanowerk. 

24. Li, R.; Ji, Z.; Dong, J.; Chang, C.H.; Wang, X.; Sun, B.; Wang, M.; Liao, Y.-P.; Zink, J.; Nel, A.E.; Xia, T. “Enhancing the imaging and biosafety of upconversion nanoparticles through phosphonate coating”. ACS Nano, 2015, 9 (3), 3293–3306. 

23. Tang, Q.; Lei, X.; Cao, B.; Sun, B.; Zhang, Y.; Cheng, G. “A naturally derived dextran-peptide vector for microRNA antagomir delivery”. RSC Advances, 2015, 5, 28019-28022. 

22. Wang, X.; Duch, M.; Mansukhani, N.; Ji, Z; Liao, Y.-P.; Wang, M.; Zhang, H.; Sun, B.; Chang, C.H.; Li, R; Lin, S.; Meng, H.; Xia, T.; Hersam, M.C.; Nel, A.E. “Use of a predictive toxicological approach that utilizes the pro-fibrogenic effects of carbon nanotubes and graphene for tiered decision analysis of testing requirements for carbon-based nanomaterials”. ACS Nano, 2015, 9 (3), 3032–3043. 

21. Sun, B.; Wang, X.; Ji, Z.; Wang, M.; Liao, Y.-P.; Chang, C.H.; Li, R.; Zhang, H.; Nel, A.E.; Xia, T. “NADPH oxidase dependent NLRP3 inflammasome activation plays an important role in lung fibrosis by multi-walled carbon nanotubes”. Small, 2015, 11 (17), 2087-2097. Highlighted by MaterialsViewsChina. 

20. Li, R.; Ji, Z.; Qin, H.; Kang, X.; Sun, B.; Wang, M.; Chang, C.H.; Wang, X.; Zhang, H.; Zou, H.; Nel, A.E.; Xia, T. “Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome”. ACS Nano, 2014, 8 (10), 10280-10292. 

19. Tang, Q.; Cao, B.; Lei, X.; Sun, B.; Zhang, Y.; Cheng, G. “Dextran-peptide hybrid for efficient gene delivery”. Langmuir, 2014, 30 (18), 5202-5208. 

18. Zhang, H.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C.H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Liao, Y.-P.; Liu, R.; Xia, T.; Mädler, L.; Nel, A.E. “PdO doping tunes band-gap energy levels as well as oxidative stress responses to a Co3O4 p-type semiconductor in cells and the lung”. Journal of the American Chemical Society, 2014, 136 (17), 6406-6420. 

17. Li, R.; Ji, Z.; Chang, C.H.; Dunphy, D.; Cai, X.; Meng, H.; Zhang, H.; Sun, B.; Wang, X.; Dong, J.; Lin, S.; Wang, M.; Liao, Y.-P.; Brinker, C.J.; Nel, A.E.; Xia, T. “Surface interactions with compartmentalized cellular phosphates explains rare earth oxide nanoparticle hazard and provides opportunities for safer design”. ACS Nano, 2014, 8 (2), 1771-1783. 

16. Cao, B.; Li, L.; Wu, H.; Tang, Q.; Sun, B.; Dong, H.; Zhe, J.; Cheng, G. “Zwitteration of dextran: a facile route to integrate antifouling, switchability and optical transparency into natural polymers”. Chemical Communications, 2014, 50, 3234-3237. 

15. Wang, X.; Ji, Z.; Chang, C.H.; Zhang, H.; Lin, S.; Meng, H.; Wang, M.; Liao, Y.-P.; Li, R.; Sun, B.; Van Winkle, L.S.; Pinkerton, K.; Zink, J.; Xia, T.; Nel, A.E. “Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential”. Small, 2014, 10 (2), 385-398. 14. Sun, B.; Ji, Z.; Liao, Y.-P.; Wang, M.; Wang, X.; Dong, J.; Chang, C.H.; Li, R.; Nel, A.E.; Xia, T. “Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles”. ACS Nano, 2013, 7 (12), 10834-10849. Highlighted as Key Scientific Article by Global Medical Discovery. 

13. Sun, B.; Wang, X.; Li, R.; Ji, Z.; Xia, T. “NLRP3 inflammasome activation induced by engineered nanomaterials”. Small, 2013, 9 (9-10), 1595-1607. 

12. Sun, B.; Li, R.; Wang, X.; Xia, T. “Predictive toxicological paradigm and high throughput approach for toxicity screening of engineered nanomaterials”. International Journal of Biomedical Nanoscience and Nanotechnology, 2013, 3 (1-2), 4-18. 

11. Qu G.; Liu, S.; Zhang, S.; Wang, L.; Wang, X.; Sun, B.; Yin, N.; Gao, X.; Xia, T.; Chen, J.; Jiang, G. “Graphene oxide induces Toll-like receptor 4 (TLR4)-dependent necrosis in macrophages”. ACS Nano, 2013, 7 (7), 5732 - 5745. 

10. Li, R.; Wang, X.; Ji, Z.; Sun, B.; Zhang, H.; Chang, C.H.; Lin, S.; Meng, H.; Liao, Y.-P.; Wang, M.; Li, Z.; Hwang, A.A.; Song, T.-B.; Xu, R.; Yang, Y.; Zink, J.; Nel, A.E.; Xia, T. “Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity”. ACS Nano, 2013, 7 (3), 2352-2368. 

9. Zhang, H.; Dunphy, D.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z.; Li, R.; Garcia, F.; Yang, J.; Kirk, M.; Xia, T.; Zink, J.; Nel, A.E.; Brinker, C.J. “Processing pathway dependence of amorphous silica nanoparticle toxicity - colloidal versus pyrolytic”. Journal of the American Chemical Society, 2012, 134 (38), 15790-15804. 

8. Ji, Z.; Wang, X.; Zhang H.; Lin, S.; Meng, H.; Sun, B.; George, S.; Xia, T.; Nel, A.E.; Zink, J. “Designed synthesis of CeO2 nanorods and nanowires for studying toxicological effects of high aspect ratio materials”. ACS Nano, 2012, 6 (6), 5366-5380. 

7. Wang, X.; Xia, T.; Duch, M.; Ji, Z.; Zhang, H.; Li, R.; Sun, B.; Lin, S.; Meng, H.; Liao, Y.-P.; Wang, M.; Song, Z.-B.; Yang, Y.; Hersam, M.C.; Nel, A.E. “Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury”. Nano Letters, 2012, 12 (6), 3050-3061. 

6. Sun, B.; Yi, M.; Yacoob, C.; Nguyen, H.; Shen, H. “Effect of surface chemistry on gene transfer efficiency mediated by surface-induced DNA-doped nanocomposites”. Acta Biomaterialia, 2012, 8 (3), 1109-1116. 

5. Nguyen, H.; Tran, K.K.; Sun, B.; Shen, H. “Activation of inflammasomes by tumor cell death mediated by gold nanoshells”. Biomaterials, 2012, 33 (7), 2197-2205. 

4. Chen, H.; Sun, B.; Tran, K.K.; Shen, H. “Effects of particle size on toll-like receptor 9-mediated cytokine profiles”. Biomaterials, 2011, 32 (6), 1731-1737. 

3. Sun, B.; Tran, K.K.; Shen, H. “Enabling customization of non-viral gene delivery systems for individual cell types by surface-induced mineralization”. Biomaterials, 2009, 30 (31), 6386-6393. 

2. Chen, H.-H.; Sun, B.; Tran, K.K.; Shen, H.; Gao, D. “A microfluidic manipulator for enrichment and alignment of moving cells and particles”. Journal of Biomechanical Engineering, 2009, 131 (7), 074505. 

1. Ma, X.; Sun, B.; Liu, T.; Cui, Z. “Study of microscopic experiment for freezing/vitrifying characteristics of CPA solution and cell suspension”. Journal of Dalian University of Technology, 2005, 45 (4), 517-521.


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